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Current Status of Photodynamic Therapy for Bile Duct Cancer

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초록

The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially hilar cholangiocarcinoma, is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Although biliary endoprosthesis improves occlusion rates and reduces the number of therapeutic interventions, median survival time is not ameliorated. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent in combination with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time in selected patients with bile duct cancers.

Abstract

The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially hilar cholangiocarcinoma, is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Although biliary endoprosthesis improves occlusion rates and reduces the number of therapeutic interventions, median survival time is not ameliorated. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent in combination with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time in selected patients with bile duct cancers.

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관련 논문AI추천

Recent advances of photodynamic therapy for biliary tract cancerYoung Koog Cheon소화기인터벤션의학회 · International Journal of Gastrointestinal Intervention2021 · 제10권 제3호Photodynamic Therapy Plus Chemotherapy Compared with Photodynamic Therapy Alone in Hilar Nonresectable CholangiocarcinomaAndrey Mitroshkin, Carsten Büning, Christian Jürgensen, Guido Schachschal, Matthias Prager, Nicola Winkelmann, Robert Wentrup, Winfried Voderholzer거트앤리버 소화기연관학회협의회 · Gut and Liver2016 · 제10권 제3호Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma심찬섭, 이응준, 이태윤, 천영국, 홍미진거트앤리버 소화기연관학회협의회 · Gut and Liver2014 · 제8권 제3호Comparing palliative treatment options for cholangiocarcinoma: photodynamic therapy vs. radiofrequency ablationMichel Kahaleh, Tayyaba Mohammad대한소화기내시경학회 · Clinical Endoscopy2022 · 제55권 제3호Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?이한희, 최명규, Tayyaba Hasan대한내과학회 · The Korean Journal of Internal Medicine2017 · 제32권 제1호Comprehensive management of cholangiocarcinoma: Part II. TreatmentCharilaos Papafragkakis, Jeffrey H. Lee소화기인터벤션의학회 · International Journal of Gastrointestinal Intervention2017 · 제6권 제2호

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