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Impaired Response Inhibition in Patients with Obsessive-Compulsive Disorder
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Objective : Impaired response inhibition has been suggested to play an important role in the pathophysi- ology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibi- tion in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with com- mission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contrib- ute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in pa- tients with OCD. (Anxiety and Mood 2015;11(1):33-37)
Abstract
Objective : Impaired response inhibition has been suggested to play an important role in the pathophysi- ology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibi- tion in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with com- mission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contrib- ute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in pa- tients with OCD. (Anxiety and Mood 2015;11(1):33-37)
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