관상동맥질환 위험 인자인 심장외막 지방량의 예측시 심초음파 각 단면도의 유용성
Echocardiographic plains reflecting total amount of epicardial adipose tissue as risk factor of coronary artery disease
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Background: Several studies suggested that epicardial adipose tissue (EAT) might be associated with metabolic syndrome and coronary atherosclerosis. But, little had been studied whether the thickness of EAT on echocardiography could represent the whole amount of EAT. The purpose of this study was to identify the best echocardiographic methods reflecting total amount of EAT. Methods: Sixty subjects (32 women, mean: 58±12 years-old) who underwent 64-slice multidetector computed tomography (MDCT) were consecutively enrolled. All CT scanning was performed one Brilliance CT-64-channel configuration scanner (Philips, Cleveland, USA) and axially contiguous 10-mm-thickeness sections were obtained from aortic valve to diaphragm level. EAT area was manually traced in each slice and summed up. The EAT thickness was measured as the echo-lucent or echo-dense space between epicardium and pericardium at parasternal long-axis, modified 4-chamber, and apical 4-chamber view. Results: The EAT thickness at parasternal long-axis and modified 4-chamber view and the sum of EAT thickness from each views (median thickness: 1.0, 2.8, 1.1 and 5.0 mm, respectively) were all correlated with total EAT area on MDCT. Among echo parameters, the EAT thickness measured on parasternal long-axis view during diastole correlated best with total EAT area on MDCT (r=0.572, p＜0.001). Conclusion: The echocardiographic EAT measurement might be easily accessible and less harmful method representing whole amount of EAT. The measurement of the thickness of EAT on parasternal long-axis view during diastole by echocardiography might be feasible and reliable in the studying field of EAT.
Abstract
Background: Several studies suggested that epicardial adipose tissue (EAT) might be associated with metabolic syndrome and coronary atherosclerosis. But, little had been studied whether the thickness of EAT on echocardiography could represent the whole amount of EAT. The purpose of this study was to identify the best echocardiographic methods reflecting total amount of EAT. Methods: Sixty subjects (32 women, mean: 58±12 years-old) who underwent 64-slice multidetector computed tomography (MDCT) were consecutively enrolled. All CT scanning was performed one Brilliance CT-64-channel configuration scanner (Philips, Cleveland, USA) and axially contiguous 10-mm-thickeness sections were obtained from aortic valve to diaphragm level. EAT area was manually traced in each slice and summed up. The EAT thickness was measured as the echo-lucent or echo-dense space between epicardium and pericardium at parasternal long-axis, modified 4-chamber, and apical 4-chamber view. Results: The EAT thickness at parasternal long-axis and modified 4-chamber view and the sum of EAT thickness from each views (median thickness: 1.0, 2.8, 1.1 and 5.0 mm, respectively) were all correlated with total EAT area on MDCT. Among echo parameters, the EAT thickness measured on parasternal long-axis view during diastole correlated best with total EAT area on MDCT (r=0.572, p＜0.001). Conclusion: The echocardiographic EAT measurement might be easily accessible and less harmful method representing whole amount of EAT. The measurement of the thickness of EAT on parasternal long-axis view during diastole by echocardiography might be feasible and reliable in the studying field of EAT.
참고문헌 (14)
- Hyun DW, "Change in coronary blood blow and coronary blood flow reserve after a single high-fat and low-fat meal in patients with ischemic heart disease assessed by transthoracic echocardiography", Kor Soc Echo, pp.24~30 (2003)
- Iacobellis G, "Obesity and the heart: redefinition of the relationship", Obes Res, 8, pp.35~40 (2007)
- Dagenais GR, "Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease", Am Heart J, 149, pp.54~60 (2005)
- Kwon KY, "Clinical significance of visceral adipose tissue", J Korean Acad Fam Med, 28, pp.729~747 (2007)
- Iacobellis G, "Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction", Obese Res, 11, pp.304~310 (2003)
- Jeong GH, "Association between ultrasonographic visceral fat indices and cardiovascular risk factors in type 2 diabetes patients", Korean J Intern Med, 73(6), pp.618~630 (2007)
- Sacks HS, "Human epicardial adipose tissue: a review", Am Heart J, 153, pp.907~917 (2007)
- Ahn SG, "Relationship of Epicardial Adipose Tissue by Echocardiography to Coronary Artery Disease", Heart Heart, 94, pp.e7~ (2008)
- Baik SH, "The relationship of epicardial adipose tissue to metabolic syndrome and cardiovascular risk factors", Korean J Med, 72, pp.245~252 (2007)
- Jeoung JW, "Echocardiographic epicardial fat thickness and coronary artery disease", Circ J, 71, pp.536~539 (2007)
- Flüchter S, "Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonanace imaging", Obesity, 15, pp.870~878 (2007)
- Iacobellis G, "Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome:a new indicator of cardiovascular risk", J Clin Endocrinol Metab, 88, pp.5163~5168 (2003)
- Mazurek T, "Human epicardial adipose tissue is a source of inflammatory mediators", Circulation, 108, pp.2460~2466 (2003)
- Baker AR, "Human epicardial aidpose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease", Cardiovasular Diabetology, 5, pp.1~8 (2006)