Prevalence of Pulmonary Arterial Hypertension in Korean Adult Patients with Systemic Sclerosis: Result of a Pilot Echocardiographic Screening Study
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Background: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with systemicsclerosis (SSc). Early detection and prompt treatment of PAH associated with SSc (SSc-PAH) result in better prognosis. Weconducted echocardiographic study to presume the prevalence of PAH in Korean adult SSc patients and to diagnose SSc-PAH intheir early stages with right heart catheterization (RHC). Methods: We performed free of charge echocardiographic study including 37 adult SSc patients at the Chungnam NationalUniversity Hospital. The possibility of PAH is determined by the estimation of pulmonary arterial pressure by peak tricuspid regurgitationvelocity of > 3.0 m/s. Patients with possible PAH were recommended to undergo RHC to confirm the diagnosis. Results: In 37 patients, 8 patients were suspected with PAH. Among them, 6 patients agreed to be examined with RHC, and4 were confirmed with PAH. The prevalence of possible PAH was 21.6% (8 of 37 patients), and that of confirmed PAH was10.8% (4 of 37 patients). Four patients who were confirmed with SSc-PAH through RHC have been treated with specific pulmonaryvasodilators and maintained stable. Conclusion: Eight patients (21.6%) were possible PAH and 4 (10.8%) were diagnosed as SSc-PAH by RHC after the echocardiographicscreening study of 37 adult SSc patients.
Abstract
Background: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with systemicsclerosis (SSc). Early detection and prompt treatment of PAH associated with SSc (SSc-PAH) result in better prognosis. Weconducted echocardiographic study to presume the prevalence of PAH in Korean adult SSc patients and to diagnose SSc-PAH intheir early stages with right heart catheterization (RHC). Methods: We performed free of charge echocardiographic study including 37 adult SSc patients at the Chungnam NationalUniversity Hospital. The possibility of PAH is determined by the estimation of pulmonary arterial pressure by peak tricuspid regurgitationvelocity of > 3.0 m/s. Patients with possible PAH were recommended to undergo RHC to confirm the diagnosis. Results: In 37 patients, 8 patients were suspected with PAH. Among them, 6 patients agreed to be examined with RHC, and4 were confirmed with PAH. The prevalence of possible PAH was 21.6% (8 of 37 patients), and that of confirmed PAH was10.8% (4 of 37 patients). Four patients who were confirmed with SSc-PAH through RHC have been treated with specific pulmonaryvasodilators and maintained stable. Conclusion: Eight patients (21.6%) were possible PAH and 4 (10.8%) were diagnosed as SSc-PAH by RHC after the echocardiographicscreening study of 37 adult SSc patients.
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