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A Case of Midazolam Anaphylaxis

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초록

Midazolam is a type of anesthetic agent frequently used for conscious sedation during a variety of medical procedures. Anaphylactic reactions to midazolam are rarely reported. However, we observed a case of midazolam hypersensitivity in which emergency measures were required to ensure patient recovery after administration of midazolam as a sedative. The occurrence of the anaphylactic reaction to midazolam was confirmed by elevated serum tryptase levels. The current case report presents a discussion of our findings.

Abstract

Midazolam is a type of anesthetic agent frequently used for conscious sedation during a variety of medical procedures. Anaphylactic reactions to midazolam are rarely reported. However, we observed a case of midazolam hypersensitivity in which emergency measures were required to ensure patient recovery after administration of midazolam as a sedative. The occurrence of the anaphylactic reaction to midazolam was confirmed by elevated serum tryptase levels. The current case report presents a discussion of our findings.

참고문헌 (13)

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  3. 황진영, "Midazolam hypersensitivity during the transportation to theater -A case report-", Korean Journal of Anesthesiology, 59, pp.1~2 (2010), 대한마취통증의학회
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  8. Davis DP, "Reversal of midazolam-induced laryngospasm with flumazenil", Ann Emerg Med, 32, pp.263~265 (1998)
  9. Robb ND, "Epileptic fits under intravenous midazolam sedation", Br Dent J, 181, pp.178~179 (1996)
  10. Yates A, "A reaction to midazolam: a topical solution", Anaesthesia, 44, pp.449~ (1989)
  11. Rodrigo CR, "Cardiac dysrhythmias with midazolam sedation", Anesth Prog, 37, pp.20~23 (1990)
  12. Mertes PM, "Groupe d’Etudes des Réactions Anaphylactoïdes Peranesthésiques. Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000", Anesthesiology, 99, pp.536~545 (2003)
  13. Schwartz LB, "Diagnostic value of tryptase in anaphylaxis and mastocytosis", Immunol Allergy Clin North Am, 26, pp.451~463 (2006)

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