玄胡索·紅花·赤芍藥이 관절염 흰쥐의 염증과 肝에 미치는 영향

Abstract

This study is designed to find out the effect of Corydalidis Tuber·Carthami Flos·Paeoniae Radix Rubra mixed water extract on adjuvant arthritis, and to check the stability for Corydalidis Tuber·Carthami Flos·Paeoniae Radix Rubra mixed water extract about the liver. At first, rats were devided into four groups; Normal(Non-treated group with FCA), Control(Group administrated saline everyday for 1 week after treatment of FCA), Sample A(group administrated Corydalidis Tuber·Paeoniae Radix Rubra·Carthami Flos mixed water extract 9㎎/200~220g everyday 1 week after treatment of FCA) and Sample B(Group administrated Corydalidis Tuber·Paeoniae Radix Rubra·Carthami Flos mixed water extract 18㎎/200~220g everyday 1 week after treatment of FCA). After then, separated searches were made on the change of edema rate, the number of WBC, the contented quantities of total protein, total bilirubin, GOT, GPT in the serum. Result : In the right planter edema, both of Sample groups showed a decrease with statistical significance in comparison with control group. In the WBC count, Sample B group showed a decrease with statistical significance in comparison with control group and also sample A group showed a decrease, but did not show statistical significance. In the serum total protein, both of samples did not show statistically significant decrease in comparison with the control group. In the serum total bilirubin, GOT and GPT, both of samples did not show any harmful change about the liver in comparison with the control group. According to the above results, it is concluded that Corydalidis Tuber·Paeoniae Radix Rubra·Carthami Flos mixed water extract had the therapeutic effect of anti-inflammation in adjuvant arthritis with no injury to liver.