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Endoscopic Management with a Novel Over-The-Scope Padlock Clip System

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초록

Background/Aims: The Padlock clip is a recently introduced over-the-scope clip (OTSC) that requires the use of an alternate techniqueand has a different design from previous OTSCs. However, data regarding its clinical use are limited. The aim of this study is to presentour clinical experience using this novel Padlock clip system. Methods: Between September 2018 and June 2019, 7 consecutive patients underwent Padlock clip application at our center by anexperienced endoscopist. A Padlock clip was used for achieving hemostasis in 4 patients presenting with gastrointestinal (GI) bleeding,as well as for endoscopic full-thickness resection in the remaining 3 patients. Results: All 7 patients achieved technical as well as clinical success, with absence of complications or rebleeding, during a follow-up ofa minimum of 3 weeks. All patients were hospitalized post procedure for a minimum of 48 hours, and an absence of adverse events wasnoted in our patient population throughout the procedure and post-procedure period. Antiplatelet therapy was reinstated shortly afterthe application of the Padlock clip, with no GI bleeding observed. Conclusions: The Padlock clip is a novel OTSC, with benefits that include safe, simple, and rapid deployment. Antiplatelet therapy maybe reinstated for patients, when necessary, shortly after applying the Padlock clip due to full-thickness closure of the tissue.

Abstract

Background/Aims: The Padlock clip is a recently introduced over-the-scope clip (OTSC) that requires the use of an alternate techniqueand has a different design from previous OTSCs. However, data regarding its clinical use are limited. The aim of this study is to presentour clinical experience using this novel Padlock clip system. Methods: Between September 2018 and June 2019, 7 consecutive patients underwent Padlock clip application at our center by anexperienced endoscopist. A Padlock clip was used for achieving hemostasis in 4 patients presenting with gastrointestinal (GI) bleeding,as well as for endoscopic full-thickness resection in the remaining 3 patients. Results: All 7 patients achieved technical as well as clinical success, with absence of complications or rebleeding, during a follow-up ofa minimum of 3 weeks. All patients were hospitalized post procedure for a minimum of 48 hours, and an absence of adverse events wasnoted in our patient population throughout the procedure and post-procedure period. Antiplatelet therapy was reinstated shortly afterthe application of the Padlock clip, with no GI bleeding observed. Conclusions: The Padlock clip is a novel OTSC, with benefits that include safe, simple, and rapid deployment. Antiplatelet therapy maybe reinstated for patients, when necessary, shortly after applying the Padlock clip due to full-thickness closure of the tissue.

참고문헌 (12)

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  2. Manta R, "Over-the-scope clip (OTSC)represents an effective endoscopic treatment for acute GI bleeding after failure of conventional techniques", Surg Endosc, 27, pp.3162~3164 (2013)
  3. Fahndrich M, "Endoscopic full-thickness resection for gastrointestinal lesions using the over-the-scope clip system: a case series", Endoscopy, 47, pp.76~79 (2015)
  4. Dinelli M, "First clinical experiences with a novel endoscopic over-the-scope clip system", Endosc Int Open, 5, pp.E151~E156 (2017)
  5. Mahesh Kumar Goenka, "Endoscopic Management of Gastrointestinal Leaks and Bleeding with the Over-the-Scope Clip: A Prospective Study", Clinical Endoscopy, 50(1), pp.58~63 (2017), 대한소화기내시경학회
  6. Chan SM, "Use of the over-the-scope clip for treatment of refractory upper gastrointestinal bleeding : a case series", Endoscopy, 46, pp.428~431 (2014)
  7. Armellini E, "Novel endoscopic over-the-scope clip system", World J Gastroenterol, 21, pp.13587~13592 (2015)
  8. Lamberts R, "Use of over-the-scope clips(OTSC)for hemostasis in gastrointestinal bleeding in patients under antithrombotic therapy", Endosc Int Open, 5, pp.E324~E330 (2017)
  9. Manta R, "First-line endoscopic treatment with over-the-scope clips in patients with either upper or lower gastrointestinal bleeding : a multicenter study", Endosc Int Open, 6, pp.E1317~E1321 (2018)
  10. Shiba M, "Risk factors for bleeding after endoscopic mucosal resection", World J Gastroenterol, 11, pp.7335~7339 (2005)
  11. Prosst RL, "A randomized comparative trial of OTSC and Padlock for upper GI hemostasis in a standardized experimental setting", Minim Invasive Ther Allied Technol, 26, pp.65~70 (2017)
  12. Al-Bawardy B, "Over-the-scope clip-assisted endoscopic full-thickness resection of epithelial and subepithelial GI lesions", Gastrointest Endosc, 85, pp.1087~1092 (2017)

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