Colon Cancer Screening and Surveillance in Inflammatory Bowel Disease
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Accordingly, the duration and anatomic extent of the disease have been known to affect the development of IBD-related CRC. When CRC occurs in patients with IBD, unlike in sporadic CRC, it is difficult to detect the lesions because of mucosal changes caused by inflammation. In addition, the tumor types vary with ill-circumscribed lesions, and the cancer is difficult to diagnose and remedy at an early stage. For the diagnosis of CRC in patients with IBD, screening endoscopy is recommended 8 to 10 years after the IBD diagnosis, and surveillance colonoscopy is recommended every 1 to 2 years thereafter. The recent development of targeted biopsies using chromoendoscopy and relatively newer endoscopic techniques helps in the early diagnosis of CRC in patients with IBD. A total proctocolectomy is advisable when high-grade dysplasia or multifocal low-grade dysplasia is confirmed by screening endoscopy or surveillance colonoscopy or if a nonadenoma-like dysplasia-associated lesion or mass is detected. Currently, pharmacotherapies are being extensively studied as a way to prevent IBD-related CRC.
Abstract
Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Accordingly, the duration and anatomic extent of the disease have been known to affect the development of IBD-related CRC. When CRC occurs in patients with IBD, unlike in sporadic CRC, it is difficult to detect the lesions because of mucosal changes caused by inflammation. In addition, the tumor types vary with ill-circumscribed lesions, and the cancer is difficult to diagnose and remedy at an early stage. For the diagnosis of CRC in patients with IBD, screening endoscopy is recommended 8 to 10 years after the IBD diagnosis, and surveillance colonoscopy is recommended every 1 to 2 years thereafter. The recent development of targeted biopsies using chromoendoscopy and relatively newer endoscopic techniques helps in the early diagnosis of CRC in patients with IBD. A total proctocolectomy is advisable when high-grade dysplasia or multifocal low-grade dysplasia is confirmed by screening endoscopy or surveillance colonoscopy or if a nonadenoma-like dysplasia-associated lesion or mass is detected. Currently, pharmacotherapies are being extensively studied as a way to prevent IBD-related CRC.
참고문헌 (76)
- Amarender Singh Puri, "Epidemiology of Ulcerative Colitis in South Asia", Intestinal research, 11(4), pp.250~255 (2013), 대한장연구학회
- Rhodes JM, "Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared", Trends Mol Med, 8, pp.10~16 (2002)
- Farraye FA, "AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease", Gastroenterology, 138, pp.746~774 (2010)
- Mattar MC, "Current management of inflammatory bowel disease and colorectal cancer", Gastrointest Cancer Res, 4, pp.53~61 (2011)
- Eaden JA, "The risk of colorectal cancer in ulcerative colitis: a meta-analysis", Gut, 48, pp.526~535 (2001)
- Rutter MD, "Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis", Gastroenterology, 130, pp.1030~1038 (2006)
- Velayos FS, "Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies", Am J Gastroenterol, 100, pp.1345~1353 (2005)
- Kim BJ, "Trends of ulcerative colitis-associated colorectal cancer in Korea: A KASID study", J Gastroenterol Hepatol, 24, pp.667~671 (2009)
- Itzkowitz SH, "Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation", Am J Physiol Gastrointest Liver Physiol, 287, pp.G7~G17 (2004)
- Rutter M, "Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis", Gastroenterology, 126, pp.451~459 (2004)
- Ekbom A, "Ulcerative colitis and colorectal cancer. A population-based study", N Engl J Med, 323, pp.1228~1233 (1990)
- 김은영, "A Case of Cholangiocarcinoma and Colorectal Cancer Diagnosed Simultaneously in a Patient with Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis", Intestinal research, 10(4), pp.392~396 (2012), 대한장연구학회
- Kornfeld D, "Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study", Gut, 41, pp.522~525 (1997)
- Soetikno RM, "Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis", Gastrointest Endosc, 56, pp.48~54 (2002)
- Broomé U, "Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer", Semin Liver Dis, 26, pp.31~41 (2006)
- Delaunoit T, "Colorectal cancer prognosis among patients with inflammatory bowel disease", Clin Gastroenterol Hepatol, 4, pp.335~342 (2006)
- Xie J, "Cancer in inflammatory bowel disease", World J Gastroenterol, 14, pp.378~389 (2008)
- Peyrin-Biroulet L, "Colorectal cancer in inflammatory bowel diseases: a population-based study (1976-2008)", Inflamm Bowel Dis, 18, pp.2247~2251 (2012)
- Jensen AB, "Survival after colorectal cancer in patients with ulcerative colitis: a nationwide population-based Danish study", Am J Gastroenterol, 101, pp.1283~1287 (2006)
- Larsen M, "Survival after colorectal cancer in patients with Crohn’s disease: a nationwide population-based Danish follow-up study", Am J Gastroenterol, 102, pp.163~167 (2007)
- Shu X, "Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden", Inflamm Bowel Dis, 17, pp.816~822 (2011)
- Herrinton LJ, "Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010", Gastroenterology, 143, pp.382~389 (2012)
- Collins PD, "Strategies for detecting colon cancer and", or dysplasia in patients with inflammatory bowel disease, 2006, pp.(2), CD000279~
- Lutgens MW, "Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease", Br J Cancer, 101, pp.1671~1675 (2009)
- Farraye FA, "AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease", Gastroenterology, 138, pp.738~745 (2010)
- Kornbluth A, "Ulcerative colitis practice guidelines in adults. American College of Gastroenterology, Practice Parameters Committee", Am J Gastroenterol, 92, pp.204~211 (1997)
- Leighton JA, "ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease", Gastrointest Endosc, 63, pp.558~565 (2006)
- Eaden JA, "British Society for Gastroenterology; Association of Coloproctology for Great Britain and Ireland. Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease", Gut, 51(Suppl 5), pp.V10~V12 (2002)
- Cairns SR, "Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)", Gut, 59, pp.666~689 (2010)
- Itzkowitz SH, "Consensus conference: colorectal cancer screening and surveillance in inflammatory bowel disease", Inflamm Bowel Dis, 11, pp.314~321 (2005)
- Kornbluth A, "Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee", Am J Gastroenterol, 99, pp.1371~1385 (2004)
- Biancone L, "European evidence-based consensus on the management of ulcerative colitis: special situations", J Crohns Colitis, 2, pp.63~92 (2008)
- Ye BD, "Clinical characteristics of ulcerative colitis associated with primary sclerosing cholangitis in Korea", Inflamm Bowel Dis, 17, pp.1901~1906 (2011)
- Aarnio M, "Prognosis of colorectal cancer varies in different high-risk conditions", Ann Med, 30, pp.75~80 (1998)
- Sugita A, "Survival with colorectal cancer in ulcerative colitis. A study of 102 cases", Ann Surg, 218, pp.189~195 (1993)
- Itzkowitz SH, "Diagnosis and management of dysplasia in patients with inflammatory bowel diseases", Gastroenterology, 126, pp.1634~1648 (2004)
- Hurlstone DP, "Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation", Endoscopy, 37, pp.1186~1192 (2005)
- Kiesslich R, "Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis", Gastroenterology, 124, pp.880~888 (2003)
- Kiesslich R, "Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis", Gastroenterology, 132, pp.874~882 (2007)
- Marion JF, "Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial", Am J Gastroenterol, 103, pp.2342~2349 (2008)
- Rutter MD, "Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis", Gut, 53, pp.256~260 (2004)
- Hurlstone DP, "Confocal chromoscopic endomicroscopy is superior to chromoscopy alone for the detection and characterisation of intraepithelial neoplasia in chronic ulcerative colitis", Gut, 57, pp.196~204 (2008)
- Riddell RH, "Grading of dysplasia", Eur J Cancer, 31A, pp.1169~1170 (1995)
- Blackstone MO, "Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy", Gastroenterology, 80, pp.366~374 (1981)
- Ullman T, "Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis", Gastroenterology, 125, pp.1311~1319 (2003)
- Befrits R, "Low-grade dysplasia in extensive, long-standing inflammatory bowel disease: a follow-up study", Dis Colon Rectum, 45, pp.615~620 (2002)
- Odze RD, "Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis", Clin Gastroenterol Hepatol, 2, pp.534~541 (2004)
- Riddell RH, "Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications", Hum Pathol, 14, pp.931~968 (1983)
- Torres C, "Polypoid dysplasia and adenomas in inflammatory bowel disease: a clinical, pathologic, and follow-up study of 89 polyps from 59 patients", Am J Surg Pathol, 22, pp.275~284 (1998)
- Farraye FA, "Variability in the diagnosis and management of adenoma-like and non-adenoma-like dysplasia-associated lesions or masses in inflammatory bowel disease: an Internet-based study", Gastrointest Endosc, 66, pp.519~529 (2007)
- Rutter MD, "Most dysplasia in ulcerative colitis is visible at colonoscopy", Gastrointest Endosc, 60, pp.334~339 (2004)
- Stolfi C, "Molecular basis of the potential of mesalazine to prevent colorectal cancer", World J Gastroenterol, 14, pp.4434~4439 (2008)
- Allgayer H, "Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease", Aliment Pharmacol Ther, 18(Suppl 2), pp.10~14 (2003)
- Lyakhovich A, "Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine", Aliment Pharmacol Ther, 31, pp.202~209 (2010)
- Moody GA, "Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire", Eur J Gastroenterol Hepatol, 8, pp.1179~1183 (1996)
- Pinczowski D, "Risk factors for colorectal cancer in patients with ulcerative colitis: a case-control study", Gastroenterology, 107, pp.117~120 (1994)
- Nguyen GC, "5-aminosalicylic acid is not protective against colorectal cancer in inflammatory bowel disease: a meta-analysis of non-referral populations", Am J Gastroenterol, 107, pp.1298~1304 (2012)
- van Staa TP, "5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study", Gut, 54, pp.1573~1578 (2005)
- Eaden J, "Colorectal cancer prevention in ulcerative colitis: a case-control study", Aliment Pharmacol Ther, 14, pp.145~153 (2000)
- Ullman T, "Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine", Clin Gastroenterol Hepatol, 6, pp.1225~1230 (2008)
- Terdiman JP, "5-Aminosalicylic acid therapy and the risk of colorectal cancer among patients with inflammatory bowel disease", Inflamm Bowel Dis, 13, pp.367~371 (2007)
- Bernstein CN, "Does the use of 5-aminosalicylates in inflammatory bowel disease prevent the development of colorectal cancer?", Am J Gastroenterol, 98, pp.2784~2788 (2003)
- 최창환, "궤양성 대장염 치료 가이드라인", Intestinal research, 10(1), pp.1~25 (2012), 대한장연구학회
- Sebastian S, "Colorectal cancer in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (I)", J Crohns Colitis, 8, pp.5~18 (2014)
- Shetty K, "The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis", Am J Gastroenterol, 94, pp.1643~1649 (1999)
- Hansen JD, "Ursodiol and colorectal cancer or dysplasia risk in primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis", Dig Dis Sci, 58, pp.3079~3087 (2013)
- Matula S, "Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine", Clin Gastroenterol Hepatol, 3, pp.1015~1021 (2005)
- Lashner BA, "Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study", Gastroenterology, 97, pp.255~259 (1989)
- Actis GC, "The 17-year single-center experience with the use of azathioprine to maintain remission in ulcerative colitis", Biomed Pharmacother, 63, pp.362~365 (2009)
- Actis GC, "Azathioprine, mucosal healing in ulcerative colitis, and the chemoprevention of colitic cancer: a clinical-practice-based forecast", Inflamm Allergy Drug Targets, 9, pp.6~9 (2010)
- Baars JE, "The risk of inflammatory bowel disease-related colorectal carcinoma is limited: results from a nationwide nested case-control study", Am J Gastroenterol, 106, pp.319~328 (2011)
- Kandiel A, "Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine", Gut, 54, pp.1121~1125 (2005)
- Kim YJ, "Prevention of colitis-associated carcinogenesis with infliximab", Cancer Prev Res (Phila), 3, pp.1314~1333 (2010)
- Lashner BA, "Brzezinski A. The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis", Gastroenterology, 112, pp.29~32 (1997)
- Biasco G, "Folic acid supplementation and cell kinetics of rectal mucosa in patients with ulcerative colitis", Cancer Epidemiol Biomarkers Prev, 6, pp.469~471 (1997)
- Poynter JN, "Statins and the risk of colorectal cancer", N Engl J Med, 352, pp.2184~2192 (2005)
