과민성 대장증후군 환자를 대상으로 수행된 한약 및 침구치료의 객관적 효과와 기전 연구에 대한 문헌고찰
Review on the Objective Effect and Mechanism Studies of Herbal Medicine, Acupuncture and Moxibustion Treatment for Irritable Bowel Syndrome Patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The purpose of this study was to explore objective indicators(outcomes) which are used to evaluate clinical efficacy and figure out the mechanisms of herbal medicine, acupuncture and moxibustion treatment for Irritable bowel syndrome(IBS). We searched randomized controlled trials(RCTs) that mediated with herbal medicine, acupuncture and moxibustion treatment for IBS and used objective indicators for outcome from November 1, 2020 to December 31, 2020. The RCTs that were published in Korean, English and Chinese were included in this study. The selected literatures were analyzed about methods of result measurement and assessed by Cochrane’s risk of bias(RoB). Total 18 RCTs were included in this study. There were lots of objective indicators for result measurement; the concentration of hormones in blood and neurotransmitters, the sensitivity of rectum, the functional assessment of central nerve and autonomic nerve system, the change of intestinal flora, the concentration of serum cytokines. Various objective indicators can be used to evaluate the clinical efficacy of with herbal medicine, acupuncture and moxibustion treatment for IBS, but due to the limitations of the quality of the included studies, systematic review and meta-analysis will be needed.
Abstract
The purpose of this study was to explore objective indicators(outcomes) which are used to evaluate clinical efficacy and figure out the mechanisms of herbal medicine, acupuncture and moxibustion treatment for Irritable bowel syndrome(IBS). We searched randomized controlled trials(RCTs) that mediated with herbal medicine, acupuncture and moxibustion treatment for IBS and used objective indicators for outcome from November 1, 2020 to December 31, 2020. The RCTs that were published in Korean, English and Chinese were included in this study. The selected literatures were analyzed about methods of result measurement and assessed by Cochrane’s risk of bias(RoB). Total 18 RCTs were included in this study. There were lots of objective indicators for result measurement; the concentration of hormones in blood and neurotransmitters, the sensitivity of rectum, the functional assessment of central nerve and autonomic nerve system, the change of intestinal flora, the concentration of serum cytokines. Various objective indicators can be used to evaluate the clinical efficacy of with herbal medicine, acupuncture and moxibustion treatment for IBS, but due to the limitations of the quality of the included studies, systematic review and meta-analysis will be needed.
참고문헌 (52)
- 장석주, "PubMed로 검색한 과민성장증후군의 침치료에 관한 문헌 고찰", 대한한방소아과학회지, 32(3), pp.119~130 (2018), 대한한방소아과학회[DOI]
- 한창우, "내장감각과민의 침구 치료에 대한 실험연구 현황: PubMed를 중심으로", Korean Journal of Acupuncture, 36(2), pp.93~103 (2019), 경락경혈학회[DOI]
- Foxx-Orenstein A, "IBS–review and what's new", Medscape General Medicine, 8(3), pp.20~ (2006)
- Meizhe P, "The Clinical and Experimental Study on Soothing Liver and Trengthening Spleen Intervention of Diarrhea-predominant Irritable Bowel Syndrome", World Traditional Chinese Medicine, 9(12), pp.1595~1598 (2014)
- Andres Acosta, "A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome", Journal of Neurogastroenterology and Motility (JNM), 22(1), pp.69~77 (2016), 대한소화기 기능성질환∙운동학회[DOI]
- 김현설, "위장관 질환의 치료를 위한 한의학 연구 동향", 동의생리병리학회지, 27(5), pp.570~577 (2013), 한의병리학회
- Jones M, "A biomarker panel and psychological morbidity differentiates the irritable bowel syndrome from health and provides novel pathophysiological leads", Alimentary pharmacology & therapeutics, 39(4), pp.426~437 (2014)
- Lembo A, "Use of serum biomarkers in a diagnostic test for irritable bowel syndrome", Alimentary pharmacology & therapeutics, 29(8), pp.834~842 (2009)
- Dae-Seog H, "NECA's guidance for undertaking systematic reviews and meta-analyses for intervention", research report, 1(1), pp.1~287 (2015)
- "2014", 34(2)
- "2015", 34(1)
- Cong L, "Clinical Observation on Acupuncture Combined with Thunder-Fire Moxibustion in Treating IBS of Spleen-Deficiency Diarrhea", Journal of Chinese Medicine, 48(03), pp.56~60 (2020)
- Liu-xiang H, "Effects of Tongxie Anpi Decoction Combined with Trimebutine Maleate Tablets on Serum 5-HT and CGRP in Patients with Diarrhea-predominant Irritable Bowel Syndrome with Hepatic Stagnation and Splenic Deficiency", Chinese Journal of Experimental Formulas, 22(05), pp.188~191 (2016)
- "2020", 40(6)
- Chen-er Z, "A Clinical Study on Banxia Xiexin Decoction Treating Diarrhea Predominated Irritable Bowel Syndrome by Observing the Expression of Ghrelin", Chinese Journal of Traditional Chinese Medicine, 29(11), pp.2588~2591 (2011)
- Zhao J, "Electroacupuncture inhibits the activity of astrocytes in spinal cord in rats with visceral hypersensitivity by inhibiting P2Y1 receptor-mediated MAPK", ERK signaling pathway, 2020, pp.2020, ~
- Lowe C, "Sham acupuncture is as efficacious as true acupuncture for the treatment of IBS: A randomized placebo controlled trial", Neurogastroenterology and Motility, 29(7) (2017)
- Su-ping Y, "Effect of modified Sinisan on anorectal manometry of the constipation predominant type of irritable bowel syndrome", Chinese journal of integrative medicine, 11(1), pp.27~30 (2005)
- Gao W, "Effect of jianpi tiaogan wenshen recipe in treating diarrhea-predominant irritable bowel syndrome", Zhongxiyi jiehe zazhi= Chinese journal of integrated traditional and Western medicine, 30(1), pp.13~17 (2010)
- Shen J, "Effect of changji'an oral liquid on activated signal alterative intensity in algesthesia domain in patients with diarrhea type irritable bowel syndrome due to gan-pi disharmony", Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi= Chinese journal of integrated traditional and Western medicine, 25(11), pp.967~970 (2005)
- Winnie CW Chu, "Does Acupuncture Therapy Alter Activation of Neural Pathway for Pain Perception in Irritable Bowel Syndrome?: A Comparative Study of True and Sham Acupuncture Using Functional Magnetic Resonance Imaging", Journal of Neurogastroenterology and Motility (JNM), 18(3), pp.305~316 (2012), 대한소화기 기능성질환∙운동학회[DOI]
- Schneider A, "Neuroendocrinological effects of acupuncture treatment in patients with irritable bowel syndrome", Complementary therapies in medicine, 15(4), pp.255~263 (2007)
- Xing-xing Z, "Efficacy of Jianpi Shugan Fomula on Intestinal Flora of Patients with Diarrhea Predominant Irritable Bowel Syndrome and Its Effect on Intestinal Flora", Chinese Journal of Experimental Formulas, 25(13), pp.79~86 (2019)
- Sun X, "Observation on intestinal flora in patients of irritable bowel syndrome after treatment of Chinese integrative medicine", Zhong xi yi jie he xue bao= Journal of Chinese integrative medicine, 2(5), pp.340~342 (2004)
- "2013", 33(12)
- Runhong Z, "The effect of accupuncture-moxibustion treatment on serum IL-18, IL-23 and TNF-α level of elderly people with IBS", Chinese Journal of Gerontology, 33(06), pp.1435~1436 (2013)
- Sood R, "Diagnosis of IBS : symptoms, symptom-based criteria, biomarkers or'psychomarkers'", Nature Reviews Gastroenterology & Hepatology, 11(11), pp.683~ (2014)
- Aziz I, "How the change in IBS criteria from Rome III to Rome IV impacts on clinical characteristics and key pathophysiological factors", American Journal of Gastroenterology, 113(7), pp.1017~1025 (2018)
- W Wilson D, "Role of hormones and neuropeptides in IBS and other gastrointestinal disorders: understanding variability and chrononutrition", The Open Nutraceuticals Journal, 4(1) (2011)
- Dunlop SP, "Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome", Clinical Gastroenterology and Hepatology, 3(4), pp.349~357 (2005)
- Atkinson W, "Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome", Gastroenterology, 130(1), pp.34~43 (2006)
- Bearcroft C, "Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome : a pilot study", Gut, 42(1), pp.42~46 (1998)
- Houghton L, "Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome", Gut, 52(5), pp.663~670 (2003)
- Krejs GJ, "Effect of VIP infusion on water and ion transport in the human jejunum", Gastroenterology, 78(4), pp.722~727 (1980)
- Love J, "The electrophysiological effects of vasoactive intestinal polypeptide in the guinea-pig inferior mesenteric ganglion", The Journal of physiology, 394(1), pp.67~84 (1987)
- Palsson OS, "Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome", Digestive diseases and sciences, 49(7), pp.1236~1243 (2004)
- Zhang H, "Correlation of gut hormones with irritable bowel syndrome", Digestion, 78, pp.72~76 (2008)
- Simrén M, "Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome", European journal of gastroenterology & hepatology, 15(1), pp.55~62 (2003)
- Sohn W, "Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea", Scandinavian journal of gastroenterology, 49(1), pp.43~51 (2013)
- "F1000Research", 2019, ~
- Sohn W, "Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea", Scand J Gastroenterol, 49(1), pp.43~51 (2014)
- Qin G, "Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome : Associations with abdominal pain, visceral hypersensitivity and psychological performance", World J Clin Cases, 8(9), pp.1632~1641 (2020)
- El-Salhy M, "Ghrelin in patients with irritable bowel syndrome", International journal of molecular medicine, 23(6), pp.703~707 (2009)
- YT P, "Anorectal funtion test", Korean Journal of Neurogastroenterology and Motility, 5(2) (1999)
- Yuan Y-Z, "Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRI", World journal of gastroenterology : WJG, 9(6), pp.1356~ (2003)
- Lee KN, "Intestinal microbiota in pathophysiology and management of irritable bowel syndrome" (2014)
- Si J-M, "Intestinal microecology and quality of life in irritable bowel syndrome patients", World journal of gastroenterology : WJG, 10(12), pp.1802~ (2004)
- Malinen E, "Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR", American Journal of Gastroenterology, 100(2), pp.373~382 (2005)
- Kerckhoffs APM, "Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients" (2009)
- Bashashati M, "Cytokine imbalance in irritable bowel syndrome : a systematic review and meta-analysis", Neurogastroenterology & Motility, 26(7), pp.1036~1048 (2014)
- Yanqing L, "Study on the shifting of Th1", Th2 balance of large intestinal mucosa in patients with irritable bowel syndrome, 2001, pp.(12), ~
