추적관찰을 통해 살펴본 한증 HRV지표
Heart Rate Variability in Cold Pattern: 3-year Follow-up Study
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
This study aimed to investigate heart rate variability (HRV) characteristics of cold pattern with repeated measurement data. Participants were taken from a Daejeon University cohort study from 2015 to 2018. Forty-seven of the participants studied displayed cold pattern while 23 showed signs of non-cold pattern. HRV was measured in supine position for 5 minutes at each year, and an 8-item cold pattern questionnaire was used for the diagnosis of cold pattern. SDNN (standard deviation of the NN intervals) and RMSSD (the square root of the mean squared differences of successive NN intervals) were used as time domain analysis, and TP (total power), VLF (power in very low frequency range), LF (power in low frequency range), HF (power in high frequency range), LF norm (LF power in normalized units), HF norm (HF power in normalized units) and LF/HF were used as frequency domain analysis. In the Mann-Whitney U test, LF norm, HF norm, and LF/HF showed differences between the cold pattern group and non-cold pattern group at every measurement, and in the independent t-test, the differences were also observed at three points except for the baseline (2015). In the repeated measures ANOVA, the interaction effects were not observed in all HRV parameters, but the time period effects were observed in SDNN, RMSSD, TP, VLF, LF and HF. There were significant differences between those two groups in LF norm, HF norm and LF/HF. This study suggests that LF norm, HF norm and LF/HF might be a useful indicator of cold pattern properties.
Abstract
This study aimed to investigate heart rate variability (HRV) characteristics of cold pattern with repeated measurement data. Participants were taken from a Daejeon University cohort study from 2015 to 2018. Forty-seven of the participants studied displayed cold pattern while 23 showed signs of non-cold pattern. HRV was measured in supine position for 5 minutes at each year, and an 8-item cold pattern questionnaire was used for the diagnosis of cold pattern. SDNN (standard deviation of the NN intervals) and RMSSD (the square root of the mean squared differences of successive NN intervals) were used as time domain analysis, and TP (total power), VLF (power in very low frequency range), LF (power in low frequency range), HF (power in high frequency range), LF norm (LF power in normalized units), HF norm (HF power in normalized units) and LF/HF were used as frequency domain analysis. In the Mann-Whitney U test, LF norm, HF norm, and LF/HF showed differences between the cold pattern group and non-cold pattern group at every measurement, and in the independent t-test, the differences were also observed at three points except for the baseline (2015). In the repeated measures ANOVA, the interaction effects were not observed in all HRV parameters, but the time period effects were observed in SDNN, RMSSD, TP, VLF, LF and HF. There were significant differences between those two groups in LF norm, HF norm and LF/HF. This study suggests that LF norm, HF norm and LF/HF might be a useful indicator of cold pattern properties.
참고문헌 (45)
- Ferreira AS, "Chinese medicine pattern differentiation and its implications for clinical practice", Chin J Integr Med, 17, pp.818~823 (2011)
- World Health Organization, "WHO international standard terminologies on traditional medicine in the western pacific region", World Health Organization, ~ (2007)
- 여민경, "한열변증의 국내 임상연구 동향 분석 – 일반인의 정량지표를 중심으로", 동의생리병리학회지, 31(2), pp.145~152 (2017), 한의병리학회[DOI]
- 배광호, "Perception of cold and heat pattern identification in diseases: a survey of Korean medicine doctors", Integrative Medicine Research, 6(1), pp.26~32 (2017), 한국한의학연구원[DOI]
- 배광호, "평소 증상 기반 한열변증 설문지의 신뢰도 및 타당도 연구", 동의생리병리학회지, 32(5), pp.341~346 (2018), 한의병리학회[DOI]
- Park YJ, "A Study on the Diagnostic Elements of Cold-Heat Pattern Identification by Korean Medicine Doctors: Association with Objective and Subjective Body Temperature", Evid Based Complement Alternat Med, pp.7593056~ (2017)
- Mun S, "Cold and Spleen-Qi Deficiency Patterns in Korean Medicine Are Associated with Low Resting Metabolic Rate", Evid Based Complement Alternat Med, 2017, pp.9532073~ (2017)
- Nagashima K, "Thermal regulation and comfort during a mild-cold exposure in young Japanese women complaining of unusual coldness", J Appl Physiol, 92, pp.1029~1035 (2002)
- Park YJ, "Relationships between oriental medical pattern diagnosis and cardiovascular autonomic function", Eur J Integr Med, 5, pp.506~513 (2013)
- 김수정, "건강군과 미병군의 한열지표 차이에 관한 연구", 대한예방한의학회지, 21(1), pp.49~56 (2017), 대한예방한의학회[DOI]
- Bae KH, "Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia : Results of a Multicenter Survey Study", Evid Based Complement Alternat Med, 2016, pp.8948690~ (2016)
- Bae KH, "The association between cold hypersensitivity in the hands and feet and chronic disease : results of a multicentre study", BMC Complement Altern Med, 18, pp.40~ (2018)
- Yoshino T, "Statistical analysis of hie(cold sensation)and hiesho(cold disorder)in kampo clinic", Evid Based Complement Alternat Med, 2013, pp.398458~ (2013)
- Bubnov R, ""Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question", EPMA J, 8, pp.141~157 (2017)
- Mowery NT, "Core temperature variation is associated with heart rate variability independent of cardiac index : a study of 278 trauma patients", J Crit Care, 26, pp.534.e9~534.e17 (2011)
- Almeida AC, "The effects of cold water immersion with different dosages(duration and temperature variations)on heart rate variability post-exercise recovery : A randomized controlled trial", J Sci Med Sport, 19, pp.676~681 (2016)
- Massaro AN, "Effect of Temperature on Heart Rate Variability in Neonatal ICU Patients With Hypoxic-Ischemic Encephalopathy", Pediatr Crit Care Med, 18, pp.349~354 (2017)
- 김상호, "한의학 임상연구에서의 심박변이도 검사 활용현황과 측정조건에 대한 고찰", Journal of Acupuncture Research, 29(5), pp.127~137 (2012), 대한침구의학회
- Kong XL, "Relationship between Heart Rate Variability and Cold–heat", Deficiency-excess Syndromes in TCM, 2010, pp.51, 348~351
- 박종주, "만성변비환자의 한열변증에 따른 심박변이도에 관한 연구", 대한한방내과학회지, 33(2), pp.209~221 (2012), 대한한방내과학회
- 김지은, "건강인의 표리 한열 변증, HRV, 우울, 불안 지표의 상관성 분석", 동의생리병리학회지, 20(2), pp.482~487 (2006), 한의병리학회
- 이성헌, "다한증 환자의 한의학적 변증특성 및 자율신경계 기능과의 상관관계", 대한한방내과학회지, 29(2), pp.359~374 (2008), 대한한방내과학회
- Task Force of The European Society of Cardiology, "Heart rate variability-Standards of measurement, physiological interpretation, and clinical use", Eur Heart J., 17, pp.354~381 (1996)
- Hon EH, "ELECTRONIC EVALUATION OF THE FETAL HEART RATE. VIII. PATTERNS PRECEDING FETAL DEATH, FURTHER OBSERVATIONS", Am J Obstet Gynecol, 87, pp.814~826 (1963)
- Ewing DJ, "The value of cardiovascular autonomic function tests : 10 years experience in diabetes", Diabetes Care, 8, pp.491~498 (1985)
- Bigger JT, Jr., "Frequency domain measures of heart period variability and mortality after myocardial infarction", Circulation, 85, pp.164~171 (1992)
- 채윤병, "침과 자율신경계 고찰: 인체의 심박변이도 중심으로", Korean Journal of Acupuncture, 24(4), pp.25~36 (2007), 경락경혈학회
- 육태한, "Sweet Bee Venom과 Bee Venom이 심박변이도(HRV)에 미치는 영향", Journal of Pharmacopuncture, 11(1), pp.41~54 (2008), 대한약침학회
- 양창섭, "마황복용이 정상성인의 체중 감소와 심박변이도에 미치는 영향에 관한 예비 연구: 무작위배정 이중맹검시험", 대한한방내과학회지, 27(4), pp.836~844 (2006), 대한한방내과학회
- 이정환, "자율신경균형검사와 사상체질과의 상관성에 관한 연구", 사상체질의학회지, 19(3), pp.176~187 (2007), 사상체질의학회
- Park YJ, "A Study on Correlation between Bian Zheng with Autonomic functions", The Journal of the Society of Korean Medicine Diagnostics, 6, pp.123~134 (2002)
- 배장한, "냉자극에 대한 맥율 변화 예비 연구", 동의생리병리학회지, 28(6), pp.668~673 (2014), 한의병리학회[DOI]
- 배광호, "건강 증진을 위한 평소 증상 기반의 한열변증 설문지 개발 - 일치도를 중심으로", 대한예방한의학회지, 20(2), pp.17~26 (2016), 대한예방한의학회
- Tegegne BS, "Determinants of heart rate variability in the general population : The Lifelines Cohort Study", Heart rhythm, 15, pp.1552~1558 (2018)
- Bae KH, "The Relationship between Cold Hypersensitivity in the Hands and Feet and Health-Related Quality of Life in Koreans : A Nationwide Population Survey", Evid Based Complement Alternat Med, 2019, pp.10~ (2019)
- Shaffer F, "An Overview of Heart Rate Variability Metrics and Norms", Front Public Health, 5, pp.258~ (2017)
- DeGiorgio CM, "RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP : the SUDEP-7 Inventory", Epilepsy Behav, 19, pp.78~81 (2010)
- Shaffer F, "A healthy heart is not a metronome : an integrative review of the heart's anatomy and heart rate variability", Front Psychol, 5, pp.1040~ (2014)
- Hadase M, "Very low frequency power of heart rate variability is a powerful predictor of clinical prognosis in patients with congestive heart failure", Circ J, 68, pp.343~347 (2004)
- Kuusela T, "Heart rate variability (HRV) signal analysis", pp.9~42 (2013), CRC Press
- Mccraty R, "Heart rate variability : new perspectives on physiological mechanisms, assessment of self-regulatory capacity, and health risk", Glob Adv Health Med, 4, pp.46~61 (2015)
- Kim SK Im JJ, "The effect of Han-Yeol Attribute on the Mechanocardiogram", The Journal of the Society of Korean Medicine Diagnostics, 8, pp.135~153 (2004)
- Park SB, "Standardized tests of heart rate variability for autonomic function tests in healthy Koreans", Int J Neurosci, 117, pp.1707~1717 (2007)
- Koichubekov BK, "Nonlinear analyses of heart rate variability in hypertension", Ann Cardiol Angeiol, 67, pp.174~179 (2018)
- Kangas P, "Metabolic syndrome is associated with decreased heart rate variability in a sex-dependent manner : a comparison between 252 men and 249 women", Clin Physiol Funct Imaging, 39, pp.160~167 (2019)