본문 바로가기
KERD
논문KCI 등재

Mechanism of Ischemic Mitral Regurgitation

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

Augmented leaflet tethering due to the outward displacement of the PMs with LV remodeling appears to be a basic mechanism for ischemic MR. Further, annular dilatation and LV dysfunction likely contribute to the development of MR in the presence of augmented tethering. PM dysfunction per se does not usually cause ischemic MR and may occasionally attenuate tethering and MR. The concept of PM dyssynchrony is important and further study to separate effects of PM dyssynchrony from other factors are required. Although surgical annuloplasty is often effective in reversing ischemic MR, the frequency of patients with persistent or recurrent ischemic MR after surgical ring annuloplasty even with advanced down sizing suggests the need for approaches to address tethering. Finally, leaflet tethering in patients with ischemic MR can vary within a single patient and between patients, indicating the multiple and individualized approaches may be required to correct ischemic MR in affected patients.

Abstract

Augmented leaflet tethering due to the outward displacement of the PMs with LV remodeling appears to be a basic mechanism for ischemic MR. Further, annular dilatation and LV dysfunction likely contribute to the development of MR in the presence of augmented tethering. PM dysfunction per se does not usually cause ischemic MR and may occasionally attenuate tethering and MR. The concept of PM dyssynchrony is important and further study to separate effects of PM dyssynchrony from other factors are required. Although surgical annuloplasty is often effective in reversing ischemic MR, the frequency of patients with persistent or recurrent ischemic MR after surgical ring annuloplasty even with advanced down sizing suggests the need for approaches to address tethering. Finally, leaflet tethering in patients with ischemic MR can vary within a single patient and between patients, indicating the multiple and individualized approaches may be required to correct ischemic MR in affected patients.

참고문헌 (74)

  1. Tcheng JE, "Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction", Ann Intern Med, 117, pp.18~24 (1992)
  2. Lehmann KG, "Mitral regurgitation in early myocardial infarction. Incidence, clinical detection, and prognostic implications. TIMI Study Group", Ann Intern Med, 117, pp.10~17 (1992)
  3. Lamas GA, "Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators", Circulation, 96, pp.827~833 (1997)
  4. Grigioni F, "Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment", Circulation, 103, pp.1759~1764 (2001)
  5. Kisanuki A, "Two-dimensional echocardiographic assessment of papillary muscle contractility in patients with prior myocardial infarction", J Am Coll Cardiol, 21, pp.932~938 (1993)
  6. Ogawa S, "Cross-sectional echocardiographic spectrum of papillary muscle dysfunction", Am Heart J, 97, pp.312~321 (1979)
  7. Godley RW, "Incomplete mitral leaflet closure in patients with papillary muscle dysfunction", Circulation, 63, pp.565~571 (1981)
  8. Otsuji Y, "Insights from three-dimensional echocardiography into the mechanism of functional mitral regurgitation: direct in vivo demonstration of altered leaflet tethering geometry", Circulation, 96, pp.1999~2008 (1997)
  9. Yiu SF, "Determinants of the degree of functional mitral regurgitation in patients with systolic left ventricular dysfunction: A quantitative clinical study", Circulation, 102, pp.1400~1406 (2000)
  10. Otsuji Y, "Isolated annular dilation does not usually cause important functional mitral regurgitation: comparison between patients with lone atrial fibrillation and those with idiopathic or ischemic cardiomyopathy", J Am Coll Cardiol, 39, pp.1651~1656 (2002)
  11. Kaul S, "Mechanism of ischemic mitral regurgitation. An experimental evaluation", Circulation, 84, pp.2167~2180 (1991)
  12. Dent JM, "Mechanism of mitral leaflet excursion", Am J Physiol, 269, pp.H2100~H2108 (1995)
  13. He S, "Integrated mechanism for functional mitral regurgitation: leaflet restriction versus coapting force: in vitro studies", Circulation, 96, pp.1826~1834 (1997)
  14. Otsuji Y, "Mechanism of ischemic mitral regurgitation with segmental left ventricular dysfunction: three-dimensional echocardiographic studies in models of acute and chronic progressive regurgitation", J Am Coll Cardiol, 37, pp.641~648 (2001)
  15. Llaneras MR, "Pathogenesis of ischemic mitral insufficiency", J Thorac Cardiovasc Surg, 105, pp.439~442 (1993), discussion 442-3
  16. Gorman RC, "Pathogenesis of acute ischemic mitral regurgitation in three dimensions", J Thorac Cardiovasc Surg, 109, pp.684~693 (1995)
  17. Komeda M, "Geometric determinants of ischemic mitral regurgitation", Circulation, 96(II), pp.II-128~II-133 (1997)
  18. Kono T, "Mechanism of functional mitral regurgitation during acute myocardial ischemia", J Am Coll Cardiol, 19, pp.1101~1105 (1992)
  19. Sabbah HN, "Left ventricular shape: a factor in the etiology of functional mitral regurgitation in heart failure", Am Heart J, 123, pp.961~966 (1992)
  20. Izumi S, "Mechanism of mitral regurgitation in patients with myocardial infarction: a study using real-time two-dimensional Doppler flow imaging and echocardiography", Circulation, 76, pp.777~785 (1987)
  21. Leor J, "Effect of thrombolytic therapy on the evolution of significant mitral regurgitation in patients with a first inferior myocardial infarction", J Am Coll Cardiol, 21, pp.1661~1666 (1993)
  22. Gorman JH, "Infarct size and location determine development of mitral regurgitation in the sheep model", J Thorac Cardiovasc Surg, 115, pp.615~622 (1988)
  23. Kumanohoso T, "Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: quantitative analysis of left ventricular and mitral valve geometry in 103 patients with prior myocardial infarction", J Thorac Cardiovasc Surg, 125, pp.135~143 (2003)
  24. Liel-Cohen N, "Design of a new surgical approach for ventricular remodeling to relieve ischemic mitral regurgitation: insights from 3-dimensional echocardiography", irculation, 101, pp.2756~2763 (2000)
  25. Hung J, "Reverse ventricular remodeling reduces ischemic mitral regurgitation:echo-guided device application in the beating heart", Circulation, 106, pp.2594~2600 (2002)
  26. Kron IL, "Surgical relocation of the posterior papillary muscle in chronic ischemic mitral regurgitation", Ann Thorac Surg, 74, pp.600~601 (2002)
  27. Hvass U, "Papillary muscle sling: a new functional approach to mitral repair in patients with ischemic left ventricular dysfunction and functional mitral regurgitation", Ann Thorac Surg, 75, pp.809~811 (2003)
  28. Dobre M, "Anatomic and physiologic correction of the restricted posterior mitral leaflet motion in chronic ischemic mitral regurgitation", J Thorac Cardiovasc Surg, 120, pp.409~411 (2000)
  29. Ueno T, "A new surgical approach to reduce tethering in ischemic mitral regurgitation by relocation of separate heads of the posterior papillary muscle", Ann Thorac Surg (in press), ~
  30. Schwammenthal E, "Dynamics of mitral regurgitant flow and orifice area. Physiologic application of the proximal flow convergence method: clinical data and experimental testing", Circulation, 90, pp.307~322 (1994)
  31. Hung J, "Mechanism of dynamic regurgitant orifice area variation in functional mitral regurgitation: physiologic insights from the proximal flow convergence technique", J Am Coll Cardiol, 33, pp.538~545 (1999)
  32. Breithardt OA, "Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure", J Am Coll Cardiol, 41, pp.765~770 (2003)
  33. Fukuda S, "Electrical conduction disturbance effects on dynamic changes of functional mitral regurgitation", J Am Coll Cardiol, 46, pp.2270~2276 (2005)
  34. Burch GE, "Clinical manifestations of papillary muscle dysfunction", Arch Intern Med, 112, pp.112~117 (1963)
  35. Burch GE, "The syndrome of papillary muscle dysfunction", Am Heart J, 75, pp.399~415 (1968)
  36. Hider CF, "The effect of papillary muscle damage on atrioventricular valve function in the left heart", Q J Exp Physiol Cogn Med Sci, 50, pp.15~22 (1965)
  37. Miller GE Jr, "Experimental papillary muscle infarction", J Thorac Cardiovasc Surg, 56, pp.611~616 (1968)
  38. Tsakiris AG, "Effect of experimental papillary muscle damage on mitral valve closure in intact anesthetized dogs", Mayo Clin Proc, 45, pp.275~285 (1970)
  39. Mittal AK, "Combined papillary muscle and left ventricular wall dysfunction as a cause of mitral regurgitation. An experimental study", Circulation, 44, pp.174~180 (1971)
  40. Matsuzaki M, "Experimental mitral regurgitation in ischemia-induced papillary muscle dysfunction", J Cardiol, 18, pp.121~126 (1988)
  41. Messas E, "Paradoxic decrease in ischemic mitral regurgitation with papillary muscle dysfunction: insights from three-dimensional and contrast echocardiography with strain rate measurement", Circulation, 104, pp.1952~1957 (2001)
  42. Uemura T, "Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling: insights from tissue Doppler strain imaging", J Am Coll Cardiol (in press), ~
  43. Fundaro P, "Posterior mitral valve restoration for ischemic regurgitation", Ann Thorac Surg, 77, pp.729~730 (2004)
  44. Jouan J, "Ischemic mitral valve prolapse: mechanisms and implications for valve repair", Eur J Cardiothorac Surg, 26, pp.1112~1117 (2004)
  45. Tei C, "Mitral valve prolapse in short-term experimental coronary occlusion:a possible mechanism of ischemic mitral regurgitation", Circulation, 68, pp.183~189 (1983)
  46. Kanzaki H, "A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization therapy: insights from mechanical activation strain mapping", J Am Coll Cardiol, 44, pp.1619~1625 (2004)
  47. Ypenburg C, "Acute effects of initiation and withdrawal of cardiac resynchronization therapy on papillary muscle dyssynchrony and mitral regurgitation", J Am Coll Cardiol, 50, pp.2071~2077 (2007)
  48. Ahmad RM, "Cosgrove DM. Annular geometry and motion in human ischemic mitral regurgitation: novel assessment with three-dimensional echocardiography and computer reconstruction", Ann Thorac Surg, 78, pp.2063~2068 (2004)
  49. Tibayan FA, "Geometric distortions of the mitral valvular-ventricular complex in chronic ischemic mitral regurgitation", Circulation, 108(1), pp.II116~II121 (2003)
  50. Green GR, "Mitral annular dilatation and papillary muscle dislocation without mitral regurgitation in sheep", Circulation, 100, pp.1195~1102 (1999)
  51. Boltwood CM, "Quantitative echocardiography of the mitral complex in dilated cardiomyopathy: the mechanism of functional mitral regurgitation", Circulation, 68, pp.498~508 (1983)
  52. Chandraratna PAN, "Mitral valve ring in normal vs dilated left ventricle: cross-sectional echocardiographic study", Chest, 79, pp.151~154 (1981)
  53. Calafiore AM, "Mitral valve procedure in dilated cardiomyopathy: repair or replacement?", Ann Thorac Surg, 71, pp.1146~1152 (2001)
  54. Tahta SA, "Outcome after mitral valve repair for functional ischemic mitral regurgitation", J Heart Valve Dis, 11, pp.11~18 (2002)
  55. McGee Jr EC, "Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation", J Thorac Cardiovasc Surg, 128, pp.916~924 (2004)
  56. Hung J, "Mechanism of recurrent ischemic mitral regurgitation after annuloplasty: continued LV remodeling as a moving target", Circulation, 110(11), pp.II85~II90 (2004)
  57. Sanfilippo AJ, "Atrial enlargement as a consequence of atrial fibrillation:a prospective echocardiographic study", Circulation, 82, pp.792~797 (1990)
  58. Levine RA, "Three-dimensional echocardiographic reconstruction of the mitral valve, with implications for the diagnosis of mitral valve prolapse", Circulation, 80, pp.589~598 (1989)
  59. Flachskampf FA, "Analysis of shape and motion of the mitral annulus in subjects with and without cardiomyopathy by echocardiographic 3-dimensional reconstruction", J Am Soc Echocardiogr, 13, pp.277~287 (2000)
  60. Gorman JH 3rd, "The effect of regional ischemia on mitral valve annular saddle shape", Ann Thorac Surg, 77, pp.544~548 (2004)
  61. Bolling SF, "Intermediate-term outcome of mitral reconstruction in cardiomyopathy", J Thorac Cardiovasc Surg, 115, pp.381~386 (1998)
  62. Bach DS, "Improvement following correction of secondary mitral regurgitation in end-stage cardiomyopathy with mitral annuloplasty", Am J Cardiol, 78, pp.966~969 (1996)
  63. Bach DS, "Early improvement in congestive heart failure after correction of secondary mitral regurgitation in end-stage cardiomyopathy", Am Heart J, 129, pp.1165~1170 (1995)
  64. Bax JJ, "Restrictive annuloplasty and coronary revascularization in ischemic mitral regurgitation results in reverse left ventricular remodeling", Circulation, 110(11), pp.II103~II108 (2004)
  65. Weyman AE, "Part 2 Clinical applications, 17 left ventricular inflow tract I: the mitral valve", pp.457~ (1994), Lea & Febiger
  66. Nesta F, "Leaflet concavity: a rapid visual clue to the presence and mechanism of functional mitral regurgitation", J Am Soc Echocardiogr, 16, pp.1301~1308 (2003)
  67. Messas E, "Chordal cutting: a new therapeutic approach for ischemic mitral regurgitation", Circulation, 104, pp.1958~1963 (2001)
  68. Messas E, "Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation", Circulation, 108(1), pp.II111~II115 (2003)
  69. Kwan J, "Real-time threedimensional echocardiography study. Geometric differences of the mitral apparatus between ischemic and dilated cardiomyopathy with significant mitral regursgitation: real-time three-dimensional echocardiography study", Circulation, 107, pp.1135~1140 (2003)
  70. Zhang H, "Different mechanisms of ischemic mitral regurgitation in patients with anterior and inferior myocardial infarction", Circulation, 108(IV), pp.IV-432~ (2003)
  71. Watanabe N, "Geometric differences of the mitral valve tenting between anterior and inferior myocardial infarction with significant ischemic mitral regurgitation: quantitation by novel software system with transthoracic real-time three-dimensional echocardiography", J Am Soc Echocardiogr, 19, pp.71~75 (2006)
  72. Zhu F, "Mechanism of persistent ischemic mitral regurgitation following annuloplasty:importance of augmented posterior mitral leaflet tethering", Circulation, 112(I), pp.I-396~I-401 (2005)
  73. Kuwahara E, "Mechanism of Recurrent", Persistent Ischemic, Circulation, pp.2006, 114(I)[DOI]
  74. Watanabe N, "Quantitation of mitral valve tenting in ischemic mitral regurgitation by transthoracic real-time three-dimensional echocardiography", J Am Coll Cardiol, 45, pp.763~769 (2005)

관련 논문AI추천

Assessment of Mitral Valve Complex by Three-Dimensional Echocardiography: Therapeutic Strategy for Functional Mitral RegurgitationKikuko Obase, Kiyoshi Yoshida한국심초음파학회 · Journal of Cardiovascular Imaging2012 · 제20권 제2호Surgical Timing of Degenerative Mitral Regurgitation: What to ConsiderLieng H. Ling, Maria Consolacion Dolor-Torres한국심초음파학회 · Journal of Cardiovascular Imaging2012 · 제20권 제4호A Modified Echocardiographic Classification of Mitral Valve Regurgitation Mechanism: The Role of Three-dimensional EchocardiographyBen Ren, Frans B. Oei, Jackie McGhie, Lotte E. de Groot-de Laat, Marcel L. Geleijnse, René Frowijn한국심초음파학회 · Journal of Cardiovascular Imaging2019 · 제27권 제3호Effects of Decreased Annular Height and Annular Saddle-Shaped Non-Planarity in Degenerative Severe Mitral Regurgitation with Normal Left Ventricular Ejection Fraction: Real-Time 3D Transesophageal Echocardiography김은경, 박성지, 박승우, 박표원, 이가연, 이상철, 장성아, 조은정, 최진오한국심초음파학회 · Journal of Cardiovascular Imaging2017 · 제25권 제2호Role of Dyssynchrony on Functional Mitral Regurgitation in Patients with Idiopathic Dilated Cardiomyopathy: A Comparison Study with Geometric Parameters of Mitral Apparatus권준, 김대혁, 김수현, 박금수, 박상돈, 백영수, 신성희, 우성일, 이우형, 최웅길한국심초음파학회 · Journal of Cardiovascular Imaging2011 · 제19권 제2호Clinical Implication of Mechanical Dyssynchrony in Heart FailureCheuk-Man Yu, Qing Zhang한국심초음파학회 · Journal of Cardiovascular Imaging2012 · 제20권 제3호

이 간행물의 다른 논문 (5건)