전립선 암세포에서 敗醬 추출물의 세포고사 유도 효과
Apoptosis-inducing Effect of Herba Patriniae Extract in the Prostate Cancer LNCaP Cells
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Abstract
Herba Patriniae(HP) has been known to exert anti-inflammation and -tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that HP extract induced apoptosis in androgen-dependent prostate cancer LNCaP cells as evidenced by DNA fragmentation. Our data demonstrated that HP extract-induced apoptotic cell death was accompanied by inhibition of NF-κB activation, lowering effects of intracellular prostate specific antigen(PSA) and androgen receptor(AR) expression in a time dependent manner. Taken together, HP extract may inhibit the proliferation of prostate cancer LNCaP cell associated with inhibition of NF-κB activation, PSA and AR expression and that of apoptosis.
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