중약주사제 부작용 발생에 관한 분석 연구
An Analytic Study on the Occurrence of Adverse Drug Reactions of Traditional Chinese Medicine Injections
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The purpose of this study is to analyze the side effects (ADR) of Traditional Chinese Medicine (TCM) injections by age, injection type, symptoms, and causes, and to find preventive solutions for ADR. For the ADR of TCM injection data collected during the search period from January 1, 2010 to December 31, 2020, the correlation between each section was analyzed by subdividing it into age, injection type, symptoms and causes. CNKI, PubMed, and EMBASE were used to collect the clinical data. ‘Chinese herbal injection', 'Traditional Chinese Medicine injection', 'Chinese herbal injection side effect', 'Chinese herbal injection adverse drug reaction' were used for the keyword from the database. All data were collected mainly for TCM injection and the causes of ADR due to TCM injection. However, data not related to the relevant study or TCM injection were excluded from this study. Among a total of 941 studies collected during the search period from January 1, 2010 to December 31, 2020, a total of 10 studies were selected for final analysis. In 1462 clinical data sets, ADR by gender was higher in males than females. By age, 41 to 60 years were the most common. The incidence of ADR by injection type was highest in the blood regulating injection type. Data analysis showed Xueshuantong injection had the highest ADR. Among the symptoms of ADR, skin diseases were the most common. The most common cause of ADR was the unreasonable use of drugs. In China, for ADR management, the use of TCM injections is recommended according to the basic principles for the clinical use of TCM injections established by the Chinese government. In this study, we analyzed the current status and causes of ADR in TCM injections, and found a preventive solution. It is expected that it can be used as basic data to increase the usability of pharmacopuncture and herbal medicines in Korea in the future.
Abstract
The purpose of this study is to analyze the side effects (ADR) of Traditional Chinese Medicine (TCM) injections by age, injection type, symptoms, and causes, and to find preventive solutions for ADR. For the ADR of TCM injection data collected during the search period from January 1, 2010 to December 31, 2020, the correlation between each section was analyzed by subdividing it into age, injection type, symptoms and causes. CNKI, PubMed, and EMBASE were used to collect the clinical data. ‘Chinese herbal injection', 'Traditional Chinese Medicine injection', 'Chinese herbal injection side effect', 'Chinese herbal injection adverse drug reaction' were used for the keyword from the database. All data were collected mainly for TCM injection and the causes of ADR due to TCM injection. However, data not related to the relevant study or TCM injection were excluded from this study. Among a total of 941 studies collected during the search period from January 1, 2010 to December 31, 2020, a total of 10 studies were selected for final analysis. In 1462 clinical data sets, ADR by gender was higher in males than females. By age, 41 to 60 years were the most common. The incidence of ADR by injection type was highest in the blood regulating injection type. Data analysis showed Xueshuantong injection had the highest ADR. Among the symptoms of ADR, skin diseases were the most common. The most common cause of ADR was the unreasonable use of drugs. In China, for ADR management, the use of TCM injections is recommended according to the basic principles for the clinical use of TCM injections established by the Chinese government. In this study, we analyzed the current status and causes of ADR in TCM injections, and found a preventive solution. It is expected that it can be used as basic data to increase the usability of pharmacopuncture and herbal medicines in Korea in the future.
참고문헌 (55)
- Park JM, "Pharmacopuncture in Korea: A systematic review and meta-analysis of randomized controlled trials", Evid Based Complement Alternat Med., pp.1~19 (2016)[DOI]
- 안상우, "A reference to the original source of herb-acupuncture in methods", Journal of Pharmacopuncture, 1(1), pp.87~102 (1997), 대한약침학회[DOI]
- 송건의, "중국에서의 약침을 활용한 불면증 치료 임상논문 연구동향", 동의신경정신과학회지, 30(3), pp.265~274 (2019), 대한한방신경정신과학회[DOI]
- Wang HY, "Discussion of Rational Use of Traditional Chinese Medicine in View of Dosage Forms", China Pharmacy, 21(43), pp.4127~4128 (2010)
- 최송이, "중약 제형의 연구동향", 한약정보연구회지(韓藥情報硏究會誌), 4(3), pp.11~19 (2016), 한약정보연구회[DOI]
- Xu Y, "Integrative analysis of proteomics and metabolomics of anaphylactoid reaction induced by Xuesaitong injection", J Chromatogr A, 1416, pp.103~111 (2015)
- 정창운, "중약주사제의 약물유해반응: 아나필락시스 반응을 중심으로", 한방재활의학과학회지, 30(4), pp.133~142 (2020), 한방재활의학과학회[DOI]
- Li H, "Traditional Chinese herbal injection : Current status and future perspectives", Fitoterapia, 129, pp.249~256 (2018)
- Ye JH, "Analysis of 111 cases adverse reaction in Traditional Chinese Medicine injection", Journal of Tonghua Normal University, 40(10), pp.36~38 (2019)[DOI]
- "National annual report on drug adverse reaction monitoring" (2020)[URL]
- Song L, "Analysis and countermeasures of clinical adverse drug reactions of Traditional Chinese Medicine injections", J of Clinical Medical Literature(Electronic Edit), 3(46), pp.9111~9112 (2016)[DOI]
- Liu HM, "Reason analysis and countermeasure exploration of adverse reactions of Chinese Medicine injection", Journal of Pharmaceutical Research, 35(07), pp.431~434 (2016)[DOI]
- Lu H, "Analysis and preventive measures of adverse drug reaction causes in Traditional Chinese Medicine injections", China Journal of Pharmaceutical Economics, 9(10), pp.22~23 (2014)
- Park JE, "et al. Usage status and satisfaction with pharmacopuncture in Korea : A survey among Korean medicine doctors", European Journal of Integrative Medicine, 27, pp.121~130 (2019)[DOI]
- 이한길, "중국과 국내에서의 약침 관련 임상논문 비교 연구 - 근골격계 및 신경계 질환을 위주로 -", 한방재활의학과학회지, 19(3), pp.47~67 (2009), 한방재활의학과학회
- Zhang T, "Analysis of 149 cases of Chinese medicine injection in our hospital", Chinese Journal of Ethnomedicine and Ethnopharmacy, 28(10), pp.126~131 (2019)
- Tang ZS, "A review of causes and preventive countermeasures about 127Cases of adverse drug reactions in Traditional Chinese Medicine injection", Heilongjiang Medicine Journal, 30(6), pp.1237~1239 (2017)
- Zhang XH, "A Summary of 135 Adverse Injection Reactions of Chinese Medicines in a HospitalExploring the Causes", Journal of China Prescription Drug, 14(10), pp.42~44 (2016)
- Wang XP, "Reasons and Countermeasure Analysis of Adverse Drug Reactions Induced by TCM Injections", Asia Pacific Traditional Medicine, 12(9), pp.145~147 (2016)
- Wu JY, "Causes of Adverse Reaction of Injection of Chinese Medicines in our Hospital", Strait Pharmaceutical Journal, 26(10), pp.156~157 (2014)
- Qian Q, "Causes and Preventive Measures of Injection of Chinese Medicines", China Medicine and Pharmacy, 4(18), pp.79~81 (2014)
- Sun CJ, "Reasons analysis and evaluation of 93cases of adverse drug reaction in-ducedby traditional Chinese medicine injection", China Medical Herald, 10(36), pp.106~109 (2013)
- Xie X, "Causes of adverse reactions caused by injection of traditional Chinese medicine", Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 22(6), pp.492~493 (2012)
- Wu H, "Common Causes of Adverse Injection of Chinese Medicines", Contemporary Medicine, 17(19), pp.146~147 (2011)
- Chen HS, "Causes of Adverse Reaction of Chinese Medicines Injection and Preventive Measuresapply", Guide of China Medicine, 8(13), pp.44~45 (2010)
- Wen W, "Advances in Studies on Anaphylactoid Reactions of Traditional Chinese Medicine Injections", Journal of Traditional Chinese Medicine University of Hunan, 40(1), pp.117~122 (2020)
- Jiang K, "Analysis and consideration of Adverse drug reaction in Traditional Chinese Medicine Injection", Modern Medicine Journal of China, 23(04), pp.93~98 (2021)
- Wu QG, "The Current Situation and Outlet of Traditional Chinese Medicine Injection", Chinese and Foreign Medical Research, 17(36), pp.185~188 (2019)[DOI]
- Zhao XX, "Studies of Chinese herbal injections" (2011), Guangdong Science and Technology Press
- Zhang BS., "Chinese Medicine Pharmacy", pp.166~167 (2013), China Medical Science Press
- Zeng CY, "Causes for Adverse Reactions of Traditional Chinese Medicine Injections : A Case Study of the"Houttuynia Cordata Injection Event"", China Pharmacy, 18(6), pp.401~403 (2007)[DOI]
- Wu X, "Beware of serious adverse drug reaction from Qingkailing injection", China Licensed Pharmacist, 6(5), pp.22~23 (2009)
- Xie XS, "Evaluation on safety of puerarin injection in clinical use", China Journal of Chinese Materia Medica, 43(19), pp.3956~3961 (2018)
- Patton K, "Adverse drug reactions", Anaesthesia, 73, pp.76~84 (2018)
- Ruiter R, "et al. Adverse drug reaction-related hospitalizations in persons aged 55 years and over", Drug&Aging, 29(3), pp.225~232 (2012)[DOI]
- Wang P, "Analysis on the health standard of Huangdi Neijing", China Journal of Traditional Chinese Medicine and Pharmacy, 36(1), pp.17~21 (2021)
- Qian Q., "ADR induced by chinese medicine injections:causes and counter measures", China Medicine and Pharmacy, (18), pp.79~81 (2014)[DOI]
- "71. Notice on Further Strengthening the production and clinical use management of traditional Chinese medicine injections. China: FGWJ-2009-10453" (2008)[URL]
- "In the nearly 400 billion retail pharmacy market, the three major categories of proprietary Chinese medicines have performed well, and the development of this category will be hindered!"[URL]
- Zhang Q, "Progress of Clinical Application of Xuexuantong Injection", Hunan Guiding Journal of TCM, 10(4), pp.63~64 (2004)[DOI]
- Liu WW, "Analysis of characteristics of adverse drug reactions of Xueshuantong for injection(freeze-dried)in clinical application and reference study on clinical medication", Clinical Research and Practice, 5(25), pp.127~129 (2020)[DOI]
- Fu YX, "Summary of Research on Adverse Reactions", Events of Traditional Chinese Medicine Injections for Clearing Heat and Detoxification, 2021, pp.43(03), 521~524
- Bettina Wedi, "Definitions and mechanisms of drug hypersensitivity", 3(04), pp.539~551 (2010)[DOI]
- Dean D. Metcalfe, "Mechanisms of mast cell signaling in anaphylaxis", J Allergy Clin Immunol, 10, pp.636~639 (2009)[DOI]
- 하희정, "국내에서 연구된 항염 효능이 있는 한약재의 본초학적 분석", 대한본초학회지, 26(4), pp.15~22 (2011), 대한본초학회
- Wang JS, "Current Situation and Development Trends of Production Processes of Traditional Chinese Medicine Injection", Dazhong Keji, 23(01), pp.65~67 (2021)
- Lei ZH, "The Causes of Adverse Reaction in Traditional Chinese Medicine Injection", Journal of Clinical Medical Literature(Electronic Edition), 5(74), pp.81~82 (2018)[DOI]
- Sorkin EM. Clissold SP, "Nifedipine", Drugs, 30, pp.182~274 (1985)[DOI]
- Li XD, "Causes and Preventive Measures of Adverse Drug Reaction in Traditional Chinese Medicine Injection", Chinese Journal of Clinical Rational Drug Use, 13(22), pp.80~81 (2020)[DOI]
- Xie X, "Analysis of adverse drug reaction caused by Traditional Chinese Medicine Injection", Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 22(6), pp.492~493 (2012)[DOI]
- Qin FR, "Common problems and countermeasures in the clinical application of Traditional Chinese Medicine injections", Practical Journal of Medicine & Pharmacy, 25(1), pp.51~52 (2008)[DOI]
- Zeng BL, "Study on Adverse Reaction of Chinese Medicinal Injection and Countermeasures", Lishizhen Medicine and Materia Medica Research, 21(3), pp.757~759 (2010)[DOI]
- Zhang T, "Analysis of 149 cases of Chinese medicine injection in our hospital", Chinese Journal of Ethnomedicine and Ethnopharmacy, 28(10), pp.126~131 (2019)
- Tang ZS, "A review of causes and preventive countermeasures about 127Cases of adverse drug reactions in Traditional Chinese Medicine injection", Heilongjiang Medicine Journal, 30(6), pp.1237~1239 (2017)[DOI]
- Wen Q, "The Causes and Preventive Solution of Adverse Drug Reaction in Traditional Chinese Medicine Injections", Chinese Journal of Ethnomedicine and Ethnopharmacy, 25(17), pp.79~80 (2016)
