Macronutrient composition of human milk from Korean mothers of full term infants born at 37-42 gestational weeks
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초록
BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; 32.0 ± 3.3 years), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.
Abstract
BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; 32.0 ± 3.3 years), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.
참고문헌 (47)
- Ballard O, "Human milk composition: nutrients and bioactive factors", Pediatr Clin North Am, 60, pp.49~74 (2013)
- Isaacs EB, "Impact of breast milk on intelligence quotient, brain size, and white matter development", Pediatr Res, 67, pp.357~362 (2010)
- Kramer MS, "Breastfeeding and child cognitive development: new evidence from a large randomized trial", Arch Gen Psychiatry, 65, pp.578~584 (2008)
- Global Strategy for Infant and Young Child Feeding, "World Health Organization (CH)", World Health Organization, ~ (2003)
- "Infant and young child feeding" (2014)[URL]
- Section on Breastfeeding, "Breastfeeding and the use of human milk", Pediatrics, 129, pp.e827~e841 (2012)
- "Infant feeding recommendation" (2003)[URL]
- Manual of Pediatric Physical Examination 2015, "Ministry of Health and Welfare, Korea Center for Disease Prevention and Control", Korea Center for Disease Prevention and Control, ~ (2015)
- Kim SG, "The 2012 National Survey on Fertility, Family Health & Welfare in Korea", pp.415~441 (2012), Korea Institute for Health and Social Affairs
- 이원석, "육아교실 데이터베이스를 이용한 최근 6년간 한국 6개월 이하 영아의 모유수유 율", Neonatal medicine, 20(2), pp.221~227 (2013), 대한신생아학회
- "Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, ~ (2014)
- Yang T, "Breast milk macronutrient composition and the associated factors in urban Chinese mothers", Chin Med J (Engl), 127, pp.1721~1725 (2014)
- Abranches AD, "Freezing and thawing effects on fat, protein, and lactose levels of human natural milk administered by gavage and continuous infusion", J Pediatr (Rio J), 90, pp.384~388 (2014)
- Quinn EA, "Predictors of breast milk macronutrient composition in Filipino mothers", Am J Hum Biol, 24, pp.533~540 (2012)
- Thakkar SK, "Dynamics of human milk nutrient composition of women from Singapore with a special focus on lipids", Am J Hum Biol, 25, pp.770~779 (2013)
- Lee JS, "Changes in specific gravity, total solid and protein contents of human milk during the course of lactation in Korean women", Korean J Nutr, 21, pp.129~133 (1988)
- Lee SG, "Lipid content of breast milk in Korean women", J Korean Pediatr Soc, 28, pp.977~988 (1985)
- Kim SK, "Quantitative determination of lipids in breast milk of Korean woman", J Korean Pediatr Soc, 29, pp.67~74 (1986)
- Song SW, "Ecological study of the changes in the components of human milk during the breast feeding and the relationships between the dietary behavior of lactating women and the growth of breastfed infants: I. A study on the nitrogen content in human milk", Korean J Nutr, 23, pp.179~186 (1990)
- Choi MH, "An ecological study of changes in the components of human milk during the breast feeding and the relationships between the dietary behavior of lactating women and the growth of breast-fed infants: II. A study on the lipids content in human milk", Korean J Nutr, 24, pp.77~86 (1991)
- Moon SJ, "A longitudinal study of the total nitrogen, total lipid, and lactose contents in human milk and energy intake of breast-fed infants", Korean J Nutr, 25, pp.233~247 (1992)
- Michaelsen KF, "Infrared analysis for determining macronutrients in human milk", J Pediatr Gastroenterol Nutr, 7, pp.229~235 (1988)
- de Halleux V, "Advantages of individualized fortification of human milk for preterm infants", Arch Pediatr, 14(Suppl 1), pp.S5~S10 (2007)
- 민경복, "한국인 모유의 영양소와 영아의 성장과의 관계 분석 연구", 대한주산의학회잡지, 23(4), pp.259~265 (2012), 대한주산의학회
- Corvaglia L, "Near-infrared reflectance analysis to evaluate the nitrogen and fat content of human milk in neonatal intensive care units", Arch Dis Child Fetal Neonatal Ed, 93, pp.F372~F375 (2008)
- Casadio YS, "Evaluation of a mid-infrared analyzer for the determination of the macronutrient composition of human milk", J Hum Lact, 26, pp.376~383 (2010)
- Menjo A, "Bedside analysis of human milk for adjustable nutrition strategy", Acta Paediatr, 98, pp.380~384 (2009)
- Lönnerdal B, "Breast milk composition in Ethiopian and Swedish mothers. II. Lactose, nitrogen, and protein contents", Am J Clin Nutr, 29, pp.1134~1141 (1976)
- Ding M, "Amino acid composition of lactating mothers' milk and confinement diet in rural North China", Asia Pac J Clin Nutr, 19, pp.344~349 (2010)
- Morita A, "Dietary reference intakes for Japanese 2010: lifestage", J Nutr Sci Vitaminol (Tokyo), 59(Suppl), pp.S103~S109 (2013)
- Nommsen LA, "Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study", Am J Clin Nutr, 53, pp.457~465 (1991)
- Prentice AM, "Body mass index and lactation performance", Eur J Clin Nutr, 48(Suppl 3), pp.S78~S86 (1994)
- Innis SM, "Human milk and formula fatty acids", J Pediatr, 120, pp.S56~S61 (1992)
- Mitoulas LR, "Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation", Br J Nutr, 88, pp.29~37 (2002)
- Kent JC, "Volume and frequency of breastfeedings and fat content of breast milk throughout the day", Pediatrics, 117, pp.e387~e395 (2006)
- Chang YC, "The macronutrients in human milk change after storage in various containers", Pediatr Neonatol, 53, pp.205~209 (2012)
- Miller EM, "Field and laboratory methods in human milk research", Am J Hum Biol, 25, pp.1~11 (2013)
- "Comparative lactation - humans" (2009)[URL]
- Koletzko B, "Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group", J Pediatr Gastroenterol Nutr, 41, pp.584~599 (2005)
- Butte NF, "Nutrient adequacy of exclusive breastfeeding for the term infant during the first six months of life" (2002), World Health Organization
- "Collate and review data on the composition and volume and intake of breast milk: results from a systematic literature review"[URL]
- 정성훈, "Trends of Breastfeeding Rate in Korea (1994-2012): Comparison with OECD and Other Countries", Journal of Korean Medical Science, 28(11), pp.1573~1580 (2013), 대한의학회
- Kim HR, "Trends of breastfeeding in Korea and other nations:strategic policy for improving breastfeeing in Korea", Issue Focus, 86, pp.1~8 (2011)
- Pei X, "The China melamine milk scandal and its implications for food safety regulation", Food Policy, 36, pp.412~420 (2011)
- "Botulism threat to infant milk formula" (2013)[URL]
- National Health Plan 2020, "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2011)
- 김정윤, "대한소아과학회 홈페이지의 모유수유 상담내용 분석", Korean Journal of Pediatrics, 51(11), pp.1152~1157 (2008), 대한소아과학회