인지장애에 대한 기공요법의 유효성에 관한 서술적 문헌 고찰: 신경영상 연구를 중심으로
A Narrative Literature Review on the Effectiveness of Qigong Therapy for Cognitive Impairment: Focusing on the Neuroimaging Studies
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초록
The purpose of this study was to investigate the current state of clinical studies of qigong therapies for cognitive impairment using neuroimaging method. We searched for clinical trials of qigong therapies for cognitive impairment using neuroimaging method in the MEDLINE (Pubmed) and CNKI on October 18, 2024. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of qigong therapies in cognitive impairment. Total six studies were included in this study. The most frequently utilized modality was functional MRI. The qigong therapies applied in the study were Tai chi and Baduanjin. Looking at the selected studies, there were many cases that the control group included controls who did not perform any interventions other than health education and an active control group that performed brisk walking. It was confirmed that Qigong therapy can improve cognitive function more broadly, including MoCA scores, compared to the general control group or walking group. Moreover, several studies revealed that qigong therapies could regulate brain activation centered on medial temporal lobe, frontal areas, parietal lobes, attention-related brain networks, and brainstem including neurotransmitter-related nuclei. Through the analysis, we demonstrated that neuroimaging techniques could explore the neural mechanisms of qigong therapies on cognitive impairment. We hope that this perspective on the effectiveness of qigong therapy using neuroimaging methods would be helpful in performing future clinical researches on the mechanisms of Alzheimer's disease in the traditional Korean medicine.
Abstract
The purpose of this study was to investigate the current state of clinical studies of qigong therapies for cognitive impairment using neuroimaging method. We searched for clinical trials of qigong therapies for cognitive impairment using neuroimaging method in the MEDLINE (Pubmed) and CNKI on October 18, 2024. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of qigong therapies in cognitive impairment. Total six studies were included in this study. The most frequently utilized modality was functional MRI. The qigong therapies applied in the study were Tai chi and Baduanjin. Looking at the selected studies, there were many cases that the control group included controls who did not perform any interventions other than health education and an active control group that performed brisk walking. It was confirmed that Qigong therapy can improve cognitive function more broadly, including MoCA scores, compared to the general control group or walking group. Moreover, several studies revealed that qigong therapies could regulate brain activation centered on medial temporal lobe, frontal areas, parietal lobes, attention-related brain networks, and brainstem including neurotransmitter-related nuclei. Through the analysis, we demonstrated that neuroimaging techniques could explore the neural mechanisms of qigong therapies on cognitive impairment. We hope that this perspective on the effectiveness of qigong therapy using neuroimaging methods would be helpful in performing future clinical researches on the mechanisms of Alzheimer's disease in the traditional Korean medicine.
참고문헌 (40)
- Liew TM, "Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia", Alzheimers Res Ther, 12(1), pp.135~ (2020)
- Jak AJ, "Quantification of five neuropsychological approaches to defining mild cognitive impairment", Am J Geriatr Psychiatry, 17(5), pp.368~375 (2009)
- Smid J, "Subjective cognitive decline, mild cognitive impairment, and dementia-syndromic approach : recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology", Dement Neuropsychol, 16(3 Suppl 1), pp.1~24 (2022)
- Roberts R, "Classification and epidemiology of MCI", Clin Geriatr Med, 29(4), pp.753~772 (2013)
- Xue C, "AI-based differential diagnosis of dementia etiologies on multimodal data", Nat Med, 30(10), pp.2977~2989 (2024)
- Wimo A, "The worldwide costs of dementia in 2019", Alzheimers Dement, 19(7), pp.2865~2873 (2023)
- Jack CR Jr, "NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease", Alzheimers Dement, 14(4), pp.535~562 (2018)
- van Dyck CH, "Lecanemab in Early Alzheimer's Disease", N Engl J Med, 388(1), pp.9~21 (2023)
- Wang LY, "Overview of Meta-Analyses of Five Non-pharmacological Interventions for Alzheimer's Disease", Front Aging Neurosci, 12, pp.594432~ (2020)
- Li X, "Non-drug Therapies for Alzheimer's Disease : A Review", Neurol Ther, 12(1), pp.39~72 (2023)
- Li F, "Tai chi and postural stability in patients with Parkinson's disease", N Engl J Med, 366(6), pp.511~519 (2012)
- Tao J, "Tai Chi Chuan and Baduanjin Increase Grey Matter Volume in Older Adults : A Brain Imaging Study", J Alzheimers Dis, 60(2), pp.389~400 (2017)
- Dong X, "The Effects of Qigong for Hypertension : A Meta-Analysis of Randomized Controlled Trials", Evid Based Complement Alternat Med, 2021, pp.5622631~ (2021)
- Meng D, "The Effects of Qigong on Type 2 Diabetes Mellitus : A Systematic Review and Meta-Analysis", Evid Based Complement Alternat Med, 2018, pp.8182938~ (2018)
- Tsang HW, "Psycho-physical and neurophysiological effects of qigong on depressed elders with chronic illness", Aging Ment Health, 17(3), pp.336~348 (2013)
- Li B, "Tai Chi enhances cognitive training effects on delaying cognitive decline in mild cognitive impairment", Alzheimers Dement, 19(1), pp.136~149 (2023)
- Tao J, "Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment", Neuroimage Clin, 23, pp.101834~ (2019)
- Xia R, "The Effect of Traditional Chinese Mind-Body Exercise (Baduanjin) and Brisk Walking on the Dorsal Attention Network in Older Adults With Mild Cognitive Impairment", Front Psychol, 10, pp.2075~ (2019)
- Zheng G, "Traditional Chinese Mind-Body Exercise Baduanjin Modulate Gray Matter and Cognitive Function in Older Adults with Mild Cognitive Impairment : A Brain Imaging Study", Brain Plast, 7(2), pp.131~142 (2021)
- Liu J, "Mind-Body Exercise Modulates Locus Coeruleus and Ventral Tegmental Area Functional Connectivity in Individuals With Mild Cognitive Impairment", Front Aging Neurosci, 13, pp.646807~ (2021)
- Lin M, "Tai Chi-Induced Exosomal LRP1 is Associated With Memory Function and Hippocampus Plasticity in aMCI Patients", Am J Geriatr Psychiatry, 32(10), pp.1215~1230 (2024)
- Serrano-Pozo A, "Neuropathological alterations in Alzheimer disease", Cold Spring Harb Perspect Med, 1(1), pp.a006189~ (2011)
- Jack CR Jr, "Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade", Lancet Neurol, 9(1), pp.119~128 (2010)
- Agarwal A, "Amyloid-related Imaging Abnormalities in Alzheimer Disease Treated with Anti-Amyloid-β Therapy", Radiographics, 43(9), pp.e230009~ (2023)
- Oh B, "Effects of qigong on depression : a systemic review", Evid Based Complement Alternat Med, 2013, pp.134737~ (2013)
- Wan Z, "Effects of Health Qigong Exercises on Physical Function on Patients with Parkinson's Disease", J Multidiscip Healthc, 14, pp.941~950 (2021)
- Wang X, "Effect of Baduanjin exercise on the cognitive function of middle-aged and older adults : A systematic review and meta-analysis", Complement Ther Med, 59, pp.102727~ (2021)
- Logothetis NK, "The underpinnings of the BOLD functional magnetic resonance imaging signal", J Neurosci, 23(10), pp.3963~3971 (2003)
- Yang B, "The altered spontaneous neural activity in patients with Parkinson's disease and its predictive value for the motor improvement of deep brain stimulation", Neuroimage Clin, 38, pp.103430~ (2023)
- Yang F, "A Study of Spontaneous Brain Activity on Resting-State Functional Magnetic Resonance Imaging in Adults with MRI-Negative Temporal Lobe Epilepsy", Neuropsychiatr Dis Treat, 18, pp.1107~1116 (2022)
- Li MT, "The effect of seed location on functional connectivity : evidence from an image-based meta-analysis", Front Neurosci, 17, pp.1120741~ (2023)
- Ratcliffe LN, "Classification statistics of the Montreal Cognitive Assessment(MoCA) : Are we interpreting the MoCA correctly?", Clin Neuropsychol, 37(3), pp.562~576 (2023)
- Rauch JN, "LRP1 is a master regulator of tau uptake and spread", Nature, 580(7803), pp.381~385 (2020)
- Hwnag EY, "Comparative review of qigong and daoyin as a therapeutic exercise of traditional korean medicine", Journal of Physiology & Pathology in Korean Medicine, 27(5), pp.594~601 (2013)
- "Korean Society of Chuna Manual Medicine Spine and Nerves", 2020, 9~18
- Sung SH, "Analysis of Current Status of Qigong Training Organizations focusing on Javaldonggong", Journal of Haehwa Medicine, 22(2), pp.47~56 (2014)
- Preventive Korean medicine textbook compilation committee, "Korean Preventive Medicine", pp.39~59 (2012), Gyechuk
- Kim TY, "A Review Study on Qigong Interventions for Performance Enhancement in Korean Journal Articles : A Preliminary Study for Developing Qigong Therapy for Elite Athletes", Journal of Oriental Neuropsychiatry, 30(1), pp.13~21 (2019)
- Kim YS, "A study on effects of Tai chi training from the viewpoint of oriental medicine", Journal of Sports Korean Medicine & Clinical Pharmacoacupuncture, 5(1), pp.88~92 (2004)
- Lee YT, "The study on the principle and training of ‘PAL DAN GUM’", Journal of Dong-Eui Oriental Medicine, 9(1), pp.65~82 (1997)