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사회불안장애에서 편도 하위영역의 내재 기능적 연결성의 특성

Characteristics of Intrinsic Functional Connectivity of Amygdalar Subregions in Social Anxiety Disorder

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주제분류정신과학

초록

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous func-tionalneuroimagingstudies. Methods : Resting-state functional magnetic resonance imaging data was obtainedin 20 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and subgenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality insuperficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

Abstract

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous func-tionalneuroimagingstudies. Methods : Resting-state functional magnetic resonance imaging data was obtainedin 20 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and subgenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality insuperficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

참고문헌 (50)

  1. American Psychiatric Association, "Diagnostic And Statistical Manual Of Mental Disorders DSM-IV Author", pp.886~ (1994), APA
  2. Furmark T, "Social phobia : overview of community surveys", ActaPsychiatr Scand, 105, pp.84~93 (2002)
  3. Blair K, "Neural response to self-and other referential praise and criticism in generalized social phobia", Arch Gen Psychiatry, 65, pp.1176~1184 (2008)
  4. Blair K, "Response to emotional expressions in generalized social phobia and generalized anxiety disorder : evidence for separate disorders", Am J Psychiatry, 165, pp.1193~1202 (2008)
  5. Blair KS, "The pathology of social phobia is independent of developmental changes in face processing", Am J Psychiatry, 168, pp.1202~1209 (2011)
  6. Damsa C, "Current status of brain imaging in anxiety disorders", Curr Opin Psychiatry, 22, pp.96~110 (2009)
  7. Etkin A, "Functional neuroimaging of anxiety : a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia", Am J Psychiatry, 164, pp.1476~1488 (2007)
  8. Freitas-Ferrari MC, "Neuroimaging in social anxiety disorder : a systematic review of the literature", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.565~580 (2010)
  9. Gentili C, "Beyond amygdala : default mode network activity differs between patients with social phobia and healthy controls", Brain Res Bull, 79, pp.409~413 (2009)
  10. Shah SG, "Amygdala and insula response to emotional images in patients with generalized social anxiety disorder", J Psychiatry Neurosci, 34, pp.296~ (2009)
  11. Amir N, "Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia", Biol Psychiatry, 57, pp.975~981 (2005)
  12. Fox MD, "Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging", Nat Rev Neurosci, 8, pp.700~711 (2007)
  13. Kim MJ, "Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest", Cereb Cortex, 21, pp.1667~1673 (2011)
  14. Hahn A, "Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder", Neuroimage, 56, pp.881~889 (2011)
  15. Liao W, "Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study", PLoS One, 5, pp.e15238~ (2010)
  16. Sladky R., "Disrupted effective connectivity between the amygdala and orbitofrontal cortex in social anxiety disorder during emotion discrimination revealed by dynamic causal modeling for fMRI", Cereb Cortex (2013)
  17. Jacobs RH, "The amygdala, top-down effects, and selective attention to features", Neurosci Biobehav Rev, 36, pp.2069~2084 (2012)
  18. Sah P, "The amygdaloid complex : anatomy and physiology", Physiol Rev, 83, pp.803~834 (2003)
  19. Grijalva CV, "Contrasting effects of centromedial and basolateralamygdaloid lesions on stress-related responses in the rat.Physiol Behav", Physiol Behav, 48, pp.495~500 (1990)
  20. Terburg D, "Hypervigilance for fear after basolateral amygdala da-mage in humans", Transl Psychiatry, 2, pp.e115~ (2012)
  21. Etkin A, "Disrupted amygdalarsubregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder", Arch Gen Psychiatry, 66, pp.1361~1372 (2009)
  22. Li Y, "Sex-dependent correlations between the personality dimension of harm avoidance and the resting-state functional connectivity of amygdala subregions", PLoS One, 7, pp.e35925~ (2012)
  23. Roy AK, "Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder", J Am Acad Child Adolesc Psychiatry, 52, pp.290~299 (2013)
  24. Bzdok D, "An investigation of the structural, connectional, and functional subspecialization in the human amygdala", Hum Brain Mapp, 34, pp.3247~3266 (2013)
  25. Goossens L, "Selective processing of social stimuli in the superficial amygdala", Hum Brain Mapp, 30, pp.3332~3338 (2009)
  26. 허재홍, "자율신경계 신체반응, 인지과정이사회불안에 미치는 영향", 한국심리학회지: 상담 및 심리치료, 17(4), pp.983~1002 (2005), 한국상담심리학회
  27. Macrae CN, "Medial prefrontal activity predicts memory for self", Cereb Cortex, 14, pp.647~654 (2004)
  28. Wagner AD, "Parietal lobe contributions to episodic memory retrieval", Trends Cogn Sci, 9, pp.445~453 (2005)
  29. Cavanna AE, "The precuneus : a review of its functional anatomy and behavioural correlates", Brain, 129, pp.564~583 (2006)
  30. D’Esposito M, "Maintenance versus manipulation of information held in working memory: an event-related fMRI study", Brain Cogn, 41, pp.66~86 (1999)
  31. Veltman DJ, "Maintenance versus manipulation in verbal working memory revisited: an fMRI study", Neuroimage, 18, pp.247~256 (2003)
  32. Koenigs M, "Superior parietal cortex is critical for the manipulation of information in working memory", J Neurosci, 29, pp.14980~14986 (2009)
  33. Cohen JD, "Anterior cingulate and prefrontal cortex : who’s in control?", Nat Neurosci, 3, pp.421~423 (2000)
  34. Fellows LK, "Is anterior cingulate cortex necessary for cognitive control?", Brain, 128, pp.788~796 (2005)
  35. MacDonald AW, "Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control", Science, 288, pp.1835~1838 (2000)
  36. Maddock RJ, "Remembering familiar people : the posterior cingulate cortex and autobiographical memory retrieval", Neuroscience, 104, pp.667~676 (2001)
  37. Ochsner KN, "The cognitive control of emotion", Trends Cogn Sci, 9, pp.242~249 (2005)
  38. Small DM, "Mesulam MM. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention", Neuroimage, 18, pp.633~641 (2003)
  39. First MB, "Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID- CV)", New York State Psychiatric Institute Biometric Research, ~ (1997)
  40. 유은승, "한국판 Liebowitz사회불안척도(LSAS)의 요인구조 및 진단적 유용성 -대학생 집단과 사회공포증환자 집단을 중심으로", Korean Journal of Clinical Psychology, 26(1), pp.251~270 (2007), 한국임상심리학회
  41. Annett MA, "Classification of hand preference by association analysis", Br J Psychol, 61, pp.303~321 (1970)
  42. Gotlib IH, "Subgenual anterior cingulate activation to valenced emotional stimuli in major depression", Neuroreport, 16, pp.1731~1734 (2005)
  43. Goldin PR, "Neural bases of social anxiety disorder : emotional reactivity and cognitive regulation during social and physical threat", Arch Gen Psychiatry, 66, pp.170~180 (2009)
  44. Margulies DS, "Mapping the functional connectivity of anterior cingulate cortex", Neuroimage, 37, pp.579~588 (2007)
  45. Poldrack RA, "Functional specialization for semantic and phonological processing in the left inferior prefrontal cortex", Neuroimage, 10, pp.15~35 (1999)
  46. D’Esposito M, "Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies", Exp Brain Res, 133, pp.3~11 (2000)
  47. Etkin A., "Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces", Neuron, 44, pp.1043~1055 (2004)
  48. Frith CD, "The neural basis of mentalizing", Neuron, 50, pp.531~534 (2006)
  49. Faytout M, "Social phobia, fear of negative evaluation and harm avoidance", Eur Psychiatry, 22, pp.75~79 (2007)
  50. Roy AK, "Functional connectivity of the human amygdala using resting state fMRI", Neuroimage, 45, pp.614~626 (2009)

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