Diagnostic Efficacy of Endoscopic Ultrasound Elastography in Differentiating Solid Pancreatic Lesions: A Single-Center Experience
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Background/Aims: Endoscopic ultrasound (EUS) has a limited ability to determine the nature of solid pancreatic lesions (SPLs). Mostrecent ultrasound processors are provided with elastography software, which allows quantification of the tissue hardness. The aim ofthis study is to evaluate the effectiveness of the elasticity score (ES) and strain ratio (SR) in the differentiation of benign pancreaticlesions from malignant pancreatic lesions. Methods: The study had a retrospective design; it included 97 patients with SPLs and 19 patients with inflammatory lesions. The ES andSR were determined during the examination; finally, EUS-guided fine needle aspiration was performed. Results: In this 2-year study, 116 patients were enrolled (97 with malignant lesions and 19 with benign lesions). There were 69 men and47 women. Their median age was 55.9 years. A cut-off point was detected at SR of 7.75 with a specificity of 99.9%, sensitivity of 90.7%,positive predictive value (PPV) of 99.9%, negative predictive value (NPV) of 67.9%, and accuracy of 92.2%. After adding the ES to theSR, the cut-off point at 7.75 resulted in a specificity of 94.6%, sensitivity of 99%, PPV of 98%, NPV of 98.5%, and accuracy of 97%. Conclusions: The use of the ES combined with the SR increases the accuracy of differentiation between benign and malignant SPLsand is an effective method for the evaluation of pancreatic masses.
Abstract
Background/Aims: Endoscopic ultrasound (EUS) has a limited ability to determine the nature of solid pancreatic lesions (SPLs). Mostrecent ultrasound processors are provided with elastography software, which allows quantification of the tissue hardness. The aim ofthis study is to evaluate the effectiveness of the elasticity score (ES) and strain ratio (SR) in the differentiation of benign pancreaticlesions from malignant pancreatic lesions. Methods: The study had a retrospective design; it included 97 patients with SPLs and 19 patients with inflammatory lesions. The ES andSR were determined during the examination; finally, EUS-guided fine needle aspiration was performed. Results: In this 2-year study, 116 patients were enrolled (97 with malignant lesions and 19 with benign lesions). There were 69 men and47 women. Their median age was 55.9 years. A cut-off point was detected at SR of 7.75 with a specificity of 99.9%, sensitivity of 90.7%,positive predictive value (PPV) of 99.9%, negative predictive value (NPV) of 67.9%, and accuracy of 92.2%. After adding the ES to theSR, the cut-off point at 7.75 resulted in a specificity of 94.6%, sensitivity of 99%, PPV of 98%, NPV of 98.5%, and accuracy of 97%. Conclusions: The use of the ES combined with the SR increases the accuracy of differentiation between benign and malignant SPLsand is an effective method for the evaluation of pancreatic masses.
참고문헌 (13)
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