대표적 보기약인 인삼, 당삼, 황기, 백출, 산약 물추출액의 면역조절효과 비교
Comparison of Immunomodualtory Effects of Water-extracted Ginseng Radix, Pilose Asia-bell, Astragali Radix, Astractylodes Rhizoma alba and Dioscoreae Rhizoma
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참고문헌
초록
Abstract
This study was carried out to investigate the comparison of immunomodualtory effects of water-extracted Ginseng Radix(GR), Pilose Asia-bell(PA), Astragali Radix(AR), Astractylodes Rhizoma alba(AA) and Dioscoreae Rhizoma (DR). The parameter examined to assess apparent immunomodulatory effect of the water-extracted GR, PA, AR, AA and DR included the regulation of Nitric oxide (NO), the expression of Th1/Th2 type cytokine, the change of B cell phenotype. The water-extracted GR, PA, AR, AA and DR inhibited NO production and iNOS protein expression in LPS stimulated RAW 264.7 macrophage cells. In the Th1 and Th2 cytokine expression, the water-extracted GR, PA, AR, AA and DR induced IL-2 and IFNr mRNA gene expression. Therefore, it seems that the water-extracted GR, PA, AR, AA and DR have a inducing effect of Th1 type cytokines. In the Flow cytometry analysis, the water-extracted GR, PA, AR, AA and DR did not change B cell phenotype (CD45R/B220). The water-extracted GR, PA, AR, AA and DR have a reducing effect of immune suppression cause by Methotrexate (MTX), an agent of immune suppression. These results suggest that the immunomodulatory effects of the water-extracted GR, PA, AR, AA and DR may be, in part, associated with the inducing IL-2 and IFNr mRNA gene expression in and regulation of NO production in macrophage cells.
참고문헌 (21)
- "면역과 한방" (1994)
- "항암 면역 증강 작용이 있는 인삼 다당체에 의한 cytokine mRNA의 발현", pp.324~330 (1998)
- "상황버섯 추출물이 정상 마우스와 cyclophosphamide 로 처리된 마우스의 체액성 면역기능에 미치는 영향"
- "황기(黃耆)의 간기능 보호 성분", pp.111~116 (1996)
- "당귀 추출물이 면역계에 미치는 영향", pp.113~118 (1990)
- "어성초 및 상국음이 면역기능에 미치는 영향", pp.295~318 (1995)
- "IL-6 mRNA Expression in Mouse Peritoneal Macrophages and NIH3T3 Fibroblasts in Response to Candida albicans", pp.8~15 (2000)
- "augments the production of granulocyte-macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro", int j immu(pharmacol), pp.595~598 (1991)
- "신수혈의 침자극과 황기약침이 실험용 생쥐의 면역활성물질인 cytokine의 IL-6 발현에 미치는 영향", pp.147~155 (1998)
- "황기가 면역세포의 기능에 미치는 영향", pp.115~128 (1998)
- "공진난 약침자극이 혈액 및 각 면역 조직의 임파구와 CD4+ T세포에 미치는 영향", pp.179~202 (1999)
- "산화질소(Nitric Oxide) 이로운가? 해로운가? : 산화질소의 화학과 응용", pp.52~63 (1999)
- "Inhibitory effect of ethyl acetate fraction from Cudrania tricuspidata on the expression of nitric oxide synthase gene in RAW 264 7 macrophages stimulated with interferon-and lipopolysaccharide", pp.21~28 (2000)
- "Camptothecin suppresses nitric oxide biosynthesis in RAW 264", pp.7 625~635 (2001)
- "Polygonum tinctorium extract suppresses nitric oxide production by activated macrophages through inhibiting inducible nitric oxide synthase expression", koh j eth(k pharmacol 72), pp.141~150 (2000)
- "Suppression of inducible nitric oxide synthase expression in RAW 264 7 macrophages by two-carboline alkaloids extracted from Melia azedarach", pp.301~309 (2000)
- "The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264", j eth(pharmacol 76), pp.7 119~123 (2001)
- "이 Methotrexate 를 투여한 생쥐의 면역반응에 미치는 영향", pp.49~66 (1994)
- "하수오가 methotrexate로 유도된 흰쥐의 면역기능저하에 미치는 영향", pp.152~169 (2000)
- "사군자탕 및 사물탕이 methotrexate로 유발된 흰쥐의 면역기능저하에 미치는 영향" (1996)
- "Immunomodulatory effects of aqueous-extracted Astragali radix in methotrexate-treated mouse spleen cells", j eth(pharmacol 84)