加味補陽還五湯의 抗血栓 및 抗炎作用에 대한 실험적 연구
Experimental Study on Anti-thrombotic and Anti-inflammatory Effect of Kami-BoyangHwanoh-Tang
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Abstract
This study was performed to evaluate antithrombotic activities and anti-inflammatory effects of Kami-BoyangHwanoh-Tang(KBHT). The major findings were summarized as follows. In experiment of anti-thrombotic effect; KBHT inhibited human platelet aggregation induced by ADP and epinephrine as compared with the control group and inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 50 %). KBHT increased platelet number significantly and also KBHT shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. In experiment of anti-inflammatory effect; KBHT inhibited IL-1β, IL-6, TNF-α, COX-2 and NOS-II mRNA expression as compared with the control group in a concentration-dependent degree, and inhibited NO production significantly at 50, 100 ㎍/㎖, and also inhibited ROS production in a concentration-dependent degree as compared with the control group in RAW 264.7 cell line. KBHT inhibited IL-1β, IL-6 and TNF-α production significantly in serum of acute inflammation-induced mice, and decreased IL-1β, IL-6 and TNF-α production in spleen tissue, and also decreased IL-6 and TNF-α production in liver tissue, but increased IL-1β production in liver tissue of acute inflammation-induced mice. KBHT increased survival rate at 3rd day in mice with lethal endotoxemia induced by LPS. These results suggest that KBHT can be useful in treating diverse female diseases caused by thrombosis and inflammation such as endometrosis, myoma, pelvic congestion, chronic cervicitis, chronic pelvic inflammatory disease and so on.
참고문헌 (38)
- 羅元愷 主編, "實用中醫婦科學", pp.~13 (1996), 上海科學技術出版社
- 宋炳基, "韓方婦人科學", pp.17~19 (1995), 행림출판
- 한의부인과학 교재편찬위원회, "韓醫婦人科學 上", pp.~61 (2002), 도서출판 정담
- 郭 玲 외, "血府逐瘀湯膠囊治療慢性骨盤炎 17例", 21(3), pp.192~193 (2002)
- 易法銀 主編, "中醫瘀血證診療大全", pp.1~11 (1999), 中國中醫藥出版社
- 張之南 외, "血瘀證與活血化瘀硏究", pp.429~431 (1990), 上海科學技術出版社
- 安圭錫, "瘀血病態모형 개발에 관한 연구", 13(1), pp.25~34 (1999)
- 鄭學洙, "흰쥐에서 endotoxin으로 유발된 파종성 혈관내 응고증에 대한 桃仁湯의 항혈전 효과", 14(1), pp.133~145 (2001)
- 孫泰熏, "加味生化湯의 抗血栓 및 鎭痛效果에 對한 硏究" (2001), 大田大學校 大學院
- 이혜경, "加味通經湯의 抗血栓 消炎 및 鎭痛作用에 對한 硏究" (2002), 大田大學校 大學院
- 朴炳烈, "少腹逐瘀湯이 항혈전 및 소염 진통에 미치는 영향", pp.81~96 (1996)
- 고승희 외 8인, "蘇木이 endotoxin으로 유발된 어혈병태모델에 미치는 영향", pp.39~44 (2001)
- 윤시진, "赤芍藥이 관절염 흰쥐의 염증과 간에 미치는 영향" (2004), 경원대학교 대학원
- 김동일, "만성골반통을 유발하는 골반울혈증후군의 임상에 관한 연구", 대한한방부인과학회지, 15(2), pp.114~125 (2002), 대한한방부인과학회
- 熊福榮, "補陽還五湯應用擧隅", 22(2), pp.65~ (2003)
- 王如英, "活血祛瘀法治療子宮內膜異位症的臨床觀察", 24(3), pp.258~259 (2004)
- Lee, "Protective effects of Phellinuslinteus on reperfusion of the isolated perfused Guinea pig hearts andanti-platelet aggregation effects of Phellinus linteus", pp.17~25 (1994)
- Guerra-Fernando, J.I, "Effect of losartan on human platelet activation", pp.447~452 (1999)
- Kimura, "Effect of cilostazol on platelet aggregation and experimental thrombosis", pp.1144~1149 (1985)
- Fonio, "On the retraction process in blood plasma coagulation", 36(5), pp.371~385 (1966)
- Leadley, R.J, "Pharmacodynamic activity and antithrombotic efficacy of RPR120844 a novel inhibitor of coagulation factor Xa", pp.791~799 (1999)
- Stanley, "Pathologic basis of disease", pp.99 117 318 623~114 121 319 626 (1994)
- 李紅梅, "少腹逐瘀湯直腸灌注治療子宮線肌症 32例", 21(5), pp.292~ (2002)
- Kim, E.J, "Suppression by a sesquiterpene lactone from Carpesium divaricantum of inducible nitric oxide synthase by inhibiting nuclear facter-kB activation", pp.903~910 (2001)
- 최승만 외, "Propionibacterium acnes에 대한 천연물의 항균효과 검색", pp.89~94 (1998)
- 송계용, "핵심 병리학", pp.62~94 (1998)
- 설인찬, "加味補陽還五湯이 고지혈증 고혈압 및 뇌손상에 미치는 영향", pp.133~162 (1998)
- 정우상 외 5인, "고혈압 및 고지혈증에 대한 補陽還五湯의 실험적 연구", 18(2), pp.246~267 (1997)
- 우수경, "인체에 대한 cilostazol의 항혈소판 응집 작용과 심혈관계 작용에 대한 PK", PD modeling, 2001, ~[DOI]
- Konstantinides, S.,, "Inhibition of endogenous leptin protects mice from arterial and venous thrombosis", pp.2196~2201 (2004)
- 홍천수 譯, "Pathophysiology로 이해하는 내과학", pp.10~12 (2002), 도서출판 정담
- Aeberi, D.,, "Inhibition of the TNF-pathway use of infliximab and etanercept as remission-inducing agents in case of therapy-resistant chronic inflammatory disorders", pp.414~422 (2002)
- Charles, N.,, "Expression of cyclooxygenase-2 in cervical", pp.1174~1176 (2003)
- 지병철, "Nitric Oxide가 인간 황체화 과립막세포의 아포프토시스에 미치는 영향", 45(5), pp.766~773 (2002)
- 서영준, "발암과정에 있어서 Cyclooxigenase-2의 역할 및 그 저해를 통한 화학 암 예방", pp.8~17 (2002)
- Levi Marcel, "Current conceptions; disseminated intravascular coagulation", pp.586~592 (1999)
- Hermida, "Endotoxin-induced disseminated intravascular coagulation in rabbits effect of recombinant hirudin on hemostatic parameters", pp.77~83 (1998)
- Hermida, "Endotoxin-induced disseminated intravascular coagulation in rabbits effect of recombinant hirudin on hemostatic parameters", pp.77~83 (1998)