Hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus
2
조회
0
다운로드
9
인용
0
참고문헌
키워드
초록
BACKGROUND/OBJECTIVES: The primary objective of the treatment of diabetes mellitus is the attainment of glycemic control. Hyperglycemia increases oxidative stress which contributes to the progression of diabetic complications. Thus, the purpose of this study was to investigate the hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus. MATERIALS/METHODS: Rats with streptozotocin-induced diabetes received an oral administration of a starch solution (1 g/kg) either with or without a 70% ethanol extract of Daraesoon (400 mg/kg) or acarbose (40 mg/kg) after an overnight fast and their postprandial blood glucose levels were measured. Five-week-old C57BL/6J mice were fed either a basal or high-fat/high-sucrose (HFHS) diet with or without Daraesoon extract (0.4%) or acarbose (0.04%) for 12 weeks after 1 week of adaptation to determine the effects of the chronic consumption of Daraesoon on fasting hyperglycemia and antioxidant status. RESULTS: Compared to the control group, rats that received Daraesoon extract (400 mg/kg) or acarbose (40 mg/kg) exhibited a significant reduction in the area under the postprandial glucose response curve after the oral ingestion of starch. Additionally, the long-term consumption of Daraesoon extract or acarbose significantly decreased serum glucose and insulin levels as well as small intestinal maltase activity in HFHS-fed mice. Furthermore, the consumption of Daraesoon extract significantly reduced thiobarbituric acid reactive substances and increased glutathione levels in the livers of HFHS-fed mice compared to HFHS-fed mice that did not ingest Daraesoon. CONCLUSIONS: Daraesoon effectively suppressed postprandial hyperglycemia via the inhibition of α-glucosidase in STZ-induced diabetic rats. Chronic consumption of Daraesoon alleviated fasting hyperglycemia and oxidative stress in mice fed a HFHS diet.
Abstract
BACKGROUND/OBJECTIVES: The primary objective of the treatment of diabetes mellitus is the attainment of glycemic control. Hyperglycemia increases oxidative stress which contributes to the progression of diabetic complications. Thus, the purpose of this study was to investigate the hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus. MATERIALS/METHODS: Rats with streptozotocin-induced diabetes received an oral administration of a starch solution (1 g/kg) either with or without a 70% ethanol extract of Daraesoon (400 mg/kg) or acarbose (40 mg/kg) after an overnight fast and their postprandial blood glucose levels were measured. Five-week-old C57BL/6J mice were fed either a basal or high-fat/high-sucrose (HFHS) diet with or without Daraesoon extract (0.4%) or acarbose (0.04%) for 12 weeks after 1 week of adaptation to determine the effects of the chronic consumption of Daraesoon on fasting hyperglycemia and antioxidant status. RESULTS: Compared to the control group, rats that received Daraesoon extract (400 mg/kg) or acarbose (40 mg/kg) exhibited a significant reduction in the area under the postprandial glucose response curve after the oral ingestion of starch. Additionally, the long-term consumption of Daraesoon extract or acarbose significantly decreased serum glucose and insulin levels as well as small intestinal maltase activity in HFHS-fed mice. Furthermore, the consumption of Daraesoon extract significantly reduced thiobarbituric acid reactive substances and increased glutathione levels in the livers of HFHS-fed mice compared to HFHS-fed mice that did not ingest Daraesoon. CONCLUSIONS: Daraesoon effectively suppressed postprandial hyperglycemia via the inhibition of α-glucosidase in STZ-induced diabetic rats. Chronic consumption of Daraesoon alleviated fasting hyperglycemia and oxidative stress in mice fed a HFHS diet.
참고문헌 (40)
- Shaw JE, "Global estimates of the prevalence of diabetes for 2010 and 2030", Diabetes Res Clin Pract, 87, pp.4~14 (2010)
- Rahati S, "Food pattern, lifestyle and diabetes mellitus", Int J High Risk Behav Addict, 3, pp.e8725~ (2014)
- "The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group", N Engl J Med, 329, pp.977~986 (1993)
- Standl E, "Effect of acarbose on additional insulin therapy in type 2 diabetic patients with late failure of sulphonylurea therapy", Diabetes Obes Metab, 1, pp.215~220 (1999)
- Hanefeld M, "The role of acarbose in the treatment of non-insulindependent diabetes mellitus", J Diabetes Complications, 12, pp.228~237 (1998)
- Raptis SA, "Oral hypoglycemic agents: insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers", Exp Clin Endocrinol Diabetes, 109(Suppl 2), pp.S265~S287 (2001)
- Kumar S, "α-Glucosidase inhibitors from plants: a natural approach to treat diabetes", Pharmacogn Rev, 5, pp.19~29 (2011)
- Wang H, "α-Glucosidase and α-amylase inhibitory activities of guava leaves", Food Chem, 123, pp.6~13 (2010)
- Mai TT, "Anti-hyperglycemic activity of an aqueous extract from flower buds of Cleistocalyx operculatus (Roxb.) Merr and Perry", Biosci Biotechnol Biochem, 71, pp.69~76 (2007)
- Deguchi Y, "Effects of extract of guava leaves on the development of diabetes in the db", db mouse and on the postprandial blood glucose of human subjects, 1998, pp.72, 923~931
- Deguchi Y, "Effect of guava tea on postprandial blood glucose and diabetes", Assoc J Jpn Soc Med Use Funct Foods, 3, pp.439~445 (2006)
- "Health functional food" (2014)[URL]
- Kaneto H, "Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance", Int J Biochem Cell Biol, 37, pp.1595~1608 (2005)
- Nishiyama I, "Fruits of the actinidia genus", Adv Food Nutr Res, 52, pp.293~324 (2007)
- Williams MH, "Development and commercialization of 'Baby Kiwi' (Actinidia arguta planch.)", Acta Hortic, 610, pp.81~86 (2003)
- 안해천, "In vitro α-Glucosidase and Pancreatic Lipase Inhibitory Activities and Antioxidants of Samnamul (Aruncus dioicus) during Rehydration and Cooking", Food Science and Biotechnology, 23(4), pp.1287~1293 (2014), 한국식품과학회[DOI]
- Kurakane S, "Anti-diabetic effects of Actinidia arguta polyphenols on rats and KK-Ay mice", Food Sci Technol Res, 17, pp.93~102 (2011)
- Lee J, "Antioxidant, inhibition of α-glucosidase and suppression of nitric oxide production in LPS-induced murine macrophages by different fractions of Actinidia arguta stem", Saudi J Biol Sci, 21, pp.532~538 (2014)
- 권도단, "Pinoresinol Diglucoside is Screened as a Putative α-Glucosidase Inhibiting Compound in Actinidia arguta leaves", Applied Biological Chemistry, 57(4), pp.473~479 (2014), 한국응용생명화학회
- 곽충실, "달맞이순과 다래순 에탄올 추출물의 in vitro 항산화효과 및 항염증효과", 한국식품영양과학회지, 43(2), pp.207~215 (2014), 한국식품영양과학회
- 주희정, "The Hypoglycemic Effect of Saururus chinensis Baill in Animal Modelsof Diabetes Mellitus", Food Science and Biotechnology, 15(3), pp.413~417 (2006), 한국식품과학회
- Ali KM, "Inhibitory effect of hydro-methanolic extract of seed of Holarrhena antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat", J Ethnopharmacol, 135, pp.194~196 (2011)
- Surwit RS, "Diet-induced type II diabetes in C57BL", 6J mice, 1988, pp.37, 1163~1167
- 최한율, "Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet", Nutrition Research and Practice, 8(5), pp.544~549 (2014), 한국영양학회
- Folin O, "On phosphotungstic-phosphomolybdic compounds as color reagents", J Biol Chem, 12, pp.239~243 (1912)
- Raabo E, "On the enzymatic determination of blood glucose", Scand J Clin Lab Invest, 12, pp.402~407 (1960)
- Haffner SM, "The homeostasis model in the San Antonio Heart Study", Diabetes Care, 20, pp.1087~1092 (1997)
- Dahlqvist A, "Assay of intestinal disaccharidases", Scand J Clin Lab Invest, 44, pp.169~172 (1984)
- Lowry OH, "Protein measurement with the Folin phenol reagent", J Biol Chem, 193, pp.265~275 (1951)
- Ohkawa H, "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction", Anal Biochem, 95, pp.351~358 (1979)
- Ellman GL, "Tissue sulfhydryl groups", Arch Biochem Biophys, 82, pp.70~77 (1959)
- Woerle HJ, "Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes: Importance of postprandial glycemia to achieve target HbA1c levels", Diabetes Res Clin Pract, 77, pp.280~285 (2007)
- Yang ZH, "Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice", Diabetol Metab Syndr, 4, pp.32~ (2012)
- Liu L, "Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study", Naunyn Schmiedebergs Arch Pharmacol, 381, pp.371~381 (2010)
- Carrascosa JM, "Effects of chronic treatment with acarbose on glucose and lipid metabolism in obese diabetic Wistar rats", Diabetes Obes Metab, 3, pp.240~248 (2001)
- Fujita H, "Fermented soybean-derived Touchi-extract with anti-diabetic effect via alpha-glucosidase inhibitory action in a long-term administration study with KKAy mice", Life Sci, 70, pp.219~227 (2001)
- Meneilly GS, "Effect of acarbose on insulin sensitivity in elderly patients with diabetes", Diabetes Care, 23, pp.1162~1167 (2000)
- Townsend DM, "The importance of glutathione in human disease", Biomed Pharmacother, 57, pp.145~155 (2003)
- Stevenson DE, "Polyphenolic phytochemicals-just antioxidants or much more?", Cell Mol Life Sci, 64, pp.2900~2916 (2007)
- Moskaug JØ, "Polyphenols and glutathione synthesis regulation", Am J Clin Nutr, 81, pp.277S~283S (2005)