방광의 MALT 림프종 1예
A case of MALT lymphoma of the urinary bladder
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초록
방광 MALT 림프종은 만성 방광염과 감별이 어려운 드문 질환으로 아직 국내에는 보고 된 바 없다. 저자들은 치유되지 않는 만성 방광염 환자에서 방광 MALT 림프종을 조직학적으로 진단하였고 또한 PCR을 이용한 B 림프구의 단클론성을 입증함으로써 확진 하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Primary lymphoma of the urinary bladder is a rare non-epithelial bladder tumor accounting for less than 1% of all bladder tumors. Approximately 17 cases of MALT lymphomas of bladder have been reported in the literature. Most reported MALT lymphomas of bladder have a female sexual preponderance with a mean age of 58 years with common presenting symptoms of hematuria, dysuria and urinary frequency. The reported prognosis of MALT lymphoma of the urinary bladder is excellent. We report a case of MALT lymphoma of urinary bladder in a 57-year-old woman patient who presented with a two-year history of persistent dysuria and urinary frequency. An intravenous pyelogram and cystoscopy revealed a 1 cm focal elevated lesion at the base of urinary bladder. The tissue obtained by transurethral resection (TUR) showed plasma cell infiltration consistent with low grade marginal zone B cell lymphoma. The immunohistochemical studies showed an immunoglobulin restriction to lambda light chain while the nested polymerase chain reaction analysis of the tissue showed a monoclonal Ig heavy-chain gene rearrangement. The clinical staging protocol revealed that the tumor was primarily arising from the urinary bladder with no evidence of other site involvements. The patient received radiation therapy of 3060 cGy in 17 fractions.(Korean J Med 63:98-102, 2002)