加味六味地黃湯의 抗疲勞와 免疫 增强 效果에 대한 연구
Study on the Anti-Fatigue and Immune-Enhancing Effects of Gami-Yukmi-Jihwang-Tang
0
조회
0
다운로드
3
인용
0
참고문헌
초록
Abstract
The Korean formula medicine, Gami-Yukmi-Jihwang-Tang (GYJT) has been used for growing slowly, short of stature, incomplete development, fatigue, weak child, growing pain of child. However, it is still unclear how GYJT has an effect on experimental models. In the present study, the author investigated the immune-enhancing effect of GYJT. Forced swimming test (FST) was performed as a model of activity test in mice and measured blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactic dehydrogenase (LDH), glucose (Glc) and total protein (TP) in the serum. GYJT (1, 0.1 and 0.01 g/kg) were orally administered to mice, once per day for 7 days using a feeding atraumatic needle. After 3 days, on FST, the immobility time was significantly decreased in the GYJT (0.01g/kg/day)-fed group (120.75±5.71s) in comparison with the saline-fed group (153.80±10.74s). After 7 days, the immobility time was significantly decreased in the GYJT (0.1 and 0.01g/kg/day)-fed group (125.67±5.36s and 107.67±3.71s) in comparison with the saline-fed group (167.67±12.99s). In addition, the contents of BUN and Glc in the blood serum were significantly decreased and the contents of AST, ALT and LDH were also decreased in the GYJT (1g/kg/day)-fed group. However, the content of TP was not changed. The present results suggest that GYJT may be useful for the anti-fatigue and immune-enhancing agent. Also, the author investigated the effect of GYJT on the production of cytokines in human T-cell line, MOLT-4 cells. However, GYJT has not affected the production of IFN-γ, IL-2, IL-4. These results suggest that GYJT has immune-enhancing effect but does not affect T cell-mediated production of cytokines in the immune function improvement.
참고문헌 (38)
- "六味地黃丸의 소아질환치료에 대한 문헌적 고찰", 4(1), pp.51~65 (1990)
- "소아 외래환자의 주소증에 관한 임상적 고찰", 15(1), pp.203~216 (2001)
- "Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise", 40(3), pp.240~246 (2000)
- "Herbkines increases physical stamina in mice", 27(1), pp.117~119 (2004)
- "Antidepressant-like effects of kappa- opioid receptor antagonists in the forced swim test in rats", pp.323~330 (2003)
- "Functional diversity of helper T lymphocytes", 383(6603), pp.787~793 (1996)
- "2가 학습과 기억능력에 미치는 영향에 관한 임상연구", pp.976~988 (2002)
- "육미지황탕가미방이 흰쥐의 기억능력과 중추신경계 유전자 발현에 미치는 영향", 16(5), pp.1025~1034 (2002)
- "육미지황탕가미방이 골형성 관련 유전자인 TG2와 BMP4의 전사활성에 미치는 영향", 23(2), pp.190~197 (2002)
- "Guide for the Care and Use of Laboratory Animals" (1996), National Academy Press
- "a new animal model sensitive to antidepressant treatments", pp.730~266 732 (1977), Depression
- "Raised serum levels of tumour necrosis factor in parasitic infections", pp.1364~2 1365 (1986)
- "숙지황이 기억과 망각 속도에 미치는 영향에 대한 실험적 연구", pp.57~63 (2003)
- "숙지황이 세포성 면역반응 및 체액성 면역반응에 미치는 영향", pp.82~83 (1987)
- "산수유의 면역조절작용", 진, pp.267~271 (2002)
- "Estrogen 결핍성 골다공증에 미치는 산약 추출물의 영향", 7(1), pp.55~66 (2003)
- "황기에 의한 Helper T 세포의 생존 및 활성 증가", 15(4), pp.560~565 (2001)
- "황기가 면역세포의 기능에 미치는 영향", 13(2), pp.115~128 (1998)
- "흰쥐에서 노화관련 생리적 변화들에 미치는 인삼 및 황기의 효과", 10(2), pp.26~46 (1989)
- "백출과 구기자가 생쥐의 세포성 및 체액성 면역반응에 미치는 영향", pp.579~587 (1987)
- "홍화의 조혈작용에 대한 실험적 연구", 17(1), pp.13~28 (2003)
- "산사육이 Alzheimer's disease 병태 모델에 미치는 영향", 16(2), pp.279~288 (2002)
- "지실의 항알러지 작용에 대한 연구", pp.156~161 (2000)
- "감초와 뇌공등합제 전탕액이 마우스의 면역억제에 미치는 영향", 4(1), pp.337~359 (1994)
- "행인과 길경이 Asthma model 내의 Cytokine IL-4 IL-6에 미치는 영향", pp.31~5 38 (2000)
- "구척이 흰쥐 성장호르몬 분비에 미치는 영향", pp.133~138 (2002)
- "구척이 흰쥐의 장골 길이 성장에 미치는 영향", 16(2), pp.49~55 (2001)
- "황금과 천마의 학습 및 기억에 미치는 영향", pp.125~138 (2002)
- "Immune-enhancement effect of the herbal combination Allergina", pp.1 77~2 84 (2003), Clin Chim Acta 337
- "Effects of intrauterine and postnatal protein-calorie malnutrition on metabolic adaptations to exercise in young rats", 27(10), pp.2461~2466 (1994)
- "Pharmacological study on Agkistrodon blomhoffii blomhoffii BOIE anti-fatigue effect of the 50% ethanol extract in acute weight-loaded forced swimming-treated rats", pp.62~66 (1996)
- "expressed on human endothelial cells costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells", pp.6198~6203 (2002)
- "Tissue-level regulation of Th1 and Th2 primary and memory CD4 T cells in response to Listeria infection", j immu(l 168), pp.4504~4510 (2002)
- "TH1", TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria comparison with the allergen-induced late-phase cutaneous reaction, 2002, 694~700
- "the role of recombinant interferon-gamma therapy", pp.175~83 (2002)
- "Correlative changes of interferon-gamma and interleukin-4 between cortical layer and pulmonary airway of sensitized rats", 23(3), pp.248~52 (2002)
- "Cytokines and autoimmunity", 2(1), pp.37~45 (2002)
- "Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia", 42(4), pp.689~698 (2001)