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疎風湯이 고혈압과 동맥혈관에 미치는 영향

Effects of SoPung-Tang extract on Hypertension and Common Carotid Artery

조학준|최석진|김희택|김호현
한의병리학회 (The Society of Pathology in Korean Medicine)|2005.12|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제19권 제6호|pp. 1622-1628

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참고문헌

주제분류한의학

초록

Abstract

This study was undertaken to define the effect of SoPung-Tang extract on hypertension in spontaneous hypertensive rat and norepinephrine- induced arterial contraction in rabbit. In order to investigate the effect of SoPung-Tang extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of SoPung-Tang extract-induced relaxation, SoPung-Tang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, Nω-nitro-L-arginine, methylene blue or tetraethylammonium chloride. Blood pressure was significantly decreased five days after administration of SoPung-Tang extract. SoPung-Tang extract relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, SoPung-Tang extract- induced relaxation was significantly inhibited. SoPung-Tang relax arterial strip contracted by norepinephrine, but in the strips contracted by high K+, SoPung-Tang extract-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by SoPung-Tang extract was decreased by the pre-treatment of Nω-nitro-L-arginine or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When Ca2+ was applied, the strips which were contracted by norepinephrine in a Ca2+-free solution, arterial contraction was increased. But pre-treatment of SoPung-Tang extract inhibited contractile response to Ca2+. We suggest that SoPung-Tang could be applied effectively for hypertension and may suppress influx of extra-cellular Ca2+ through the formation of nitric oxide in the vascular endothelial cells.

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