Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find biomarkers. Most metabolome-related ischemic stroke studies were done in Asia and had exploratory designs. Although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: Excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; Oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and Stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. The discovered metabolite-stroke associations need further evaluation in prospective, high-quality studies with patients matched for age, risk factors, and medications.
Abstract
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find biomarkers. Most metabolome-related ischemic stroke studies were done in Asia and had exploratory designs. Although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: Excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; Oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and Stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. The discovered metabolite-stroke associations need further evaluation in prospective, high-quality studies with patients matched for age, risk factors, and medications.
참고문헌 (85)
- Powers WJ, "2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2018, pp.49, e46~e110
- Tsai CF, "Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review", Neurology, 81, pp.264~272 (2013)
- Nogueira RG, "Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct", N Engl J Med, 378, pp.11~21 (2018)
- Albers GW, "Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging", N Engl J Med, 378, pp.708~718 (2018)
- Lansberg MG, "Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis", Stroke, 40, pp.2438~2441 (2009)
- Connolly SJ, "Dabigatran versus warfarin in patients with atrial fibrillation", N Engl J Med, 361, pp.1139~1151 (2009)
- Shah SH, "Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function", Circulation, 126, pp.1110~1120 (2012)
- Honig RE, "Mass spectroscopy as an analytical tool", Ann N Y Acad Sci, 137, pp.262~283 (1966)
- Issaq HJ, "Utility of separation science in metabolomic studies", J Sep Sci, 31, pp.1936~1947 (2008)
- Lindon JC, "Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics", Annu Rev Anal Chem, 1, pp.45~69 (2008)
- Kind T, "FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography", mass spectrometry, 2009, pp.81, 10038~10048
- Bain JR, "Metabolomics applied to diabetes research: moving from information to knowledge", Diabetes, 58, pp.2429~2443 (2009)
- Want EJ, "From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics", J Proteome Res, 6, pp.459~468 (2007)
- A J, "Extraction and GC", MS analysis of the human blood plasma metabolome, 2005, pp.77, 8086~8094
- Rothman SM, "Glutamate and the pathophysiology of hypoxic: ischemic brain damage", Ann Neurol, 19, pp.105~111 (1986)
- Lai TW, "Excitotoxicity and stroke: identifying novel targets for neuroprotection", Prog Neurobiol, 115, pp.157~188 (2014)
- Fukuyama N, "Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the periinfarct region", J Cereb Blood Flow Metab, 18, pp.123~129 (1998)
- Pacher P, "Nitric oxide and peroxynitrite in health and disease", Physiol Rev, 87, pp.315~424 (2007)
- Chamorro Á, "The immunology of acute stroke", Nat Rev Neurol, 8, pp.401~410 (2012)
- Chamorro Á, "Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation", Lancet Neurol, 15, pp.869~881 (2016)
- Liu M, "Potential of serum metabolites for diagnosing post-stroke cognitive impairment", Mol Biosyst, 11, pp.3287~3296 (2015)
- Schousboe A, "Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission", Neurochem Res, 28, pp.347~352 (2003)
- Jung JY, "1H-NMR-based metabolomics study of cerebral infarction", Stroke, 42, pp.1282~1288 (2011)
- Ding X, "A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD)", Metab Brain Dis, 31, pp.279~287 (2016)
- Coster J, "Glutamine: metabolism and application in nutrition support", Asia Pac J Clin Nutr, 13, pp.25~31 (2004)
- Fonteh AN, "Free amino acid and dipeptide changes in the body fluids from Alzheimer’s disease subjects", Amino Acids, 32, pp.213~224 (2007)
- Kagiyama T, "Neuroprotective action of halogenated derivatives of L-phenylalanine", Stroke, 35, pp.1192~1196 (2004)
- Gao J, "Analysis of serum metabolites for the discovery of amino acid biomarkers and the effect of galangin on cerebral ischemia", Mol Biosyst, 9, pp.2311~2321 (2013)
- Allen CL, "Oxidative stress and its role in the pathogenesis of ischaemic stroke", Int J Stroke, 4, pp.461~470 (2009)
- Beckman JS, "Oxidative damage and tyrosine nitration from peroxynitrite", Chem Res Toxicol, 9, pp.836~844 (1996)
- Becker BF, "Towards the physiological function of uric acid", Free Radic Biol Med, 14, pp.615~631 (1993)
- Amaro S, "Uric acid administration in patients with acute stroke: a novel approach to neuroprotection", Expert Rev Neurother, 8, pp.259~270 (2008)
- Aad G, "Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC", Phys Rev Lett, 105, pp.161801~ (2010)
- Onetti Y, "Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment", Am J Physiol Heart Circ Physiol, 308, pp.H862~H874 (2015)
- Kelly PJ, "Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study", Stroke, 39, pp.100~104 (2008)
- Asahi M, "Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats", J Cereb Blood Flow Metab, 20, pp.452~457 (2000)
- Jian Liu K, "Matrix metalloproteinases and free radicals in cerebral ischemia", Free Radic Biol Med, 39, pp.71~80 (2005)
- Huang Y, "Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?", Cardiovasc Res, 90, pp.220~223 (2011)
- Sun N, "Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets", Transl Stroke Res, 7, pp.420~438 (2016)
- Prager B, "Sphingosine 1-phosphate signaling at the blood-brain barrier", Trends Mol Med, 21, pp.354~363 (2015)
- Testai FD, "Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia", J Neurochem, 131, pp.530~540 (2014)
- Homocysteine Studies Collaboration, "Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis", JAMA, 288, pp.2015~2022 (2002)
- Jung J, "1H NMR-based metabolic profiling of naproxen-induced toxicity in rats", Toxicol Lett, 200, pp.1~7 (2011)
- El Kossi MM, "Oxidative stress in the context of acute cerebrovascular stroke", Stroke, 31, pp.1889~1892 (2000)
- Zhang F, "Superoxide-dependent cerebrovascular effects of homocysteine", Am J Physiol, 274, pp.R1704~R1711 (1998)
- Howard VJ, "Changes in plasma homocyst(e)ine in the acute phase after stroke", Stroke, 33, pp.473~478 (2002)
- Dayal S, "Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia", Am J Physiol Heart Circ Physiol, 295, pp.H816~H825 (2008)
- Sacco RL, "Homocysteine as a risk factor for ischemic stroke: an epidemiological story in evolution", Neuroepidemiology, 17, pp.167~173 (1998)
- Lonn E, "Homocysteine lowering with folic acid and B vitamins in vascular disease", N Engl J Med, 354, pp.1567~1577 (2006)
- Jiang Z, "A metabonomic approach applied to predict patients with cerebral infarction", Talanta, 84, pp.298~304 (2011)
- Omenn GS, "Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database", Proteomics, 5, pp.3226~3245 (2005)
- Mamatha SN, "Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in Indian population", Clin Chim Acta, 412, pp.139~142 (2011)
- Wang Y, "Dynamic metabolites profile of cerebral ischemia", reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers, 2014, pp.7, 4067~4075
- Whitfield JB, "Gamma glutamyl transferase", Crit Rev Clin Lab Sci, 38, pp.263~355 (2001)
- D’Ambrosio D, "Gamma-glutamyltransferase predicts functional impairment in elderly adults after ischemic stroke", J Am Geriatr Soc, 61, pp.1040~1041 (2013)
- Yang W, "Gamma-glutamyl transferase predicts future stroke: a Korean nationwide study", Ann Neurol, 83, pp.375~386 (2018)
- Ruttmann E, "Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults", Circulation, 112, pp.2130~2137 (2005)
- Yu C, "Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke", Exp Neurol, 203, pp.116~122 (2007)
- Justicia C, "Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion", reperfusion of the middle cerebral artery in rats, 2003, pp.23, 1430~1440
- Kolaczkowska E, "Neutrophil recruitment and function in health and inflammation", Nat Rev Immunol, 13, pp.159~175 (2013)
- Pocock JM, "Neurotransmitter receptors on microglia", Trends Neurosci, 30, pp.527~535 (2007)
- Eltzschig HK, "Ischemia and reperfusion: from mechanism to translation", Nat Med, 17, pp.1391~1401 (2011)
- Urra X, "Harms and benefits of lymphocyte subpopulations in patients with acute stroke", Neuroscience, 158, pp.1174~1183 (2009)
- Liesz A, "Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke", Nat Med, 15, pp.192~199 (2009)
- Gold AB, "The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment", J Neuroinflammation, 8, pp.17~ (2011)
- Smith EA, "Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism", J Appl Bacteriol, 81, pp.288~302 (1996)
- Wang L, "Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A", Mol Biol Cell, 16, pp.2234~2247 (2005)
- Sun H, "Potential serum biomarkers and metabonomic profiling of serum in ischemic stroke patients using UPLC", Q-TOF MS, PLoS One, pp.2017, 12[DOI]
- Frisardi V, "Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer’s disease pathology", Prog Lipid Res, 50, pp.313~330 (2011)
- Mapstone M, "Plasma phospholipids identify antecedent memory impairment in older adults", Nat Med, 20, pp.415~418 (2014)
- Kim YJ, "Plasma phospholipid fatty acid composition in ischemic stroke: importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis", Atherosclerosis, 225, pp.418~424 (2012)
- Fretts AM, "Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study", Br J Nutr, 112, pp.1206~1213 (2014)
- Jové M, "Metabolomics predicts stroke recurrence after transient ischemic attack", Neurology, 84, pp.36~45 (2015)
- Ebert D, "Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy", J Neurosci, 23, pp.5928~5935 (2003)
- Schwartz MW, "Central nervous system control of food intake", Nature, 404, pp.661~671 (2000)
- Belgardt BF, "CNS leptin and insulin action in the control of energy homeostasis", Ann N Y Acad Sci, 1212, pp.97~113 (2010)
- Yoshida Y, "Bio-markers of lipid peroxidation in vivo: hydroxyoctadecadienoic acid and hydroxycholesterol", Biofactors, 27, pp.195~202 (2006)
- Capdevila JH, "Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension", Kidney Int, 72, pp.683~689 (2007)
- "Correction", Circulation, 131, pp.e535~ (2015)
- Nanetti L, "Sialic acid and sialidase activity in acute stroke", Dis Markers, 25, pp.167~173 (2008)
- Floegel A, "Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts", Eur J Epidemiol, 33, pp.55~66 (2018)
- Lee Y, "A metabolomic study on high-risk stroke patients determines low levels of serum lysine metabolites: a retrospective cohort study", Mol Biosyst, 13, pp.1109~1120 (2017)
- Romanos E, "Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke", J Cereb Blood Flow Metab, 27, pp.14~20 (2007)
- Zhu Z, "Combination of the immune modulator fingolimod with alteplase in acute ischemic stroke: a pilot trial", Circulation, 132, pp.1104~1112 (2015)
- Qureshi MI, "Lessons from metabonomics on the neurobiology of stroke", Neuroscientist, 23, pp.374~382 (2017)
