급성 백혈병 환자에서 Vincristine에 의해 유발된 다발성 신경병증
A case of vincristine-induced polyneuropathy in an patient with acute leukemia
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본 증례의 경우처럼 급성 림프구성 백혈병 환자에서 항암화학요법 후 발생하는 다발성 뇌신경 및 말초성 신경병증은 유사한 임상증상으로 나타나는 질환들과의 감별진단이 필요 하겠고, 중추신경계 증상이 같이 동반되어 있더라도 vincristine에 의한 신경독성의 가능성을 고려해야 하겠다.
Abstract
When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We describe a 16-year-old girl with acute lymphoblastic leukemia that appeared to be complicated by vincristine-induced peripheral and cranial polyneuropathy after induction chemotherapy. She presented with right ptosis six weeks after the first dose of vincristine, and her neurological symptoms progressed to peripheral polyneuropathy. She recovered from these neurological symptoms over the next three months. Leukemic involvement of the nervous system and other neurological disorders could be excluded as potential causes of the neurological symptoms. This report shows that vincristine-induced neurotoxicity should be considered as a cause of cranial neuropathy that develops during the treatment of acute lymphoblastic leukemia.
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