Effects of Angelicae Gigantis Radix on Noise Stress-induced c-Fos Expression in Rats
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Abstract
Previous studies reported that exposure to noise during pregnancy adversely influenced the development of the fetus and neonate. In Oriental medicine, medications based on Angelicae gigantis radix have been known to be of efficacy in the treatment of various diseases. c-Fos, an immediate early gene whose expression is sometimes used as a marker for stimulus-induced changes in the metabolic activity of neurons. In the present study, the influence of postnatal Angelicae gigantis radix administration on c-Fos expression in the each region of hippocampus of offspring rats with prenatal noise stress during pregnancy was investigated. From the present results, exposure to the prenatal stress during pregnancy enhanced c-Fos expression, whereas exposure to postnatal Angelicae gigantis radix suppressed c-Fos expression in the offsprings with prenatal noise stress during pregnancy. Based on the present study, Angelicae gigantis radix may provide new therapeutic opportunities as an agent to counteract the effects of prenatal noise stress- induced hippocampal dysfunction, and may be useful in the treatment of psychiatric problems in children of mothers who have experienced noise stress during pregnancy.
참고문헌 (22)
- "Gestational exposure to loud noise alters the development and postnatal responsiveness of humoral and cellular components of the immune system in offspring", 73, pp.227~241 (1997)
- "Prenatal stress depresses immune function in rats", 63, pp.397~402 (1998)
- "Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys", 54, pp.1025~1034 (2003)
- "L.E. On the role of the hippocampus in learning and memory in the rat. Behav. Neural Biol. 60", pp.9~26 (1993)
- "G. The structure and organization of memory. Annu. Rev. Psychol. 44", pp.453~495 (1993)
- "R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Methods 29", dragu(w), pp.261~265 (1989)
- "Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety", 713, pp.79~91 (1996)
- "Immediate early gene expression to examine neuronal activity following acute and chronic stressors in rat pups: Examination of neurophysiological alterations underlying behavioral consequences of prenatal cocaine exposure", 61, pp.895~902 (1997)
- "Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats", 378, pp.44~48 (2005)
- "Molecular genetic and chemical assessment of radix Angelica (Danggui) in China", 51, pp.2576~2583 (2003)
- "Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury", 69, pp.637~646 (2001)
- "Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats", 9, pp.2786~2789 (2003)
- "Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats", 35, pp.118~129 (2004)
- "A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats", 26, pp.259~268 (2002)
- "Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus", 97, pp.11032~11037 (2000)
- "J.I. Continuous c-Fos expression precedes programmed cell death in vivo. Nature 363", pp.166~169 (1993)
- "F. Immediate-early gene induction after neuronal hypoxia-ischemia. Mol. Brain Res. 18", pp.228~238 (1993)
- "Induction of apoptosis by c-Fos protein", 16, pp.211~218 (1996)
- "Effects of combined prenatal stress and toluene exposure on apoptotic neurodegeneration in cerebellum and hippocampus ofrats", 94, pp.169~176 (2004)
- "Exposure to short-lasting impulse noise causes neuronal c-Jun expression and induction of apoptosis in the adult rat brain", 19, pp.985~991 (2002)
- "Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensisin rats", 66, pp.348~351 (2000)
- "Protective effect of a traditional Japanese medicine, Bu-zhong-yi-qi-tang (Japanese name: Hochu-ekki-to), on the restraint stress-induced susceptibility against Listeria monocytogenes", 48, pp.35~42 (2000)