Endoscopic Factors that Can Predict Histological Ulcerations in Early Gastric Cancers
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초록
Background/Aims: Predicting histological ulceration in early gastric cancer (EGC) during endoscopic examination is crucial forendoscopists deciding on the treatment modality. The aim of this study was to investigate the endoscopic factors that can predicthistological ulcerations in EGCs. Methods: We retrospectively analyzed patients who underwent endoscopic submucosal dissection (ESD) for EGC. Clinical features andendoscopic characteristics of EGC such as location, histological differentiation, longest diameter, tumor morphology, mucosal break,converging fold, color change, and surface irregularity were reviewed. Histological ulceration was defined based on ESD specimens. Results: A total of 633 EGC lesions from 613 patients were included and histological ulcerations were found in 90 lesions (14.2%). Presence of converging folds, tumor morphology, and color changes on endoscopic examination were related to histological ulcerationin the univariate analysis and converging folds along with color changes were statistically significant factors in the multivariate analysis. Kaplan–Meier analysis showed that patients with histological ulcerations in EGCs tended to have higher marginal recurrence rates. Conclusions: Mucosal breaks are not equivalent to histological ulcerations. Rather, the existence of converging folds and color changesduring endoscopic examination suggest histological ulcerations. Endoscopists should consider these factors when they decide thetreatment modality for EGCs.
Abstract
Background/Aims: Predicting histological ulceration in early gastric cancer (EGC) during endoscopic examination is crucial forendoscopists deciding on the treatment modality. The aim of this study was to investigate the endoscopic factors that can predicthistological ulcerations in EGCs. Methods: We retrospectively analyzed patients who underwent endoscopic submucosal dissection (ESD) for EGC. Clinical features andendoscopic characteristics of EGC such as location, histological differentiation, longest diameter, tumor morphology, mucosal break,converging fold, color change, and surface irregularity were reviewed. Histological ulceration was defined based on ESD specimens. Results: A total of 633 EGC lesions from 613 patients were included and histological ulcerations were found in 90 lesions (14.2%). Presence of converging folds, tumor morphology, and color changes on endoscopic examination were related to histological ulcerationin the univariate analysis and converging folds along with color changes were statistically significant factors in the multivariate analysis. Kaplan–Meier analysis showed that patients with histological ulcerations in EGCs tended to have higher marginal recurrence rates. Conclusions: Mucosal breaks are not equivalent to histological ulcerations. Rather, the existence of converging folds and color changesduring endoscopic examination suggest histological ulcerations. Endoscopists should consider these factors when they decide thetreatment modality for EGCs.
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