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흰쥐의 외과적 창상에 대한 黃耆 추출액의 치료효과

Healing Effects of Astragali Radix Extracts on Experimental Open Wounds in Rats

최용복|심인섭|이혜정|이용근|김장현|장규태|김건호|함대현|한동오
한의병리학회 (The Society of Pathology in Korean Medicine)|2005.02|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제19권 제1호|pp. 92-97

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참고문헌

주제분류한의학

초록

Abstract

Inhibition of inflammatory response, acceleration of basal cell growth, and balanced synthesis of extracellular matrix (ECM) are important in healing of cutaneous open wounds. In order to evaluate the healing effects of water extracts of Radix Astragali (the root of Astragalus membranaceus (Fisch.)) on open wound at early stage, the experimental open wounds were generated on the dorsal sides of SD rats under anesthesia. The boiled-water extracts of Radix Astragali (100μl), soaked into an occlusive film dressing were applied once a day for eleven consecutive days. The healing process was assessed by measuring macroscopic appearance and wound areas of the open wounds. The molecular aspects of healing process by Radix Astragali extracts were also investigated by Hematoxylin-Eosin (H-E) double staining and immunohistological staining of collagen type I in the healed skin area, implying cell density and linear alignment of the granulation tissue, and ECM synthesis and its remodeling, respectively. The Astragali radix extracts were found to significantly accelerate the cutaneous wound healing by suppressing the inflammation and stimulating the basal cell growth in wounded area, as compared to epidermal growth factor (EGF).

참고문헌 (26)

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