당뇨환자에서 자가관리형 베타케톤검사의 유효성: 체계적 문헌 고찰 및 메타분석
The Effectiveness of Blood β-ketone Testing in Patients with Diabetic Ketosis: A Systematic Review & Meta-analysis
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Objectives: The effectiveness of Blood β-ketone testing by using self-monitoring strip on diabetic patients. Methods: Clinical effectivenessof blood β-ketone testing was assessed through correlation with reference test that measured blood β-ketone value through gaschromatography or enzyme method, diagnostic accuracy, time taken for the test and time taken for confirmative diagnosis of diabeticketosis by selecting literatures on researches that conducted this test on ketosis(suspected) patients or diabetic ketosis(suspected) patients. Each of the stages from literature search to application of selection standards and extraction of data were carried out independently bythe Subcommittee along with 2 researchers. Results: 7 reports were selected. β-ketone testing displayed high level of correlation in therange of r=0.92～0.99 with test using enzyme method as the reference standard. Regarding the diagnostic accuracy, sensitivity of 0.82,specificity of 0.74. The time taken for the test was 30seconds for the index test, which is shorter than reference standard test. Conclusion: Blood β-ketone testing was assessed to be a safe and effective test to monitor ketosis and assess the level of risk of ketosis by measuring the blood β-ketone on ketosis patients and diabetic ketosis patients since it has high level of correlation with reference test and short period of testing.
Abstract
Objectives: The effectiveness of Blood β-ketone testing by using self-monitoring strip on diabetic patients. Methods: Clinical effectivenessof blood β-ketone testing was assessed through correlation with reference test that measured blood β-ketone value through gaschromatography or enzyme method, diagnostic accuracy, time taken for the test and time taken for confirmative diagnosis of diabeticketosis by selecting literatures on researches that conducted this test on ketosis(suspected) patients or diabetic ketosis(suspected) patients. Each of the stages from literature search to application of selection standards and extraction of data were carried out independently bythe Subcommittee along with 2 researchers. Results: 7 reports were selected. β-ketone testing displayed high level of correlation in therange of r=0.92～0.99 with test using enzyme method as the reference standard. Regarding the diagnostic accuracy, sensitivity of 0.82,specificity of 0.74. The time taken for the test was 30seconds for the index test, which is shorter than reference standard test. Conclusion: Blood β-ketone testing was assessed to be a safe and effective test to monitor ketosis and assess the level of risk of ketosis by measuring the blood β-ketone on ketosis patients and diabetic ketosis patients since it has high level of correlation with reference test and short period of testing.
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