급성 뇌경색증에서 급성기 반응 단백의 임상적 의의;후향적 연구

Abstract

Background : The acute phase response(APR), which includes elevation of C-reactive protein(CRP), fibrinogen(FIB), occurs following a wide variety of different forms of infection, inflammation, or tissue injury. But, it is not yet clear whether the elevation of CRP and FIB in acute cerebral infarction is associated with the acute phase response arising from post-infarction tissue injury and necrosis or cormorbid risk factors in stroke such as peristroke infection and smoking. Objective : To better understand the acute inflammatory response in cerebral infarction, we studied for the association between the level of acute phase markers (CRP, FIB) and stroke volume or stroke subtypes. Methods : 1) CRP and FIB were measured during the first 48hours after stroke onset on 75 acute ischemic stroke patients uncomplicated by infection. 2) The correlation between APR levels and stroke volume or stroke subtype was determined. Results : Large territorial infarction had higher base line CRP levels than focal infarction (mean 1.4303 ¡¾2.0779 mg/dl VS 0.3294 ¡¾0.6623 mg/dl, P=0.02). But, there was no significant correlation between the level of FIB and stroke volume. There was no significant relationship between the level of APR and stroke subtypes(TOAST classification). Conclusion : Our data shows significant correlation between infarction volume and serum CRP level. The data suggest that the acute inflammatory response may be involved in the process of cerebral infarction and the magnitude of this response may be related to the infarction size. Korean Journal of Stroke 2001;3(1): 67~70