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한약의 방사선 부작용 억제효과에 관한 경향 분석

Study for Research Trends on Radioprotective Effects of Herbs

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초록

Cancer is already a well-recognized main cause of mortality and the incidence of cancer is increasing steadily. Because conventional treatment modalities for cancer accompanies severe side effects, traditional medicine has been considered as alternatives to reduce the adverse effects and its use has continued to rise in cancer therapy. This study aims to summarize and make a reference of radioprotective effects of herbs worldwide. In this process, this review surveyed all papers of radioprotective-focused studies using herbal medicine in PubMed database and finally 44 papers were included. The type of materials, formation of experiments, type of herbal medicine, their action and mechanisms, and type of cancer were analyzed. The number of studies on radioprotective effects of herbal medicine has increased since 2000. The main formation of experiments was clinical study and the portion was 45% and the proportion of the research using prescriptions was 51% and the research using herbal products was 25%. Herbs and prescriptions having the effects of tonifying and nourishment were used the most. Most of herbal medicine in this study can enhance immune function, increase anti-oxidant effect, regulate cell cycle and increase sensitivity to radiotherapy. This study will provide the useful information on development of herbal medicine having radioprotective effects.

Abstract

Cancer is already a well-recognized main cause of mortality and the incidence of cancer is increasing steadily. Because conventional treatment modalities for cancer accompanies severe side effects, traditional medicine has been considered as alternatives to reduce the adverse effects and its use has continued to rise in cancer therapy. This study aims to summarize and make a reference of radioprotective effects of herbs worldwide. In this process, this review surveyed all papers of radioprotective-focused studies using herbal medicine in PubMed database and finally 44 papers were included. The type of materials, formation of experiments, type of herbal medicine, their action and mechanisms, and type of cancer were analyzed. The number of studies on radioprotective effects of herbal medicine has increased since 2000. The main formation of experiments was clinical study and the portion was 45% and the proportion of the research using prescriptions was 51% and the research using herbal products was 25%. Herbs and prescriptions having the effects of tonifying and nourishment were used the most. Most of herbal medicine in this study can enhance immune function, increase anti-oxidant effect, regulate cell cycle and increase sensitivity to radiotherapy. This study will provide the useful information on development of herbal medicine having radioprotective effects.

참고문헌 (46)

  1. "2008년 사망원인통계 결과"[URL]
  2. Takegawa, Y, "Can Kampo therapy prolong the life of cancer patients?", J Med Invest, 55(1), pp.99~105 (2008)
  3. Zhuang, S.R, "Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy", radiotherapy, 2009, pp.23(6), 785~790
  4. Yates, J.S, "Prevalence of complementary and alternative medicine use in cancer patients during treatment", Support Care Cancer, 13(10), pp.806~811 (2005)
  5. Cui, Y, "Use of complementary and alternative medicine by chinese women with breast cancer", Breast Cancer Res Treat, 85(3), pp.263~270 (2004)
  6. Tang, Z.Y, "Treatment of primary liver cancer-with special reference to the east part of China", Ann Acad Med Singapore, 9(2), pp.251~255 (1980)
  7. 전국한의과대학 본초학교수, "본초학", pp.151~ (1991), 영림사
  8. Hong, J, "An analysis of the long-term therapeutic effect of the integrated therapy of traditional Chinese medicine and radiotherapy on abdominal malignant tumor", J Tradit Chin Med, 25(2), pp.125~128 (2005)
  9. Yang, Y.F, "Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation", Chin J Integr Med, 14(4), pp.251~256 (2008)
  10. Xu, G.Z, "Chinese herb "destagnation" series I: Combination of radiation with destagnation in the treatment of nasopharyngeal carcinoma (NPC): a prospective randomized trial on 188 cases", Int J Radiat Oncol Biol Phys, 16(2), pp.297~300 (1989)
  11. Bao, Y.X, "Clinical studies of immunomodulatory activities of Yunzhi-Danshen in patients with nasopharyngeal carcinoma", J Altern Complement Med, 12(8), pp.771~776 (2006)
  12. Han, W, "Qiu Baoguo's experience in treating consumptive syndromes after radio-chemotherapies", J Tradit Chin Med, 28(2), pp.122~128 (2008)
  13. Pongnikorn, S, "Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy", J Med Assoc Thai, 86(1), pp.61~68 (2003)
  14. Dai, A.W, "Effect of Yangyin Humo Decoction on oral mucomembranous reaction to radiotherapy", Chin J Integr Med, 15(4), pp.303~306 (2009)
  15. Takeda, T, "Effectiveness of the herbal medicine daikenchuto for radiation-induced enteritis", J Altern Complement Med, 14(6), pp.753~755 (2008)
  16. Putwatana, P, "Relief of radiation-induced oral mucositis in head and neck cancer", Cancer Nurs, 32(1), pp.82~87 (2009)
  17. Wu, M.H, "Study of qingre liyan decoction in treating and preventing acute radioactive oral mucositis", Chin J Integr Med, 13(4), pp.280~284 (2007)
  18. He, Z.F, "Effect of Kang'ai Injection on serum level of soluble interleukin-2 receptor and vascular endothelial growth factor in patients with esophageal carcinoma during radiotherapy", Chin J Integr Med, 12(4), pp.273~276 (2006)
  19. Zhao, J.X, "Effects of body-resistance strengthening and tumor-suppressing granules on immune adhesion function of red blood cells and expression of metastasis protein CD44 in tumor cells of patients with esophageal carcinoma", World J Gastroenterol, 13(32), pp.4360~4364 (2007)
  20. Zheng, Y, "The therapeutic effects of rehmannia oral liquid for the syndrome of heat accumulation with Yin consumption in esophagus cancer patients undergoing radiotherapy-a report of 60 cases", J Tradit Chin Med, 27(4), pp.248~254 (2007)
  21. Hien, T.V, "Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60", Integr Cancer Ther, 1(1), pp.38~44 (2002)
  22. Lan, X, "The therapeutic effects of the radiotherapy plus TCM treatment observed in senile non-parvicellular lung cancer patients at the late stage", J Tradit Chin Med, 23(1), pp.32~34 (2003)
  23. Shen, R.N, "Naturin: a potent bio-immunomodifier in experimental studies and clinical trials", In Vivo, 10(2), pp.201~209 (1996)
  24. Zhang, R.J, "Medicinal protection with Chinese herb-compound against radiation damage", Aviat Space Environ Med, 61(8), pp.729~731 (1990)
  25. Cui, H, "Therapeutic effects of the combined Chinese and Western medicine on metastatic carcinoma in the supraclavicular lymph nodes-an analysis of 285 cases", J Tradit Chin Med, 15(2), pp.87~89 (1995)
  26. Chen, F.D, "Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax notoginseng extract", Am J Chin Med, 29(3), pp.517~524 (2001)
  27. Devi, P.U, "Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180", Indian J Exp Biol, 31(7), pp.607~611 (1993)
  28. Devi, P.U, "Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization", Indian J Exp Biol, 34(10), pp.927~932 (1996)
  29. Dai, Y, "Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer", Int J Radiat Oncol Biol Phys, 74(4), pp.1217~1225 (2009)
  30. Chen, Y, "Effects of tetrandrine plus radiation on neuroblastoma cells", Anticancer Res, 29(8), pp.3163~3171 (2009)
  31. Devi, P.U, "In vivo tumor inhibitory and radiosensitizing effects of an Indian medicinal plant, Plumbago rosea on experimental mouse tumors", Indian J Exp Biol, 32(8), pp.523~528 (1994)
  32. Lin, I.H, "Effects of glycyrrhizae and glycyrrhizic acid on cellular immunocompetence in low-dose gamma-ray irradiated mice", Changgeng Yi Xue Za Zhi, 22(3), pp.370~377 (1999)
  33. Xiao, Z, "Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis", Int J Radiat Oncol Biol Phys, 65(3), pp.882~889 (2006)
  34. Rekha, P.S, "Effect of herbal preparation, brahma rasayana, in amelioration of radiation induced damage", Indian J Exp Biol, 38(10), pp.999~1002 (2000)
  35. Kumar, P, "Radioprotective effects of Rasayanas", Indian J Exp Biol, 34(9), pp.848~850 (1996)
  36. Ma, Z.C, "Proteomic analysis of the effects of tetramethylpyrazine on irradiated QXMSC1 cells", Biol Pharm Bull, 30(2), pp.397~402 (2007)
  37. Chae, S, "Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo", J Agric Food Chem, 57(13), pp.5777~5782 (2009)
  38. Mittal, A, "Influence of Podophyllum hexandrum on endogenous antioxidant defence system in mice: possible role in radioprotection", J Ethnopharmacol, 76(3), pp.253~262 (2001)
  39. Vayalil, P.K, "Protective effects of Rasayanas on cyclophosphamide- and radiation-induced damage", J Altern Complement Med, 8(6), pp.787~796 (2002)
  40. Park, S.G, "Tetra-arsenic oxide (Tetras) enhances radiation sensitivity of solid tumors by anti-vascular effect", Cancer Lett, 277(2), pp.212~217 (2009)
  41. Han, G, "Angelica sinensis down-regulates hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis", Radiat Res, 165(5), pp.546~552 (2006)
  42. Ma, H, "Clinical effects of lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy", J Tradit Chin Med, 27(3), pp.193~196 (2007)
  43. Liu, W.C, "Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine", Radiat Res, 166(6), pp.900~907 (2006)
  44. 강연이, "韓醫學의 抗腫瘍 免疫治療에 관한 연구-1990年 以後 發表된 實驗論文을 中心으로-", 동의생리병리학회지, 17(1), pp.1~24 (2003), 대한동의병리학회
  45. Taylor, C.W, "Chinese herbal remedies and radiotherapy", Clin Oncol (R Coll Radiol), 5, pp.431~432 (2002)
  46. Feigen, M, "Fatal veno-occlusive disease of the liver associated with herbal tea consumption and radiation", Aust N Z J Med, 14(1), pp.61~62 (1984)

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