Effect of fructose or sucrose feeding with different levels on oral glucose tolerance test in normal and type 2 diabetic rats
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg or 0.4 g/kg body weight) might affect oral glucose tolerance test (OGTT) in normal and type 2 diabetic rats. In OGTT, there were no significant differences in glucose responses between acute fructose- and sucrose-administered groups. However, in normal rats, the AUCs of the blood glucose response for the fructose-administered groups tended to be lower than those of the control and sucrose-administered groups. The AUCs of the lower levels fructoseor sucrose-administered groups tended to be smaller than those of higher levels fructose- or sucrose-administered groups. In type 2 diabetic rats, only the AUC of the lowest level of fructose-administered (0.05 g/kg body weight) group was slightly smaller than that of the control group. The AUCs of fructose-administered groups tended to be smaller than those of the sucrose-administered groups, and the AUCs of lower levels fructose-administered groups tended to be smaller than those fed higher levels of fructose. We concluded from this experiment that fructose has tendency to be more effective in blood glucose regulation than sucrose, and moreover, that smaller amount of fructose is preferred to larger amount. Specifically, our experiments indicated that the fructose level of 0.05 g/kg body weight as dietary supplement was the most effective amount for blood glucose regulation from the pool of 0.05 g/kg, 0.1 g/kg and 0.4 g/kg body weights. Therefore, our results suggest the use of fructose as the substitute sweetener for sucrose, which may be beneficial for blood glucose regulation.
Abstract
This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg or 0.4 g/kg body weight) might affect oral glucose tolerance test (OGTT) in normal and type 2 diabetic rats. In OGTT, there were no significant differences in glucose responses between acute fructose- and sucrose-administered groups. However, in normal rats, the AUCs of the blood glucose response for the fructose-administered groups tended to be lower than those of the control and sucrose-administered groups. The AUCs of the lower levels fructoseor sucrose-administered groups tended to be smaller than those of higher levels fructose- or sucrose-administered groups. In type 2 diabetic rats, only the AUC of the lowest level of fructose-administered (0.05 g/kg body weight) group was slightly smaller than that of the control group. The AUCs of fructose-administered groups tended to be smaller than those of the sucrose-administered groups, and the AUCs of lower levels fructose-administered groups tended to be smaller than those fed higher levels of fructose. We concluded from this experiment that fructose has tendency to be more effective in blood glucose regulation than sucrose, and moreover, that smaller amount of fructose is preferred to larger amount. Specifically, our experiments indicated that the fructose level of 0.05 g/kg body weight as dietary supplement was the most effective amount for blood glucose regulation from the pool of 0.05 g/kg, 0.1 g/kg and 0.4 g/kg body weights. Therefore, our results suggest the use of fructose as the substitute sweetener for sucrose, which may be beneficial for blood glucose regulation.
참고문헌 (60)
- Atkinson AM, "Acute administration of fructose, with glucose, causes a significant decrease in early plasma glucose levels in rodents", Diabetes, 49, pp.A278~ (2000), A 278.
- Bantle JP, "Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects", N Engl J Med, 309, pp.7~12 (1983)
- Bantle JP, "Metabolic effects of dietary fructose and sucrose in type I and II diabetic subjects", JAMA, 256, pp.3241~3246 (1986)
- Bantle JP, "Clinical aspects of sucrose and fructose metabolism", Diabetes Care, 12, pp.56~61 (1989)
- Basciano H, "Fructose, insulin resistance, and metabolic dyslipidemia", Nutr Metab, 2, pp.1~14 (2005)
- Bray GA, "Consumption of highfructose corn syrup in beverages may play a role in the epidemic of obesity", Am J Clin Nutr, 79, pp.537~543 (2004)
- Cannon MC, "The serum insulin and plasma glucose responses to milk and fruit products in type 2 (non-insulin-dependent) diabetic patients", Diabetologia, 29, pp.784~791 (1986)
- Centers for Disease Control and Prevention NCfHS,Division of Health Interview Statistics, "Census of the population and population estimates. Hyattsville, MD. Centers for Disease Control and Prevention", ~ (1997)
- Ciok J, "The role of glycemic index concept in carbohydrate metabolism", Przegl Lek, 63, pp.287~291 (2006)
- Corpe CP, "The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes", Pfluegers Arch, 432, pp.192~201 (1996)
- Crapo PA, "The metabolic effects of 2-week fructose feeding in normal subjects", Am J Clin Nutr, 39, pp.525~534 (1984)
- Curry DL, "Effect of mannose and fructose on the synthesis and secretion of insulin", Pancreas, 4, pp.2~4 (1989)
- Dietary reference intakes for Koreans, "Ministry of Health and Welfare", The Korean Nutrition Society, 0~409 (2005)
- Faeh D, "Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in normal men", Diabetes, 54, pp.1907~1913 (2005)
- Hasegawa K, "Baseline data comparing CD(SD)IGS rats supplied from Charles River Japan, Charles River UK and Charles River USA", CD(SD)IGS study group, 9~18 (2001)
- Henry RR, "Current issues in fructose metabolism", Annu Rev Nutr, 11, pp.21~39 (1991)
- Hwang IS, "Fructoseinduced insulin resistance and hypertension in rats", Hypertension, 10, pp.512~516 (1987)
- Jeckins DJA, "Glycemic index of foods, a physiological basis for carbohydrate exchange", Am J Clin Nutr, 34, pp.362~366 (1981)
- Jurgens H, "Consuming fructose-sweetened beverages increases body adiposity in mice", Obes Res, 13, pp.1146~1156 (2005)
- Kasim-Karakas SE, "Effects of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters", J Lab Clin Med, 128, pp.208~213 (1996)
- Kellett GL, "Apical GLUT2: a major pathway of intestinal sugar absorption", Diabetes, 54, pp.3056~3062 (2005)
- Kellett GL, "The diffusive component of intestinal glucose absorption is mediated by the glucose induced recruitment of GLUT2 to the brush-border membrane", Biochem J, 350, pp.155~162 (2000)
- Koivisto VA, "Fructose as a dietary sweetener in diabetes mellitus", Diabetes Care, 1, pp.241~246 (1978)
- "Food balance sheet" (2004)[URL]
- Koyama M, "Accelerated loss of islet β cells in sucrose-fed Goto- Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus", Am J Pathol, 153, pp.537~565 (1998)
- Kwon O, "Inhibition of the intestinal glucose transporter GLUT2 by flavonoids", FASEB J, 21, pp.366~377 (2007)
- Levi B, "Long-term fructose consumption accelerates glycation and several age-related variables in male rat", J Nutr, 128, pp.1442~1449 (1998)
- Ludwig DS, "Dietary fiber, weight gain, and cardiovascular risk factors in young adults", J Am Med Assoc, 282, pp.1539~1546 (1999)
- Mayer PA, "Intermediary metabolism of fructose", Am J Clin Nutr, 58, pp.754S~765S (1993)
- "Report on 1998 National Health and Nutrition Survey: Nutrition Survey"[URL]
- "Report on 2005 National Health and Nutrition Survey/Nutrition Survey." (2006)[URL]
- Mokdad AH, "The continuing epidemics of obesity and diabetes in the United States", JAMA, 286, pp.1195~1200 (2001)
- Mokdad AH, "Diabetes trends in the US: 1990-1998", Diabetes Care, 23, pp.1278~1283 (2000)
- Mokdad AH, "The spread of the obesity epidemic in the United States, 1991-1998", JAMA, 282, pp.1519~1522 (1999)
- Moore MC, "Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults", J Clin Endocrinol Metab, 85, pp.4515~4519 (2000)
- Moore MC, "Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes", Diabetes Care, 24, pp.1882~1887 (2001)
- Nutrition Subcommittee of the British Diabetic Association’s Professional Advisory Committee, "Sucrose and fructose in the diabetic diet", Diabet Med, 7, pp.764~769 (1990)
- Olefsky JM, "Fructose, xylitol and sorbitol", Diabetes Care, 3, pp.390~393 (1980)
- Ostenson C-G, "Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat. Lessons from Animal Diabetes", 299~315 (1996)
- Ostenson C-G, "Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat", Diabetologia, 36, pp.3~8 (1993)
- Pankowska E, "The evolution of insulin therapy and new insight into nutrition recommendations for individuals with diabetes", Przegl Lek, 63, pp.284~286 (2006)
- Pan XR, "Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group", Diabetes Care, 20, pp.1664~1669 (1997)
- Petersen KF, "Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans", Diabetes, 50, pp.1263~1268 (2001)
- Portha B, "ß-cell sensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes", Diabetes, 40, pp.486~491 (1991)
- Ramachandran A, "Rising prevalence of NIDDM in an urban population in India", Diabetologia, 40, pp.232~237 (1997)
- Salmeron J, "Dietary fiber, glycemic load, and risk of NIDDM in men", Diabetes Care, 20, pp.545~550 (1997)
- Salmeron J, "Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women", J Am Med Assoc, 277, pp.472~477 (1997)
- Salmeron J, "Dietary fiber, glycemic load, and risk of NIDDM in men", Diabetes Care, 20, pp.545~550 (1997)
- Sato Y, "Immunohistochemical localization of facilitateddiffusion glucose transporters in rat pancreatic islets", Tissue Cell, 28, pp.637~643 (1996)
- Schauberger G, "Diabetes", 26, pp.415~ (1977)
- Shiota M, "Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog", Diabetes, 51, pp.469~478 (2002)
- Swan DC, "Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma sugar, and plasma insulin during oral carbohydrate tolerance tests", Lancet, 1, pp.60~63 (1966)
- The Korean Nutrition Society, "The actual condition and management of obesity of people in Korea", Fall Conference of the Korean Nutrition Society (2006)
- The Korean Society of Food Science and Nutrition, "Handbook of experiments in food science and nutrition: Nutrition" (2000), Hyoil Press Co.
- Truswell AS, "Glycaemic index of foods", Eur J Clin Nutr, 46S, pp.91~101 (1992)
- Uusitupa MI, "Fructose in the diabetic diet", 59, pp.753S~757S (1994)
- Watson RT, "Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4", Exp Cell Res, 271, pp.75~83 (2001)
- Wolf BW, "Supplemental fructose attenuates postprandial glycemia in Zucker fatty fa", fa rats, 2002, pp.132, 121912~121923
- Wood IS, "Glucose transporters (GLUT and SGLUT): expanded families of sugar transport proteins", Br J Nutr, 89, pp.3~9 (2003)
- Zimmet P, "Global and societal implications of the diabetes epidemic", Nature, 414, pp.782~787 (2001)