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Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults

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Flavan-3-ols are a subclass of flavonoids found in a variety of foods including teas. The effects of flavan-3-ols on the risk of metabolic syndrome (MetS) have been investigated, generally focusing on tea catechins or individual flavan-3-ol rich foods, but there is little information on dietary flavan-3-ols intake and risk of MetS in population-based studies. In this cross-sectional study, we examined the association between dietary flavan-3-ols intake and the risk of MetS in Korean adults. Subjects comprised 1,827 men and 2,918 women aged 20-69 years whose data was included in the 2008 Korean National Health and Nutrition Examination Survey. This survey was conducted between January 2008 and December 2008. Total flavan-3-ols intakes were calculated from 24-hour dietary recalls using a flavonoids database. Thirty percent of the male subjects and 24% of the female subjects were reported as having MetS. In the female subjects, flavan3-ols intake was inversely associated with the risk of MetS after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.91, P for trend = 0.384). The main food source of flavan-3-ols was green tea followed by apples and grapes. Among MetS components, flavan3-ols intake was inversely associated with the risk of high blood pressure after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.90, P for trend = 0.005). No significant association between flavan-3-ols intake and risk of MetS was found in the male subjects. After stratified analysis by obesity (BMI ≥ 25 or BMI < 25), however, flavan3-ols intake was inversely related to the risk of hypertension in non-obese men. These results suggest that dietary flavan-3-ols intake may have beneficial effects on MetS risk by reducing the risk of hypertension. The effects of flavan-3-ols intake dependent on obesity need further investigation.

Abstract

Flavan-3-ols are a subclass of flavonoids found in a variety of foods including teas. The effects of flavan-3-ols on the risk of metabolic syndrome (MetS) have been investigated, generally focusing on tea catechins or individual flavan-3-ol rich foods, but there is little information on dietary flavan-3-ols intake and risk of MetS in population-based studies. In this cross-sectional study, we examined the association between dietary flavan-3-ols intake and the risk of MetS in Korean adults. Subjects comprised 1,827 men and 2,918 women aged 20-69 years whose data was included in the 2008 Korean National Health and Nutrition Examination Survey. This survey was conducted between January 2008 and December 2008. Total flavan-3-ols intakes were calculated from 24-hour dietary recalls using a flavonoids database. Thirty percent of the male subjects and 24% of the female subjects were reported as having MetS. In the female subjects, flavan3-ols intake was inversely associated with the risk of MetS after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.91, P for trend = 0.384). The main food source of flavan-3-ols was green tea followed by apples and grapes. Among MetS components, flavan3-ols intake was inversely associated with the risk of high blood pressure after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.90, P for trend = 0.005). No significant association between flavan-3-ols intake and risk of MetS was found in the male subjects. After stratified analysis by obesity (BMI ≥ 25 or BMI < 25), however, flavan3-ols intake was inversely related to the risk of hypertension in non-obese men. These results suggest that dietary flavan-3-ols intake may have beneficial effects on MetS risk by reducing the risk of hypertension. The effects of flavan-3-ols intake dependent on obesity need further investigation.

참고문헌 (37)

  1. Williamson G, "Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies", Am J Clin Nutr, 81, pp.243~255 (2005)
  2. Manach C, "Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies", Am J Clin Nutr, 81, pp.230~242 (2005)
  3. Yao LH, "Singanusong R, Chen SS. Flavonoids in food and their health benefits", Plant Foods Hum Nutr, 59, pp.113~122 (2004)
  4. Bonora E, "Metabolic syndrome: epidemiology and more extensive phenotypic description. Crosssectional data from the Bruneck Study", Int J Obes Relat Metab Disord, 27, pp.1283~1289 (2003)
  5. Wilson PW, "Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus", Circulation, 112, pp.3066~3072 (2005)
  6. Ford ES., "Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence", Diabetes Care, 28, pp.1769~1778 (2005)
  7. Sahyoun NR, "Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults", Am J Clin Nutr, 83, pp.124~131 (2006)
  8. Liu S, "Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women", Diabetes Care, 28, pp.2926~2932 (2005)
  9. Kim JA, "Dietary patterns and the metabolic syndrome in Korean adolescents - 2001 Korean National Health and Nutrition Survey", DIABETES CARE, 30, pp.1904~1905
  10. Kobayashi M, "Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterolfed rats", Biosci Biotechnol Biochem, 69, pp.2455~2458 (2005)
  11. Ikeda I, "Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats", J Nutr, 135, pp.155~159 (2005)
  12. Ikeda I, "Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats", Biosci Biotechnol Biochem, 69, pp.1049~1053 (2005)
  13. Imai K, "Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases", BMJ, 310, pp.693~696 (1995)
  14. Sano J, "Effects of green tea intake on the development of coronary artery disease", Circ J, 68, pp.665~670 (2004)
  15. Kuriyama S, "Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study", JAMA, 296, pp.1255~1265 (2006)
  16. Høstmark AT, "The Oslo Health Study: a Dietary Index estimating high intake of soft drinks and low intake of fruits and vegetables was positively associated with components of the metabolic syndrome", Appl Physiol Nutr Metab, 35, pp.816~825 (2010)
  17. Miura K, "Relation of vegetable, fruit, and meat intake to 7-year blood pressure change in middle-aged men: the Chicago Western Electric Study", Am J Epidemiol, 159, pp.572~580 (2004)
  18. Andrade AC, "Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects", Clinics (Sao Paulo), 64, pp.435~442 (2009)
  19. Grassi D, "Black tea consumption dose-dependently improves flowmediated dilation in healthy males", J Hypertens, 27, pp.774~781 (2009)
  20. Grundy SM, "Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute", American Heart Association conference on scientific issues related to definition, 2004, pp.109, 433~438
  21. Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", DIABETES RES CLIN PRACT, 75(1), pp.72~80 (2007), ELSEVIER IRELAND LTD
  22. "USDA Database for the Flavonoid Content of Selected Foods"[URL]
  23. "Functional Food Factor"[URL]
  24. National Academy of Agricultural Science, "Tables of Food Functional Composition", National Academy of Agricultural Science, ~ (2009)
  25. Johannot L, "Age-related variations in flavonoid intake and sources in the Australian population", Public Health Nutr, 9, pp.1045~1054 (2006)
  26. Zamora-Ros R, "Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain)", J Am Diet Assoc, 110, pp.390~398 (2010)
  27. Chun OK, "Estimated dietary flavonoid intake and major food sources of U.S. adults", J Nutr, 137, pp.1244~1252 (2007)
  28. Cho SH, "Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers", CIRCULATION JOURNAL, 70(8), pp.1052~1057 (2006), JAPANESE CIRCULATION SOC
  29. Tinahones FJ, "Green tea reduces LDL oxidability and improves vascular function", J Am Coll Nutr, 27, pp.209~213 (2008)
  30. Antonello M, "Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts", Am J Hypertens, 20, pp.1321~1328 (2007)
  31. Potenza MA, "EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I", R injury in SHR, 2007, pp.292, 1378~1387
  32. Miura Y, "Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice", J Nutr, 131, pp.27~32 (2001)
  33. Lorenz M, "A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation", J Biol Chem, 279, pp.6190~6195 (2004)
  34. Schewe T, "How do dietary flavanols improve vascular function? A position paper", Arch Biochem Biophys, 476, pp.102~106 (2008)
  35. Anderson RA, "Tea enhances insulin activity", J Agric Food Chem, 50, pp.7182~7186 (2002)
  36. Mizugaki M, "Epigallocatechin gallate increase the prostacyclin production of bovine aortic endothelial cells", Prostaglandins Other Lipid Mediat, 62, pp.157~164 (2000)
  37. Kalgaonkar S, "Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models", Phytother Res, 24, pp.1223~1228 (2010)

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