매생이 추출분획의 암 예방 및 면역증진 효과
Effects of Cancer Prevention and Immune Stimulation of Fractions from Capsosiphon fulvescens
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Abstract
The fractions of Capsosiphon fulvescens were studied to verify the anticancer and immunostimulating activity. The fractions from the ethanol extract of C. fulvescen were prepared by the systematic extraction procedure with the solvents such as hexane, ethyl ether, methanol, butanol and H2O. The cytotoxic effects of C. fulvescens fractions against human leukemia cell line U937, mouse neuroblastoma cell line (NB41A3), human hepatoma cell line (HepG2) and rat glioma cell line (C6) were investigated. Ethyl ether fraction of C. fulvescens showed the highest cytotoxicity against all four cell lines tested. In addition, H2O fraction also showed relatively high cytotoxicity. Dose dependent patterns were observed on all four cell lines. The immuno-stimulating effects of C. fulvescens fractions on rat macrophage cell line (RAW 264.7) were also investigated. All five fractions of C. fulvescens extract stimulated NO production with concentration dependant manner. These results suggest that C. fulvescens may be a useful candidate for a natural antitumor and immuno-stimulating agent.
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