만성 호중구성 백혈병 1예
A case of chronic neutrophilic leukemia
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초록
CNL은 매우 드문 골수증식성 질환이며, 이의 진단 및 치료에 대해 많은 경험이 필요할 것으로 생각된다. 이에 저자들은 WHO 진단기준에 맞는 전형적인 CNL 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by clonal proliferation of mature neutrophils, hepatosplenomegaly, elevated leukocyte alkaline phosphatase score (ALP score) and a negative Philadelphia chromosome. To date, approximately 150 cases have been reported in the literature, including some cases presenting with a ‘leukemic’ state reflected by a neutrophilic reaction. The term ‘true’ CNL, recently introduced by Reilly, highlights the need for more experience with CNL cases to improve the diagnostic criteria. In Korea, about 10 cases have been reported in the literature and some of those cases did not meet the WHO diagnostic criteria for CNL. We present a typical case of CNL in a 66-year-old man who complained of general weakness and weight loss. On admission, the white blood cell count from the peripheral blood was 175,600/L with 80% segmented neutrophils. The cytogenic study was negative for the Philadelphia chromosome and had a normal karyotype.(Korean J Med 71:328-332, 2006)
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