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진행성 비소세포폐암의 예후에 있어 FDG-PET의 중요성에 대한 연구

The prognostic significance of FDG-PET in advanced non-small cell lung cancer

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초록

Background/Aims: Lung cancer is the leading cause of cancer-related death in Korea. Non-small cell lung cancer (NSCLC) comprises 80~85% of lung cancer. Positron emission tomography with [18F]fluorodeoxyglucose (FDG-PET) shows various levels of FDG uptake for patients with NSCLC. This study determined whether the standardized uptake value (SUV) of FDG uptake by PET is a prognostic factor for advanced NSCLC. Methods: FDG-PET was performed in 59 patients with stage IIIb and IV NSCLC. The SUV was calculated for each patient. Overall survival (OS) and time to progression were calculated using the Kaplan-Meier method and evaluated with the log-rank test. The prognostic significance was assessed using univariate and multivariate analyses. Results: A cutoff of 7 for the SUV gave the best criminative value. In the univariate analysis, performance status (p=0.02) and SUV (p=0.03) were significant predictors of OS. The patients with low SUVs (≤7) had significantly better times to progression than those with high SUVs (>7, p=0.04). A multivariate Cox analysis identified performance status and the SUV as important for the prognosis. Conclusions: These results suggest that SUV is a significant prognostic factor in patients with advanced non-small cell lung cancer.

Abstract

Background/Aims: Lung cancer is the leading cause of cancer-related death in Korea. Non-small cell lung cancer (NSCLC) comprises 80~85% of lung cancer. Positron emission tomography with [18F]fluorodeoxyglucose (FDG-PET) shows various levels of FDG uptake for patients with NSCLC. This study determined whether the standardized uptake value (SUV) of FDG uptake by PET is a prognostic factor for advanced NSCLC. Methods: FDG-PET was performed in 59 patients with stage IIIb and IV NSCLC. The SUV was calculated for each patient. Overall survival (OS) and time to progression were calculated using the Kaplan-Meier method and evaluated with the log-rank test. The prognostic significance was assessed using univariate and multivariate analyses. Results: A cutoff of 7 for the SUV gave the best criminative value. In the univariate analysis, performance status (p=0.02) and SUV (p=0.03) were significant predictors of OS. The patients with low SUVs (≤7) had significantly better times to progression than those with high SUVs (>7, p=0.04). A multivariate Cox analysis identified performance status and the SUV as important for the prognosis. Conclusions: These results suggest that SUV is a significant prognostic factor in patients with advanced non-small cell lung cancer.

참고문헌 (21)

  1. 2002 Annual report of the Korea Central Cancer registry, "Ministry of Health and Welfare", ~ (2003)
  2. 2004 Annual report on the cause of death statistics, "Korea National Statistic Office", ~ (2005)
  3. Devita VT, "Cancer: principles and practice of oncology. 7th ed", pp.793~ (2005), Lippincott Williams & Wilkins
  4. Schiller JH, "Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer", N Engl J Med, 346, pp.92~98 (2002)
  5. Hoang T, "Clinical model to predictsurvival in chemonaive patients with advanced non-small-cell-lung cancer treated with third-generation chemotherapy regimen based on eastern cooperative oncology group data", J Clin Oncol, 23, pp.175~183 (2005)
  6. Paesmans M, "Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European Lung Cancer Working Party", J Clin Oncol, 13, pp.1221~1230 (1995)
  7. Vansteenkiste JF, "Prognostic importance of the standardized uptake value on 18F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: an analysis of 125 cases. Leuven Lung Cancer Group", J Clin Oncol, 17, pp.3201~3206 (1999)
  8. Kostakoglu L, "18F-FDG PET evaluation of the response to therapy for lymphoma and for breast, lung, and colorectal carcinoma", J Nucl Med, 44, pp.224~239 (2003)
  9. fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy, "J Clin Oncol", 2002, 1398~1404
  10. MacManus MP, "High rate of detection of unsuspected distant metastases by PET in apparent stage III non-small-cell lung cancer: implications for radical radiation therapy", Int J Radiat Oncol Biol Phys, 50, pp.287~293 (2001)
  11. MacManus MP, "F-18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with non small cell lung carcinoma: powerful correlation with survival and high impact on treatment", Cancer, 92, pp.886~895 (2001)
  12. Ryu JS, "FDGPET in staging and restaging non-small cell lung cancer after neoadjuvant chemoradiotherapy: correlation with histopathology", Lung Cancer, 35, pp.179~187 (2002)
  13. fluoro-2-deoxy-D-glucose positron emission tomography in the selection of patients with stage IIIA-N2 non-small cell lung cancer for combined modality treatment, "Lung Cancer", 2003, 151~157
  14. MacManus MP, "Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with nonsmall-cell lung cancer", J Clin Oncol, 21, pp.1285~1292 (2003)
  15. Duhaylongsod FG, "Lung tumor growth correlates with glucose metabolism measured by fluoride-18-fluorodeoxyglucose positron emission tomography", Ann Thorac Surg, 60, pp.1348~1352 (1995)
  16. Younes M, "Overexpression of Glut1 and Glut3 in stage I non small cell lung carcinoma is associated with poor survival", Cancer, 80, pp.1046~1051 (1997)
  17. Gatenby RA, "The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models", Cancer Res, 63, pp.3847~3854 (2003)
  18. Higashi K, "18F-FDG uptake as a biologic prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer", J Nucl Med, 43, pp.39~45 (2002)
  19. fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer, "J Clin Oncol", 2005, 1136~1143
  20. fluorodeoxyglucose uptake by positron emission tomography, "Clin Cancer Res", 2000, 3837~3844
  21. Hoang JK, "Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography imaging in patients with advanced-stage non-small-cell lung carcinoma", J Clin Oncol, 26, pp.1459~1464 (2008)

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