송이버섯과 동충하초 균사체 혼합배양 추출물의 투여가 Streptozotocin으로 유발한 당뇨 쥐의 혈당에 미치는 영향
Effects of Extracts from Mixed Culture with Tricholoma Matsutake Mycelium and Cordyceps Militaris Mycelium on Blood Glucose in Streptozotocin-Induced Diabetic Rats
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초록
This study was performed to investigate the influence of extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium on hypoglycemia in streptozotocin-induced diabetic rats. Experimental animals were divided into 7 groups : normal control group(NC), diabetes control group (DC), positive control group(PC), non-fermented OCM(oriental medicine & cereal medium) extracts group (UM), crude polysaccharide of non-fermented OCM extracts group (UME), fermented OCM extracts group (UF), crude polysaccharide of fermented OCM extracts group (UFE). NC, DC groups were orally administered saline, PC group was orally administered acarbose. UM, UME, UF, UFE groups were orally administered each extract once a day for 14days. Blood glucose level was lower in the all administering OCM extract groups (UM, UME, UF, UFE) than in the diabetes group(p<0.05), and specially UF, UFE groups were similar to tendency of PC group. ALT, ALP activity in OCM groups were not significantly lowered than PC group(p<0.05). AST activity was not different with PC group. The results of this study show that extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium may have a beneficial effect on the hypoglycemia.
Abstract
This study was performed to investigate the influence of extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium on hypoglycemia in streptozotocin-induced diabetic rats. Experimental animals were divided into 7 groups : normal control group(NC), diabetes control group (DC), positive control group(PC), non-fermented OCM(oriental medicine & cereal medium) extracts group (UM), crude polysaccharide of non-fermented OCM extracts group (UME), fermented OCM extracts group (UF), crude polysaccharide of fermented OCM extracts group (UFE). NC, DC groups were orally administered saline, PC group was orally administered acarbose. UM, UME, UF, UFE groups were orally administered each extract once a day for 14days. Blood glucose level was lower in the all administering OCM extract groups (UM, UME, UF, UFE) than in the diabetes group(p<0.05), and specially UF, UFE groups were similar to tendency of PC group. ALT, ALP activity in OCM groups were not significantly lowered than PC group(p<0.05). AST activity was not different with PC group. The results of this study show that extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium may have a beneficial effect on the hypoglycemia.
참고문헌 (22)
- The Bureau of statistics, "Statistical annual of mortality cause", pp.37~ (1996), The Bureau of statistics
- 許浚, "對譯東醫寶鑑", pp.1331~1339 (1998), 法仁文化史
- Hillebrand, I., "The effects of the alpha-glucosidase inhibitor BAYg5421(Acarbose) on meal-stimulated elevations of circulating glucose, insulin and triglyceride levels in man", Res Exp Med, 175, pp.81~86 (1979)
- Korean Forestry Reports, "Reports on the pinemushroom in Korea forest Research Institute", Korean Forestry Reports, 통권 : 18, pp.44~46 (1981)
- Newman, R.K., "Hypercholesterolmic effect of bareley foods on healthymen", Nutr. Rep. Inc, 39, pp.749~760 (1989)
- Oh, H.J., "physiological function in vitro of beta-glucan isolated from barely", Korean J Food Sci Technol, 28(4), pp.689~695 (1996)
- Lee, S.E., "Changes in quality of shiitake mushroom(Lentinus edodes) during modified atmoshere storage", J. Korean Soc. Food Nutr, 20, pp.133~138 (1991)
- Kim, D.M., "Effect of Co2 concentration in ca condition on the quality of shiitake mushroom(Lentinus edodes) during storage", Korean J Food Sci Technol, 21, pp.461~467 (1989)
- An, J.S., "Studies on the mineral contents of Korean mushroom", Korean J Food Hygime and Safty, 1(2), pp.177~179 (1986)
- 오세욱, "동충화초 품종별 영양성분 비교", 한국식품과학회지, 35(1), pp.15~22 (2003), 한국식품과학회
- Beppu, H., "Dieabetogenic action of streptozotocin : essential role of membrane permeability", Acta. Endocrinol. (Copdhn), 114, pp.90~96 (1987)
- Woo, T.Y., "Effect of royal jelly on therapy and prevention of streptozotocin-induced diabetic rats", J Korean Soc Food Sci Nutr, 27, pp.1267~1272 (1998)
- Shon, K.H., "Pretreatment with nicotinamide to prevent the pancreatic enzymes changes by streptozotocin in rats", J Korean Soc Food Nutr, 21, pp.117~123 (1992)
- Harvey, J.N., "Renal kallikvein and hemodynamic abnormalities of kidney", Diabetes, 39, pp.299~304 (1990)
- Kwang, O.G., "Effects of vitamin E on the anti-oxidative system of kidney in streptozotocin- induced diabetic rats", J Korean Soc Food Nutr, 28(3), pp.654~662 (1999)
- Lim, S.J., "Hypoglycemic effect of fractions of Cassiatora extract in streptozotocin-induced diabetic rats", J Korean Soc Food Nutr, 13(1), pp.23~29 (1997)
- Urano, S., "Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics", Lipids, 26, pp.58~61 (1991)
- Rho, H.M., "Effects of raw soy enzyme activity in streptozotocin-diabetic rats", J Korean Soc. Food Sci. Nutr, 27, pp.724~730 (1998)
- Choi, J.W., "The effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats", J Korean Soc Food Nutr, 20, pp.306~311 (1991)
- Yun, Y.G., "An experimental study on the effect streptozotocin upon the kidney in rats", J Hanyang Med Coll, 11, pp.155~173 (1991)
- Kwack, K.H., "The effects of yukmijihwang- tang and discoreae radix on the change of blood glucose and serum in diabetic rats induced by alloxan", Kyunghee Med, 8, pp.388~398 (1993)
- Kui, N.Y., "Clinical pathoogy file. 3th ed", pp.95~1550 (2000), Eui-Hak Publishing & Printing Company