加味馬錢五子丸 추출물이 雄性 白鼠의 성기능에 미치는 효과
Effects of Gamimajeonojahwan Extract on the Sexual Function in Male Rats
1
조회
0
다운로드
6
인용
0
참고문헌
초록
Abstract
To evaluate effect of Gamimajeonojahwan(GMOH) water extract on sexual functions, we orally administered GMOH exract(1,100mg/kg) for four weeks in male rats impaired by 2,3,7,8-tetrachlorodibenzo-p -dioxin(TCDD) and ketoconazole(KZ). And we investigated the sexual behaviors such as mount latency, mount frequency, intromission latency, intromission frequency, ejaculation period and ejaculation latency. Serum testosterone concentrations also are evaluated in GMOH- and/or vehicle-treated male rats. The results were obtained as follows: GMOH inhibited the increase of intromission latency by TCDD in male rats. GMOH inhibited the decrease of intromission frequency by TCDD in male rats. GMOH inhibited the increase of ejaculation latency by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by KZ in male rats. These results suggest that GMOH water extract is active in improving sexual functions and protecting a decrease of testosterone concentrations induced by TCDD and KZ in male rats.
참고문헌 (17)
- "增補韓方臨床四十年", pp.255~261 (1979), 서울
- "Developmental and resproductive toxicity of dioxins and related compounds", pp.283~335 (1993)
- "Effects of developmental exposure to indole-3-carbinol or 2 8-", pp.68~75 (1996)
- "The influence of ketoconazole on human adrenal steroidogenesis Incubation studies with tissue slices", endocri(l), pp.163~168 (1991)
- "The evaluation of androgen circulating levels following castration in adult male rats", ca ro r endocri(naco m l), pp.311~318 (1988)
- "남성의 성기능 장애", pp.709~928 (1964)
- "남성성기능에 관한 연구 남성성활동에 미치는 각종 요인에 관한 임상적 연구", pp.1041~1050 (1979)
- "TCCD와 Ketoconazole에 의하여 抑制된 雄性 白鼠의 性行動 및 性호르몬에 미치는 淫羊藿合 絲子丸의 效果", pp.135~141 (1999)
- "구기쌍화탕 전탕액이 웅성 백서의 성행동 및 성호르몬에 미치는 영향", pp.152~157 (1999)
- "右歸飮 전탕액이 웅성 백서의 성행동 및 성호르몬에 미치는 영향", pp.77~83 (1999)
- "The physiology of male sexual behavior in The physiology of reproduction", k(bil e), pp.1393~1485 (1988), Raven Press
- "Endocrine Function of the Testis Recent Advance in Endocrinology and Metabo- lism", pp.111~136 (1978)
- "Textbook of Edocrinology 8-Tetrachlorodibenzo- p-dioxin increases the potency of androgens and estrogens as feedback inhibitors of Leuteinizing hormones secretion in male rat", pp.293 212~354 224, Bardin CW
- "Toxic responses of the endocrine system the basic science of poisons", pp.617~640 (1996)
- "and role in regulation of steroid hormone biosynthesis", pp.779~804 (1992)
- "Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone", pp.244~252 (1995)
- "Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone", pp.244~252 (1995)