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Xanthoma of the Esophagus

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초록

Xanthoma is an uncommon nonneoplastic lesion resulting from the accumulation of histiocytes. It predominantly shows cutaneous manifestations associated with dyslipidemia. However, xanthoma of the esophagus is extremely rare. To the best of our knowledge, only 14 cases have been reported thus far. The clinical significance of this lesion has not been established. However, this lesion should be distinguished grossly from ectopic sebaceous glands and small subepithelial tumors such as carcinoid and granular cell tumor. Moreover, signet ring cell carcinoma, which contains round cells with abundant cytoplasm and has similar histologic features to xanthoma, should be distinguished microscopically.

Abstract

Xanthoma is an uncommon nonneoplastic lesion resulting from the accumulation of histiocytes. It predominantly shows cutaneous manifestations associated with dyslipidemia. However, xanthoma of the esophagus is extremely rare. To the best of our knowledge, only 14 cases have been reported thus far. The clinical significance of this lesion has not been established. However, this lesion should be distinguished grossly from ectopic sebaceous glands and small subepithelial tumors such as carcinoid and granular cell tumor. Moreover, signet ring cell carcinoma, which contains round cells with abundant cytoplasm and has similar histologic features to xanthoma, should be distinguished microscopically.

참고문헌 (14)

  1. Gencosmanoglu R, "Xanthelasmas of the upper gastrointestinal tract", J Gastroenterol, 39, pp.215~219 (2004)
  2. Remmele W, "Lipid island of the esophagus", Case report. Endoscopy, 16, pp.240~241 (1984)
  3. Stolte M, "Lipid islands in the esophagus", Leber Magen Darm, 15, pp.137~139 (1985)
  4. Vimala R, "Xanthelasma of esophagus and stomach", Indian J Gastroenterol, 19, pp.135~ (2000)
  5. Hirokawa M, "Esophageal xanthoma: report of two cases and a review of the literature", J Gastroenterol Hepatol, 18, pp.1105~1108 (2003)
  6. Cho DS, "An esophageal xanthoma diagnosed by upper gastrointestinal endoscopy", Korean J Med, 75(Suppl 3), pp.S784~S786 (2008)
  7. Arima M, "Esophageal xanthoma: report of two cases", Stomach Intest, 43, pp.317~320 (2008)
  8. Becheanu G, "Esophageal xanthoma: report of two new cases and review of the literature", J Gastrointestin Liver Dis, 20, pp.431~433 (2011)
  9. Park HS, "Incidental esophageal xanthoma in a patient with ileocecal lymphoma", Dig Endosc, 25, pp.92~93 (2013)
  10. Herrera-Goepfert R, "Verruciform xanthoma of the esophagus", Hum Pathol, 34, pp.814~815 (2003)
  11. Licci S, "Verruciform xanthoma of the esophagus: an uncommon entity in an unusual site", Endoscopy, 42(Suppl 2), pp.E330~ (2010)
  12. Min KW, "Verruciform xanthoma arising in the mid esophagus", Dig Endosc, 24, pp.387~ (2012)
  13. Salamanca J, "Esophageal verruciform xanthoma following radiotherapy", Gastroenterol Hepatol, 35, pp.317~320 (2012)
  14. Kim YS, "Esophageal ectopic sebaceous glands", Clin Gastroenterol Hepatol, 5, pp.A23~ (2007)

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