Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society
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초록
Despite the great socioeconomic burden of stroke, there have been few reports of stroke statistics in Korea. In this scenario, the Epidemiologic Research Council of the Korean Stroke Society launched the “Stroke Statistics in Korea” project, aimed at writing a contemporary, comprehensive, and representative report on stroke epidemiology in Korea. This report contains general statistics of stroke, prevalence of behavioral and vascular risk factors, stroke characteristics, pre-hospital system of care, hospital management, quality of stroke care, and outcomes. In this report, we analyzed the most up-to-date and nationally representative databases, rather than performing a systematic review of existing evidence. In summary, one in 40 adults are patients with stroke and 232 subjects per 100,000 experience a stroke event every year. Among the 100 patients with stroke in 2014, 76 had ischemic stroke, 15 had intracerebral hemorrhage, and nine had subarachnoid hemorrhage. Stroke mortality is gradually declining, but it remains as high as 30 deaths per 100,000 individuals, with regional disparities. As for stroke risk factors, the prevalence of smoking is decreasing in men but not in women, and the prevalence of alcohol drinking is increasing in women but not in men. Population-attributable risk factors vary with age. Smoking plays a role in young-aged individuals, hypertension and diabetes in middle-aged individuals, and atrial fibrillation in the elderly. About four out of 10 hospitalized patients with stroke are visiting an emergency room within 3 hours of symptom onset, and only half use an ambulance. Regarding acute management, the proportion of patients with ischemic stroke receiving intravenous thrombolysis and endovascular treatment was 10.7% and 3.6%, respectively. Decompressive surgery was performed in 1.4% of patients with ischemic stroke and in 28.1% of those with intracerebral hemorrhage. The cumulative incidence of bleeding and fracture at 1 year after stroke was 8.9% and 4.7%, respectively. The direct costs of stroke were about ₩1.68 trillion (KRW), of which ₩1.11 trillion were for ischemic stroke and ₩540 billion for hemorrhagic stroke. The great burden of stroke in Korea can be reduced through more concentrated efforts to control major attributable risk factors for age and sex, reorganize emergency medical service systems to give patients with stroke more opportunities for reperfusion therapy, disseminate stroke unit care, and reduce regional disparities. We hope that this report can contribute to achieving these tasks.
Abstract
Despite the great socioeconomic burden of stroke, there have been few reports of stroke statistics in Korea. In this scenario, the Epidemiologic Research Council of the Korean Stroke Society launched the “Stroke Statistics in Korea” project, aimed at writing a contemporary, comprehensive, and representative report on stroke epidemiology in Korea. This report contains general statistics of stroke, prevalence of behavioral and vascular risk factors, stroke characteristics, pre-hospital system of care, hospital management, quality of stroke care, and outcomes. In this report, we analyzed the most up-to-date and nationally representative databases, rather than performing a systematic review of existing evidence. In summary, one in 40 adults are patients with stroke and 232 subjects per 100,000 experience a stroke event every year. Among the 100 patients with stroke in 2014, 76 had ischemic stroke, 15 had intracerebral hemorrhage, and nine had subarachnoid hemorrhage. Stroke mortality is gradually declining, but it remains as high as 30 deaths per 100,000 individuals, with regional disparities. As for stroke risk factors, the prevalence of smoking is decreasing in men but not in women, and the prevalence of alcohol drinking is increasing in women but not in men. Population-attributable risk factors vary with age. Smoking plays a role in young-aged individuals, hypertension and diabetes in middle-aged individuals, and atrial fibrillation in the elderly. About four out of 10 hospitalized patients with stroke are visiting an emergency room within 3 hours of symptom onset, and only half use an ambulance. Regarding acute management, the proportion of patients with ischemic stroke receiving intravenous thrombolysis and endovascular treatment was 10.7% and 3.6%, respectively. Decompressive surgery was performed in 1.4% of patients with ischemic stroke and in 28.1% of those with intracerebral hemorrhage. The cumulative incidence of bleeding and fracture at 1 year after stroke was 8.9% and 4.7%, respectively. The direct costs of stroke were about ₩1.68 trillion (KRW), of which ₩1.11 trillion were for ischemic stroke and ₩540 billion for hemorrhagic stroke. The great burden of stroke in Korea can be reduced through more concentrated efforts to control major attributable risk factors for age and sex, reorganize emergency medical service systems to give patients with stroke more opportunities for reperfusion therapy, disseminate stroke unit care, and reduce regional disparities. We hope that this report can contribute to achieving these tasks.
참고문헌 (61)
- Lozano R, "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010", Lancet, 380, pp.2095~2128 (2012)
- Murray CJ, "Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010", Lancet, 380, pp.2197~2223 (2012)
- Annual Report on the Causes of Death Statistics, "Korean Statistical Information Service", Statistics Korea, ~ (2016)
- Feigin VL, "Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review", Lancet Neurol, 8, pp.355~369 (2009)
- Keun-Sik Hong, "Stroke Statistics in Korea: Part I. Epidemiology and Risk Factors: A Report from the Korean Stroke Society and Clinical Research Center for Stroke", 대한뇌졸중영문학회지, 15(1), pp.2~20 (2013), 대한뇌졸중학회[DOI]
- 홍근식, "Stroke Statistics in Korea: Part II Stroke Awareness and Acute Stroke Care, A Report from the Korean Stroke Society and Clinical Research Center For Stroke", 대한뇌졸중영문학회지, 15(2), pp.67~77 (2013), 대한뇌졸중학회[DOI]
- 김범준, "Case Characteristics, Hyperacute Treatment, and Outcome Information from the Clinical Research Center for Stroke-Fifth Division Registry in South Korea", 대한뇌졸중영문학회지, 17(1), pp.38~53 (2015), 대한뇌졸중학회
- Kim BJ, "Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry", Int J Stroke, 9, pp.514~518 (2014)
- Stroke statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society, "Kim JY", Korean Stroke Society, ~ (2018)
- Kweon S, "Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- Lee J, "Cohort profile: the National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea", Int J Epidemiol, 46, pp.e15~ (2017)
- "Construction of national surveillance system for cardiovascular & cerebrovascular diseases" (2006)[URL]
- "Population projection and summary indicator for Korea (population items)" (2018)[URL]
- Feigin VL, "Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010", Lancet, 383, pp.245~254 (2014)
- "Estimating the incidence of acute myocardial infarction and stroke based on the National Health Insurance claims data in Korea" (2016)[URL]
- Narayanaswamy Venketasubramanian, "Stroke Epidemiology in South, East, and South-East Asia: A Review", 대한뇌졸중영문학회지, 19(3), pp.286~294 (2017), 대한뇌졸중학회
- Benjamin EJ, "Heart disease and stroke statistics-2018 update: a report from the American Heart Association", Circulation, 137, pp.e67~e492 (2018)
- Age Standardization of Rates: A New WHO Standard, "Ahmad OB", World Health Organization, ~ (2013)
- Xu J, "Mortality in the United States, 2015", NCHS Data Brief, 267, pp.1~8 (2016)
- Howard VJ, "The reasons for geographic and racial differences in stroke study: objectives and design", Neuroepidemiology, 25, pp.135~143 (2005)
- Karp DN, "Reassessing the stroke belt: using small area spatial statistics to identify clusters of high stroke mortality in the United States", Stroke, 47, pp.1939~1942 (2016)
- Lanska DJ, "Geographic distribution of stroke mortality in the United States: 1939-1941 to 1979-1981", Neurology, 43, pp.1839~1851 (1993)
- Howard G, "Evaluation of social status as a contributing factor to the stroke belt region of the United States", Stroke, 28, pp.936~940 (1997)
- Lackland DT, "Factors influencing the decline in stroke mortality: a statement from the American Heart Association", American Stroke Association, 2014, pp.45, 315~353
- "Global Status Report on Alcohol and Health" (2011)[URL]
- Ogden CL, "Prevalence of overweight and obesity in the United States, 1999-2004", JAMA, 295, pp.1549~1555 (2006)
- Korean Society Hypertension, "Korea hypertension fact sheet 2018", Clin Hypertens, 24, pp.13~ (2018)
- 김대중, "The Epidemiology of Diabetes in Korea", Diabetes and Metabolism Journal, 35(4), pp.303~308 (2011), 대한당뇨병학회
- Colilla S, "Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population", Am J Cardiol, 112, pp.1142~1147 (2013)
- Krijthe BP, "Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060", Eur Heart J, 34, pp.2746~2751 (2013)
- 박태환, "Identifying Target Risk Factors Using Population Attributable Risks of Ischemic Stroke by Age and Sex", 대한뇌졸중영문학회지, 17(3), pp.302~311 (2015), 대한뇌졸중학회
- Wolf PA, "Atrial fibrillation as an independent risk factor for stroke: the Framingham Study", Stroke, 22, pp.983~988 (1991)
- Friberg L, "Assessment of female sex as a risk factor in atrial fibrillation in Sweden: nationwide retrospective cohort study", BMJ, 344, pp.e3522~ (2012)
- Kleindorfer DO, "Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati", Northern Kentucky Stroke Study, 2010, pp.41, 1326~1331
- Tsai CF, "Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review", Neurology, 81, pp.264~272 (2013)
- 고영채, "MRI-based Algorithm for Acute Ischemic Stroke Subtype Classification", 대한뇌졸중영문학회지, 16(3), pp.161~172 (2014), 대한뇌졸중학회[DOI]
- Jung KH, "Secular trends in ischemic stroke characteristics in a rapidly developed country: results from the Korean Stroke Registry Study (secular trends in Korean stroke)", Circ Cardiovasc Qual Outcomes, 5, pp.327~334 (2012)
- Bogiatzi C, "Secular trends in ischemic stroke subtypes and stroke risk factors", Stroke, 45, pp.3208~3213 (2014)
- Reeves M, "Distribution of National Institutes of Health stroke scale in the Cincinnati", Northern Kentucky Stroke Study, 2013, pp.44, 3211~3213
- Zahuranec DB, "Intracerebral hemorrhage mortality is not changing despite declining incidence", Neurology, 82, pp.2180~2186 (2014)
- Fonarow GC, "Characteristics, performance measures, and inhospital outcomes of the first one million stroke and transient ischemic attack admissions in get with the guidelinesstroke", Circ Cardiovasc Qual Outcomes, 3, pp.291~302 (2010)
- Price CI, "An observational study of patient characteristics associated with the mode of admission to acute stroke services in North East, England", PLoS One, 8, pp.e76997~ (2013)
- Inatomi Y, "Prehospital delay in the use of intravenous rt-PA for acute ischemic stroke in Japan", J Neurol Sci, 270, pp.127~132 (2008)
- Mochari-Greenberger H, "Racial", ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the national Get With The Guidelines-Stroke registry, 2015, pp.4, e002099~
- Abdullah AR, "Advance hospital notification by EMS in acute stroke is associated with shorter door-to-computed tomography time and increased likelihood of administration of tissueplasminogen activator", Prehosp Emerg Care, 12, pp.426~431 (2008)
- Derex L, "Factors influencing early admission in a French stroke unit", Stroke, 33, pp.153~159 (2002)
- Fassbender K, "Streamlining of prehospital stroke management: the golden hour", Lancet Neurol, 12, pp.585~596 (2013)
- Schwamm LH, "Temporal trends in patient characteristics and treatment with intravenous thrombolysis among acute ischemic stroke patients at Get With The Guidelines-Stroke hospitals", Circ Cardiovasc Qual Outcomes, 6, pp.543~549 (2013)
- Scherf S, "Increase in national intravenous thrombolysis rates for ischaemic stroke between 2005 and 2012: is bigger better?", BMC Neurol, 16, pp.53~ (2016)
- The burden of stroke in Europe report, "King’s College of London for the Stroke Alliance for Europe", SAFE, ~ (2018)
- Smith EE, "Increase in endovascular therapy in Get With The Guidelines: stroke after the publication of pivotal trials", Circulation, 136, pp.2303~2310 (2017)
- The Quality of Stroke Care in Canada, "Canadian Stroke Network", Canadian Stroke Network, ~ (2011)
- National Stroke Audit: Acute Services Report 2015, "National Stroke Foundation", National Stroke Foundation, ~ (2015)
- Hsieh FI, "Get With the Guidelines-stroke performance indicators: surveillance of stroke care in the Taiwan Stroke Registry: Get With the Guidelines-stroke in Taiwan", Circulation, 122, pp.1116~1123 (2010)
- Bushnell CD, "Secondary preventive medication persistence and adherence 1 year after stroke", Neurology, 77, pp.1182~1190 (2011)
- Kim J, "Establishment of government-initiated comprehensive stroke centers for acute ischemic stroke management in South Korea", Stroke, 45, pp.2391~2396 (2014)
- "OECD Health Statistics 2018" (2018)[URL]
- Andersen KK, "Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke", Stroke, 42, pp.2806~2812 (2011)
- Bray BD, "Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England", Lancet Public Health, 3, pp.e185~e193 (2018)
- 윤석준, "Measuring the Burden of Disease in Korea", Journal of Korean Medical Science, 22(3), pp.518~523 (2007), 대한의학회
- Yoon J, "Disability-adjusted life years for 313 diseases and injuries: the 2012 Korean Burden of Disease Study", J Korean Med Sci, 31(Suppl 2), pp.S146~S157 (2016)
