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금앵자(金櫻子)추출물이 과산화지질을 급여한 흰쥐의 혈청지질구성과 항산화능에 미치는 영향

Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on Serum Lipid Composition and Antioxidative Capacity in Rats Fed High Oxidized Fat

이은|임상철|박영훈
한국자원식물학회 (The Plant Resources Society Of Korea)|2004.10|한국자원식물학회지 (Korean Journal of Plant Reources.)|제17권 제3호|pp. 323-330

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Abstract

Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Twenty eight male Sprague-Dawley rats weighing 159.35 ± 2.17 g were blocked into four groups according to body weight and raised seven weeks with basal diet (normal group, Ⅰ), basal diet and 10% oxidized fat (control group, Ⅱ), basal diet, 10% oxidized fat and 100mg/kg Guemengja Extracts (100mg/kg Guemengja Extracts group, Ⅲ) and basal diet, 10% oxidized fat and 200mg/kg Guemengja Extracts (200mg/kg Guemengja Extracts group, Ⅳ). The level of plasma total cholesterol and triglyceride showed a tendency to decrease, whereas the plasma HDL-cholesterol concentration revealed a tendency to increase in guemengja extracts groups. The level of liver total cholesterol showed no significantly different in all treatment groups, however the level of liver triglyceride showed a tendance to decrease in guemengja extracts groups. Thiobarbituric acid(TBARS) values in plasma and liver showed a tendence to decrease in guemengja extracts groups. The guemengja extracts samples have also decreased the plasma GOT and GPT activities, whereas they have increased the liver glutathione peroxidase, superoxide dismutase and catalase activity.

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