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Excessive Weight and Obesity Are Associated to Intra-Ventricular Asynchrony: Pilot Study

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Background: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead toa state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatorystate. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. Theobjective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured byechocardiography, in healthy individuals with EwO. Methods: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m2 (30.9%) and 38 had aBMI > 25 kg/m2 (EwO group) (69.09%), anthropometric measurements, transthoracic echocardiogram and synchrony evaluationwere obtained. Results: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventriclewere greater in the EwO group (20 mL/m2 vs. 15 mL/m2, p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby thegreater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index alsocorrelated with the BMI, p = 0.01. Conclusion: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchronymay be one more factor leading to heart failure in EwO individuals.

Abstract

Background: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead toa state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatorystate. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. Theobjective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured byechocardiography, in healthy individuals with EwO. Methods: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m2 (30.9%) and 38 had aBMI > 25 kg/m2 (EwO group) (69.09%), anthropometric measurements, transthoracic echocardiogram and synchrony evaluationwere obtained. Results: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventriclewere greater in the EwO group (20 mL/m2 vs. 15 mL/m2, p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby thegreater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index alsocorrelated with the BMI, p = 0.01. Conclusion: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchronymay be one more factor leading to heart failure in EwO individuals.

참고문헌 (32)

  1. Mokdad AH, "The spread of the obesity epidemic in the United States, 1991-1998", JAMA, 282, pp.1519~1522 (1999)
  2. Barquera S, "Prevalence of obesity in Mexican adults 2000-2012", Salud Publica Mex, 55(2), pp.151~160 (2013)
  3. Hubert HB, "Obesity as an independent risk factor for cardiovascular disease : a 26-year follow-up of participants in the Framingham Heart Study", Circulation, 67, pp.968~977 (1983)
  4. Chen YT, "Risk factors for heart failure in the elderly : a prospective community-based study", Am J Med, 106, pp.605~612 (1999)
  5. Murphy NF, "Long-term cardiovascular consequences of obesity : 20-year follow-up of more than 15 000 middle-aged men and women(the Renfrew-Paisley study)", Eur Heart J, 27, pp.96~106 (2006)
  6. Ritchie RH, "Evidence for a causal role of oxidative stress in the myocardial complications of insulin resistance", Heart Lung Circ, 18, pp.11~18 (2009)
  7. Iozzo P, "Myocardial, perivascular, and epicardial fat", Diabetes Care, 34(2), pp.371~379 (2011)
  8. Alpert MA, "Obesity cardiomyopathy : pathophysiology and evolution of the clinical syndrome", Am J Med Sci, 321, pp.225~236 (2001)
  9. Kass DA, "An epidemic of dyssynchrony: but what does it mean?", J Am Coll Cardiol, 51, pp.12~17 (2008)
  10. Korosoglou G, "Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart disease", Am J Cardiol, 98, pp.1525~1530 (2006)
  11. Schuster I, "Diastolic dysfunction and intraventricular dyssynchrony are restored by low intensity exercise training in obese men", Obesity, 20, pp.134~140 (2012)
  12. Gorcsan J 3rd, "Echocardiography for cardiac resynchronization therapy : recommendations for performance and reporting--a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society", J Am Soc Echocardiogr, 21, pp.191~213 (2008)
  13. Iacobellis G, "Echocardiographic epicardial fat: a review of research and clinical applications", J Am Soc Echocardiogr, 22, pp.1311~1319 (2009)
  14. Lang RM, "American Society of Echocardiography’s Guidelines and Standards Committee ; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology", J Am Soc Echocardiogr, 18, pp.1440~1463 (2005)
  15. Mor-Avi V, "Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics : ASE", EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography, 2011, pp.12, 167~205
  16. Yu CM, "Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy", Am J Cardiol, 91, pp.684~688 (2003)
  17. Marfella R, "Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women", Diabetes Care, 27, pp.47~52 (2004)
  18. Delcour KS, "Intraventricular mechanical asynchrony in asymptomatic morbidly obese individuals", J Cardiometab Syndr, 2, pp.305~308 (2007)
  19. Kramer SP, "and synchrony in mouse models : a cine displacement encoding with stimulated echoes(DENSE)cardiovascular magnetic resonance study", J Cardiovasc Magn Reson, 15, pp.109~ (2013)
  20. Grines CL, "Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony", Circulation, 79, pp.845~853 (1989)
  21. Zhou YT, "Lipotoxic heart disease in obese rats : implications for human obesity", Proc Natl Acad Sci U S A, 97, pp.1784~1789 (2000)
  22. Chiu HC, "A novel mouse model of lipotoxic cardiomyopathy", J Clin Invest, 107, pp.813~822 (2001)
  23. Sharma S, "Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart", FASEB J, 18, pp.1692~1700 (2004)
  24. Szczepaniak LS, "Myocardial triglycerides and systolic function in humans : in vivo evaluation by localized proton spectroscopy and cardiac imaging", Magn Reson Med, 49, pp.417~423 (2003)
  25. Iozzo P, "Contribution of glucose tolerance and gender to cardiac adiposity", J Clin Endocrinol Metab, 94, pp.4472~4482 (2009)
  26. Messerli FH, "Borderline hypertension and obesity : two prehypertensive states with elevated cardiac output", Circulation, 66, pp.55~60 (1982)
  27. Peterson LR, "Alterations in left ventricular structure and function in young healthy obese women : assessment by echocardiography and tissue Doppler imaging", J Am Coll Cardiol, 43, pp.1399~1404 (2004)
  28. Krishnan R, "Impact of body mass index on markers of left ventricular thickness and mass calculation : results of a pilot analysis", Echocardiography, 22, pp.203~210 (2005)
  29. Di Salvo G, "Abnormal myocardial deformation properties in obese, non-hypertensive children:an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study", Eur Heart J, 27, pp.2689~2695 (2006)
  30. Wierzbowska-Drabik K, "Severe obesity impairs systolic and diastolic heart function - the significance of pulsed tissue Doppler, strain, and strain rate parameters", Echocardiography, 30, pp.904~911 (2013)
  31. Wong C, "Obesity cardiomyopathy : pathogenesis and pathophysiology", Nat Clin Pract Cardiovasc Med, 4, pp.436~443 (2007)
  32. Malavazos AE, "Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity : relationship with abdominal fat deposition", Nutr Metab Cardiovasc Dis, 17, pp.294~302 (2007)

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