Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression
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초록
Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program,and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsyspecimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic activegastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and applegreenbirefringence was shown using polarized light microscopy. Immunohistochemical staining revealed the presence of kappaand lambda chain-positive plasma cells. There was no evidence of underlying plasma cell dyscrasia or amyloid deposition in othersegments of the gastrointestinal tract. Echocardiography and computed tomography of the chest, abdomen, and pelvis did not showany significant findings. Thus, the patient was diagnosed with localized gastric amyloidosis with kappa and lambda light chain coexpression.
Abstract
Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program,and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsyspecimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic activegastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and applegreenbirefringence was shown using polarized light microscopy. Immunohistochemical staining revealed the presence of kappaand lambda chain-positive plasma cells. There was no evidence of underlying plasma cell dyscrasia or amyloid deposition in othersegments of the gastrointestinal tract. Echocardiography and computed tomography of the chest, abdomen, and pelvis did not showany significant findings. Thus, the patient was diagnosed with localized gastric amyloidosis with kappa and lambda light chain coexpression.
참고문헌 (17)
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