High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
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BACKGROUND/OBJECTIVES: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association. SUBJECTS/METHODS: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression. RESULTS: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status. CONCLUSIONS: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted.
Abstract
BACKGROUND/OBJECTIVES: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association. SUBJECTS/METHODS: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression. RESULTS: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status. CONCLUSIONS: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted.
참고문헌 (58)
- Lips P, "Vitamin D and type 2 diabetes", J Steroid Biochem Mol Biol, 173, pp.280~285 (2017)
- Issa CM, "Vitamin D and type 2 diabetes mellitus", Adv Exp Med Biol, 996, pp.193~205 (2017)
- Pittas AG, "The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis", J Clin Endocrinol Metab, 92, pp.2017~2029 (2007)
- Park S, "Maternal vitamin D deficiency in early pregnancy is not associated with gestational diabetes mellitus development or pregnancy outcomes in Korean pregnant women in a prospective study", J Nutr Sci Vitaminol(Tokyo), 60, pp.269~275 (2014)
- Baker AM, "First-trimester maternal vitamin D status and risk for gestational diabetes(GDM)a nested case-control study", Diabetes Metab Res Rev, 28, pp.164~168 (2012)
- Loy SL, "Association of maternal Vitamin D status with glucose tolerance and caesarean section in a multi-ethnic Asian cohort : the growing up in Singapore towards healthy outcomes study", PLoS One, 10, pp.e0142239~ (2015)
- Rodriguez A, "Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes", BJOG, 122, pp.1695~1704 (2015)
- Hauta-Alus HH, "Maternal vitamin D status, gestational diabetes and infant birth size", BMC Pregnancy Childbirth, 17, pp.420~429 (2017)
- Lacroix M, "Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus", Acta Diabetol, 51, pp.609~616 (2014)
- Al-Ajlan A, "Lower vitamin D levels in Saudi pregnant women are associated with higher risk of developing GDM", BMC Pregnancy Childbirth, 18, pp.86~93 (2018)
- Wang O, "Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women", Biomed Environ Sci, 25, pp.399~406 (2012)
- Xu C, "Maternal early pregnancy plasma concentration of 25-hydroxyvitamin D and risk of gestational diabetes mellitus", Calcif Tissue Int, 102, pp.280~286 (2018)
- Arnold DL, "Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus", Paediatr Perinat Epidemiol, 29, pp.200~210 (2015)
- Poel YH, "Vitamin D and gestational diabetes : a systematic review and meta-analysis", Eur J Intern Med, 23, pp.465~469 (2012)
- Wei SQ, "Maternal vitamin D status and adverse pregnancy outcomes : a systematic review and meta-analysis", J Matern Fetal Neonatal Med, 26, pp.889~899 (2013)
- Burris HH, "Vitamin D deficiency in pregnancy and gestational diabetes mellitus", Am J Obstet Gynecol, 207, pp.182~ (2012)
- Alvarez JA, "Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis", Int J Endocrinol, 2010, pp.351385~ (2010)
- Sung CC, "Role of vitamin D in insulin resistance", J Biomed Biotechnol, 2012, pp.634195~ (2012)
- Evans KN, "Vitamin D and placental-decidual function", J Soc Gynecol Investig, 11, pp.263~271 (2004)
- Eguchi K, "Islet inflammation in type 2 diabetes and physiology", J Clin Invest, 127, pp.14~23 (2017)
- Szymczak-Pajor I, "The molecular mechanisms by which vitamin D prevents insulin resistance and associated disorders", Int J Mol Sci, 21, pp.6644~ (2020)
- Prietl B, "Vitamin D and immune function", Nutrients, 5, pp.2502~2521 (2013)
- Charoenngam N, "Immunologic effects of vitamin D on human health and disease", Nutrients, 12, pp.2097~ (2020)
- Shymanskyi I, "Vitamin D deficiency and diabetes mellitus" (2020), IntechOpen
- "National Obstetrics Registry: 5th Report, Jan 2016–Dec 2017" (2020)[URL]
- Preliminary Report of National Obstetrics Registry, Jan–December 2010, "Jeganathan R", Jointly published by the National Obstetrics Registry and the Clinical Research Centre (CRC), Ministry of Health Malaysia, ~ (2013)
- Logakodie S, "Gestational diabetes mellitus : the prevalence, associated factors and foeto-maternal outcome of women attending antenatal care", Malays Fam Physician, 12, pp.9~17 (2017)
- Tan PC, "Screening for gestational diabetes at antenatal booking in a Malaysian university hospital : the role of risk factors and threshold value for the 50-g glucose challenge test", Aust N Z J Obstet Gynaecol, 47, pp.191~197 (2007)
- Jan Mohamed HJ, "Maternal serum and breast milk vitamin D levels : findings from the Universiti Sains Malaysia Pregnancy Cohort Study", PLoS One, 9, pp.e100705~ (2014)
- Bukhary NB, "Risk factors for antenatal hypovitaminosis D in an urban district in Malaysia", BMC Pregnancy Childbirth, 16, pp.156~166 (2016)
- Mousa A, "Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin", Mol Nutr Food Res, 61, pp.1700488~ (2017)
- Yong HY, "Seremban Cohort Study(SECOST) : a prospective study of determinants and pregnancy outcomes of maternal glycaemia in Malaysia", BMJ Open, 8, pp.e018321~ (2018)
- Palaniveloo L, "Vitamin D status is associated with high BMI, working status and gravidity among pregnant Malaysian women", Malays J Nutr, 26, pp.129~139 (2020)
- Institute of Medicine, "Dietary Reference Intakes for Calcium and Vitamin D" (2011), The National Academies Press;
- "Perinatal Care Manual 3rd Edition" (2013)[URL]
- Obesity: preventing and managing the global epidemic. Report of a WHO consultation, , i~253, pp.World Health Organ Tech Rep Ser 894 (2000)
- First DataBank, "Nutritionist Pro", First DataBank, ~ (2005)
- U.S. Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Nutrient Data Laboratory, "USDA National Nutrient Database for Standard Reference, Release 28", Nutrient Data Laboratory, ~ (2016)
- Recommended Nutrient Intakes for Malaysia: A Report of the Technical Working Group on Nutritional Guidelines, "Ministry of Health Malaysia", Ministry of Health Malaysia, ~ (2017)
- Chasan-Taber L, "Development and validation of a Pregnancy Physical Activity Questionnaire", Med Sci Sports Exerc, 36, pp.1750~1760 (2004)
- IBM Corp, "IBM SPSS Statistics 25.0 for Windows, Released 2020", IBM Corp, ~ (2020)
- Szumilas M, "Explaining odds ratios", J Can Acad Child Adolesc Psychiatry, 19, pp.227~229 (2010)
- Chiefari E, "Gestational diabetes mellitus : an updated overview", J Endocrinol Invest, 40, pp.899~909 (2017)
- Cozzolino M, "Analysis of the main risk factors for gestational diabetes diagnosed with International Association of Diabetes and Pregnancy Study Groups(IADPSG)criteria in multiple pregnancies", J Endocrinol Invest, 40, pp.937~943 (2017)
- Yang X, "Gestational diabetes mellitus in women of single gravidity in Tianjin City, China", Diabetes Care, 25, pp.847~851 (2002)
- Yang H, "Risk factors for gestational diabetes mellitus in Chinese women : a prospective study of 16, 286 pregnant women in China", Diabet Med, 26, pp.1099~1104 (2009)
- Di Cianni G, "Prevalence and risk factors for gestational diabetes assessed by universal screening", Diabetes Res Clin Pract, 62, pp.131~137 (2003)
- Erem C, "Prevalence of gestational diabetes mellitus and associated risk factors in Turkish women : the Trabzon GDM Study", Arch Med Sci, 11, pp.724~735 (2015)
- Castro AV, "Obesity, insulin resistance and comorbidities? Mechanisms of association", Arq Bras Endocrinol Metabol, 58, pp.600~609 (2014)
- Kwak SH, "A genome-wide association study of gestational diabetes mellitus in Korean women", Diabetes, 61, pp.531~541 (2012)
- Flood-Nichols SK, "Vitamin D deficiency in early pregnancy", PLoS One, 10, pp.e0123763~ (2015)
- Pérez-López FR, "First trimester serum 25-hydroxyvitamin D status and factors related to lower levels in gravids living in the Spanish Mediterranean coast", Reprod Sci, 18, pp.730~736 (2011)
- Leffelaar ER, "Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth : results of the multi-ethnic Amsterdam Born Children and their Development cohort", Br J Nutr, 104, pp.108~117 (2010)
- Ates S, "Vitamin D status in the first-trimester : effects of vitamin D deficiency on pregnancy outcomes", Afr Health Sci, 16, pp.36~43 (2016)
- Song SJ, "The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing", PLoS One, 8, pp.e85081~ (2013)
- Holick MF, "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline", J Clin Endocrinol Metab, 96, pp.1911~1930 (2011)
- Yong HY, "Pre-pregnancy BMI and intake of energy and calcium are associated with the vitamin D intake of pregnant Malaysian women", Fam Med Prim Care Rev, 19, pp.417~423 (2017)
- Huang TT, "Effect of screening out implausible energy intake reports on relationships between diet and BMI", Obes Res, 13, pp.1205~1217 (2005)