유방암 생존자의 기분장애 발생 위험요인
Risk Factor of Mood Disorder Development in Breast Cancer Survivors
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective : The questionnaire-based study model has a problem in that there is no information on diseases and drugs to determine the association between mood disorders and the severity of comorbid diseases in cancer survivors. This study used claim data collected by the National Health Insurance Corporation over nine years to identify risk factors of mood disorders in breast cancer survivors Methods : 2,065 patients were included in this study, excluding someone who were diagnosed mood disorders one year before breast cancer diagnosis. All statistical analysis was performed with R4.0.0 Chi-Square test and Cox’s proportional hazards model was performed. Results : Chi-square test was performed to confirm the general characteristics of the subjects. There were 461 (22.32%) patients with mood disorders and 1,604 (77.67%) patients with no mood disorders. In the univariate Model 1 according to the CCI, the HR in the case of CCI 2 was analyzed as 1.629(95% CI, 1.15-2.30), CCI≥3 was analyzed as 2.031(95% CI 1.48-2.78), compared to the study subjects with CCI=0. The age and survivorship adjusted Model 2 HR, CCI=2 was 1.615(95% CI, 1.14-2.28), CCI≥3 was analyzed as 1.924 (95% CI 1.40-2.65). The fully adjusted Model 3 HR, CCI=2 was 1.599 (95% CI, 1.12-2.28), CCI≥3 was analyzed as 1.760 (95% CI 1.25-2.49). Conclusion : In order to improve the long-term quality of life for breast cancer survivors in the future, it is necessary to manage survivorship, the severity of comorbidities, which are identified as risk factors for the development of mood disorders.
Abstract
Objective : The questionnaire-based study model has a problem in that there is no information on diseases and drugs to determine the association between mood disorders and the severity of comorbid diseases in cancer survivors. This study used claim data collected by the National Health Insurance Corporation over nine years to identify risk factors of mood disorders in breast cancer survivors Methods : 2,065 patients were included in this study, excluding someone who were diagnosed mood disorders one year before breast cancer diagnosis. All statistical analysis was performed with R4.0.0 Chi-Square test and Cox’s proportional hazards model was performed. Results : Chi-square test was performed to confirm the general characteristics of the subjects. There were 461 (22.32%) patients with mood disorders and 1,604 (77.67%) patients with no mood disorders. In the univariate Model 1 according to the CCI, the HR in the case of CCI 2 was analyzed as 1.629(95% CI, 1.15-2.30), CCI≥3 was analyzed as 2.031(95% CI 1.48-2.78), compared to the study subjects with CCI=0. The age and survivorship adjusted Model 2 HR, CCI=2 was 1.615(95% CI, 1.14-2.28), CCI≥3 was analyzed as 1.924 (95% CI 1.40-2.65). The fully adjusted Model 3 HR, CCI=2 was 1.599 (95% CI, 1.12-2.28), CCI≥3 was analyzed as 1.760 (95% CI 1.25-2.49). Conclusion : In order to improve the long-term quality of life for breast cancer survivors in the future, it is necessary to manage survivorship, the severity of comorbidities, which are identified as risk factors for the development of mood disorders.
참고문헌 (28)
- Annual re-port of cancer statistics in Korea in 2017, "Korea Central Cancer Registry", Ministry of Health and Wel-fare, ~ (2017)
- Ng HS, "Comor-bidities in Australian women with hormone-dependeant breast can-cer : a populaion-based analysis", Med J Aust, 208, pp.24~28 (2018)
- Lee JE, "The current status of cancer survivorship care and a consideration of appropriate care model in Korea", Korean Journal of Clinical Oncology, 10, pp.58~62 (2014)
- 박진희, "일차 치료종료 후 유방암환자의 디스트레스와 영향요인", Asian Oncology Nursing, 15(3), pp.132~139 (2015), 대한종양간호학회
- Hegel MT, "Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer", Cancer, 107, pp.2924~2931 (2006)
- Mehnert A, "Four-week prevalence of mental disorders in patients with cancer across major tumor entities", J Clin Oncol, 32, pp.3540~3546 (2014)
- Zhang C, "Depression in-duced by total mastectomy, breast conserving surgery and breast re-construction : a systematic review and meta-analysis", World J Surg, 42, pp.2076~2085 (2018)
- Suppli NP, "Increased risk for depression after breast cancer : a nation-wide population-based cohort study of associated factors in Denmark, 1998-2011", J Clin Oncol, 32, pp.3831~3839 (2014)
- Khan S, "Levels of depression and anxiety post-mastectomy in breast cancer patients at a Public Sector Hospital in Karachi", Asian Pac J Cancer Prev, 17, pp.1337~1340 (2016)
- Khan NF, "Consulting and prescrib-ing behaviour for anxiety and depression in long-term survivors of cancer in the UK", Eur J Cancer, 46, pp.3339~3344 (2010)
- Ng HS, "Comor-bidities in Australian women with hormone-dependeant breast can-cer : a populaion-based analysis", Med J Aust, 208, pp.24~28 (2018)
- 정수연, "국내 우울증 평가도구 타당화 연구의 체계적 고찰-진단적 타당성을 중점으로 : 한국형 우울 선별 도구 개발을 위한 예비 연구", 대한불안의학회지, 13(2), pp.53~59 (2017), 대한불안의학회[DOI]
- Maass SWMC, "The prevalence of long-term symptoms of depression and anxi-ety after breast cancer treatment : a systematic review", Maturitas, 82, pp.100~108 (2015)
- Suppli NP, "Increased risk for depression after breast cancer : a nation-wide population-based cohort study of associated factors in Den-mark, 1998-2011. Increased risk for depression after breast cancer : a nationwide population-based cohort study of associated factors in Denmark, 1998-2011", J Clin Oncol, 32, pp.3831~3839 (2014)
- Yang H, "Time-dependent risk of depression, anxiety, and stress-related dis-orders in patients with invasive and in situ breast cancer", Int J Can-cer, 140, pp.841~852 (2017)
- Hung YP, "In-cidence and risk of mood disorders in patients with breast cancers in Taiwan : a nationwide population-based study", Psycho-Oncology, 22, pp.2227~2234 (2013)
- 서화정, "Care Pathway for Cancer Survivorship in Korea: Trend of Breast Cancer Pathway from 2003 to 2010", Healthcare Informatics Research, 23(2), pp.119~125 (2017), 대한의료정보학회[DOI]
- Hwangbo Y, "In-cidence of diabetes after cancer development : a Korean national co-hort study", JAMA Oncol, 4, pp.1099~1105 (2018)
- Heo JS, "Psychiatric comorbidi-ties among breast cancer survivors in South Korea : a nationwide pop-ulation-based study", Breast Cancer Res Treat, 162, pp.151~158 (2017)
- Lu D, "Clinical diagnosis of mental disorders immediately before and after cancer diagnosis : a nationwide matched cohort study in Sweden", JAMA Oncol, 2, pp.1188~1196 (2016)
- Quan H, "Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data", Med Care, 43, pp.1130~1139 (2005)
- Townsend L, "A systematic review of validated methods for identifying depression using administra-tive data", Pharmacoepidemiol Drug Saf, 21(Suppl 1), pp.163~173 (2012)
- Hu LY, "Depressive disorders among patients with gastric cancer in Taiwan : a nationwide population-based study", BMC Psychiatry, 18, pp.272~ (2018)
- 박보람, "The Prevalence of Depression among Patients with the Top Ten Most Common Cancers in South Korea", PSYCHIATRY INVESTIGATION, 14(5), pp.618~625 (2017), 대한신경정신의학회[DOI]
- Goldzweig G, "Is age a risk factor for depression among the oldest old with can-cer?", J Geriatr Oncol, 9, pp.476~481 (2018)
- Hung YP, "In-cidence and risk of mood disorders in patients with breast cancers in Taiwan : a nationwide population-based study", Psychooncology, 22, pp.2227~2234 (2013)
- Schneider CM, "Cancer treatment-induced alterations in muscular fitness and quality of life : the role of exercise training", Ann Oncol, 18, pp.1957~1962 (2007)
- Adamsen L, "Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial", BMJ, 339, pp.b3410~ (2009)