CCTA 영상에서 계층적 변형을 이용한 심혈관 비강체 정합
Non-rigid registration based on hierarchical deformation of coronary arteries in CCTA images
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초록
본 논문에서는 관상동맥 질환의 진단 및 치료에 활용 가능한 보조 정보 제공을 위해 동일 환자 시간차 3D 심장 컴퓨터단층촬영 혈관 조영술 영상에서 혈관 간 정확하고 빠른 비강체 정합 기법을 제안한다. 제안 방법은 다음과 같은 네 단계로 구성된다. 첫째, 시간차 3D 심장 컴퓨터단층촬영 혈관 조영술 영상으로부터 획득한 3D 혈관 중심선 간에 강체 정합을 통한 전역적 정렬을 수행한다. 둘째, 강체 정합 결과에서 3D 혈관 중심선 간 Point matching을 수행하며 대응 관계를 정의한다. 셋째, 혈관의 두께, 기울기 등의 정보를 이용하여 매칭된 대응 관계에서 Outlier를 제거한다. 넷째, 에너지 함수를 이용하여 계층적인 지역적 변형을 위한 비강체 변형 수행한다. 실험 결과, 제안 기법의 평균 정합 오차는 0.987mm이고, 평균 수행 시간은 2.137초로 정확하고 빠르게 정합을 수행한다.
Abstract
In this paper, we propose a accurate and fast non-rigid registration method between vessels using two 3D cardiac computed tomography angiography(CTA) images taken at different times to provide auxiliary information that can be used in the diagnosis and treatment of coronary artery disease. The proposed method consists of the following four steps. First, global alignment is performed through rigid registration between 3D vessel centerlines acquired from two 3D CTA images. Second, corresponding points is obtained through point matching between 3D vessel centerlines. Third, the outlier is removed from the corresponding points using the thickness and gradient of the vessel. Fourth, non-rigid deformation for hierarchical local transformation is performed using an energy function. As a result of the experiment, the average registration error is 0.987 mm, and the average execution time is 2.137 seconds. The proposed method shows that the registration is performed accurately and quickly.
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