본문 바로가기
KERD
논문KCI 등재

전립선 암세포에서 敗醬 추출물의 세포고사 유도 효과

Apoptosis-inducing Effect of Herba Patriniae Extract in the Prostate Cancer LNCaP Cells

0

조회

0

다운로드

2

인용

0

참고문헌

주제분류한의학

초록

Abstract

Herba Patriniae(HP) has been known to exert anti-inflammation and -tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that HP extract induced apoptosis in androgen-dependent prostate cancer LNCaP cells as evidenced by DNA fragmentation. Our data demonstrated that HP extract-induced apoptotic cell death was accompanied by inhibition of NF-κB activation, lowering effects of intracellular prostate specific antigen(PSA) and androgen receptor(AR) expression in a time dependent manner. Taken together, HP extract may inhibit the proliferation of prostate cancer LNCaP cell associated with inhibition of NF-κB activation, PSA and AR expression and that of apoptosis.

참고문헌 (25)

  1. "漢英常用中藥手冊", pp.525~526 (2000), 廣東科技出版社
  2. "Cancer statistics, 2001", 51(1), pp.15~36
  3. "Androgen regulation of programmed death of normal and malignant prostatic cells", pp.457~64 (1992)
  4. "NF-kappa B activates prostate- specific antigen expression and is upregulated in androgen-independent prostate cancer", 22(8) (2002)
  5. "Effects of fenretinide (4-HPR) on prostate LNCaP cell growth, apoptosis, and prostate- specific gene expression", 33(2), pp.97~104 (1997)
  6. "review of studies and update of previous survey results", 4(3), pp.289~293 (2000)
  7. "Cell growth and gene modulatory activities of Yunzhi from mushroom Trametes versicolor in androgen-dependent and androgen- insensitive human prostate cancer cells", 18(1) (2001)
  8. "control of oncogenesis and cancer therapy resistance", 1470(2) (2000)
  9. "Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen", 18(51) (1999)
  10. "Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis", 20(31) (2001)
  11. "Novel therapeutic strategies to selectively kill cancer cells", 55, pp.247~252 (1998)
  12. "and response to anti-cancer drugs", pp.3~9 (1994)
  13. "manipulation of cell death the development of novel strategies for the treatment of gastrointestinal disease", 9, pp.215~226 (1995)
  14. "Chloroquine inhibits processing of tumor necrosis factor in lipopolysaccharide-stimulated RAW 264", 158, pp.4901~4907 (1997)
  15. "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding", pp.248~254 (1976)
  16. "Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells", 276(50) (2001)
  17. "Induction of apoptosis by takrisodokyeum through generation of hydrogen peroxide and activation of caspase-3 in HL-60 cells", 73(15) (2003)
  18. "Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis", 63(14) (2003)
  19. "Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells", 20(4) (2002)
  20. "Down-regulation of prostate-specific antigen expression by finasteride through inhibition of complex formation between androgen receptor and steroid receptor-binding consensus in the promoter of the PSA gene in LNCaP cells", 57(4) (1997)
  21. "Inhibition of proliferation and expression of AR", PSA by herbal supplement Equiguard in LNCaP cells cultured in androgen-proficient FBS and androgen-deficient charcoal-stripped FBS is correlated with increased serine-15 phosphorylation of the tumor suppressor gene p53, 2003, pp.23, ~
  22. "Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice", 9(22) (1995)
  23. "Function and activation of NF-κB in the immune system Annual Review of Immunology 12", pp.141~179 (1994)
  24. "The NF-κB and IκB proteins : new discoveries and insights", 14, pp.649~683 (1996)
  25. "The NF-κB and IκB proteins : new discoveries and insights", 14, pp.649~683 (1996)

관련 논문AI추천

이 간행물의 다른 논문 (19건)