Potential of Lilium lancifolium in Alleviating Pain and Inflammation in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
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Lilium lancifolium (LL) is widely cultivated in East Asia and used to attenuate airway diseases. Our current studyaimed to investigate the therapeutic effect of LL on pain level and inflammatory response in a rat model of monosodiumiodoacetate (MIA)-induced osteoarthritis (OA). We first examined the effect of LL on inflammatory cytokines andinflammatory mediators in IL-1β-treated HTB-94 cells. The LL extract was found to significantly inhibit the levels ofInterleukin-6 (IL-6), Interleukin-8 (IL-8), and prostaglandin-E2 (PGE-2) in Interleukin-1 β (IL-1β)-stimulated HTB-94cells in a dose-dependent manner. Moreover, chronic oral administration of LL effectively restored the weight-bearingdistribution in the rat model of MIA-induced OA. In addition, administration of LL inhibited inflammatory cytokines andinflammatory mediators, such as C-reactive protein (CRP), IL-6, leukotriene B4 (LTB-4), PGE-2, and matrixmetalloproteinase-9 (MMP-9). Our findings collectively suggested LL as one of the potential therapeutic agents for OA,owing to its properties of reducing pain and inflammatory responses.
Abstract
Lilium lancifolium (LL) is widely cultivated in East Asia and used to attenuate airway diseases. Our current studyaimed to investigate the therapeutic effect of LL on pain level and inflammatory response in a rat model of monosodiumiodoacetate (MIA)-induced osteoarthritis (OA). We first examined the effect of LL on inflammatory cytokines andinflammatory mediators in IL-1β-treated HTB-94 cells. The LL extract was found to significantly inhibit the levels ofInterleukin-6 (IL-6), Interleukin-8 (IL-8), and prostaglandin-E2 (PGE-2) in Interleukin-1 β (IL-1β)-stimulated HTB-94cells in a dose-dependent manner. Moreover, chronic oral administration of LL effectively restored the weight-bearingdistribution in the rat model of MIA-induced OA. In addition, administration of LL inhibited inflammatory cytokines andinflammatory mediators, such as C-reactive protein (CRP), IL-6, leukotriene B4 (LTB-4), PGE-2, and matrixmetalloproteinase-9 (MMP-9). Our findings collectively suggested LL as one of the potential therapeutic agents for OA,owing to its properties of reducing pain and inflammatory responses.
참고문헌 (22)
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