새로운 항생제의 개발
New antimicrobials on the horizon
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Recently, infections caused by antibiotic-resistant bacteria continue to climb in the community and the hospital around the world. Our current antimicrobial agents are gradually becoming ineffective and a new pipeline of powerful compounds is needed urgently. A number of new antimicrobial compounds are in development, including novel glycopeptides (dalbavancin, telavancin, and oritavancin), daptomycin, tigecycline, ceftobiprole, iclaprim, and doripenem. The article will provide an update on the newly marketed and potentially effective antibacterial agents in the late-stage development pipeline.
Abstract
Recently, infections caused by antibiotic-resistant bacteria continue to climb in the community and the hospital around the world. Our current antimicrobial agents are gradually becoming ineffective and a new pipeline of powerful compounds is needed urgently. A number of new antimicrobial compounds are in development, including novel glycopeptides (dalbavancin, telavancin, and oritavancin), daptomycin, tigecycline, ceftobiprole, iclaprim, and doripenem. The article will provide an update on the newly marketed and potentially effective antibacterial agents in the late-stage development pipeline.
참고문헌 (65)
- Rice LB, "Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE", J Infect Dis, 197, pp.1079~1081 (2008)
- "Infectious Diseases Society of America. The epidemic of antibiotic resistant infections: a call to action for the medical community from the Infectious Diseases Society of America", Clin Infect Dis, 46, pp.155~164 (2008)
- Sakoulas G, "Adaptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy", Clin Infect Dis, 42, pp.S40~S50 (2006)
- Robert J, "Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20 year study in a large French teaching hospital, 1983-2002", J Antimicrob Chemother, 57, pp.506~510 (2006)
- Bradley JS, "Anti-infective research and development-problems, challenges, and solutions", Lancet Infect Dis, 7, pp.68~78 (2007)
- 이경원, "High Prevalence of Ceftazidime-Resistant Klebsiella pneumoniae and Increase of Imipenem-Resistant", Yonsei Medical Journal, 47(5), pp.634~645 (2006), 연세대학교의과대학
- Micek ST, "Alternatives to vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections", Clin Infect Dis, 15, pp.S184~S190 (2007)
- Boucher HW, "Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America", Clin Infect Dis, 48, pp.1~12 (2009)
- Enoch DA, "Daptomycin", J Infection, 55, pp.205~213 (2007)
- Arbeit RD, "The safety and efficacy of daptomycin for the treatment of complicated kin and skin-structure infections", Clin Infect Dis, 38, pp.1673~1681 (2004)
- Fowler Jr VG, "Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus", N Engl J Med, 344, pp.653~665 (2006)
- Rybak MJ, "The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria", Clin Microbiol Infect, 12, pp.24~32 (2006)
- Sakoulas G, "Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin", Antimicrob Agents Chemother, 50, pp.1581~1585 (2006)
- Arias CA, "Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster", Clin Infect Dis, 45, pp.1343~1346 (2007)
- Sakoulas G, "Perspectives on daptomycin resistance, with emphasis on resistance in Staphylococcus aureus", Clin Infect Dis, 45, pp.601~608 (2007)
- Pankey GA, "Tigecycline", J Antimicrob Chemother, 56, pp.470~480 (2005)
- Stein GE, "Tigecycline : A Critical Analysis", Clin Infect Dis, 43, pp.518~524 (2006)
- No authors listed, "Ceftobiprole Medocaril: BAL5788, JNJ 30982081, JNJ30982081, RO 65-5788, RO 655788", Drugs R D, 7, pp.305~311 (2006)
- Noel GJ, "A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections", Clin Infect Dis, 46, pp.647~655 (2008)
- Denis O, "In vitro activities of ceftobiprole, Tigecycline, Daptomycin and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals", Antimicrob Agents Chemother, 50, pp.2680~2685 (2006)
- Chambers HF, "Ceftobiprole: in vivo profile of a bactericidal cephalosporin", Clin Microbiol Infect, 12, pp.17~22 (2006)
- Murthy B, "Pharmacokinetics and pharmacodynamics of ceftobiprole, an anti-MRSA cephalosporin with broad-spectrum activity", Clin Pharmacokinet, 47, pp.21~33 (2008)
- Zhanel GG, "Ceftaroline: A Novel Broad-Spectrum Cephalosporin with Activity against Meticillin-Resistant Staphylococcus aureus", Drugs, 69, pp.809~831 (2009)
- Sader HS, "Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains", Antimicrob Agents Chemother, 49, pp.3501~3512 (2005)
- Jacqueline C, "In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model", Antimicrob Agents Chemother, 51, pp.3397~3400 (2007)
- Talbot GH, "Phase 2 study of ceftaroline versus standard therapy in treatment of complicated skin and skin structure infections", Antimicrob Agents Chemother, 51, pp.3612~3616 (2007)
- Chen AY, "Dalbavancin: a novel antimicrobial", Int J Clin Pract, 61, pp.853~863 (2007)
- Decousser JW, "Dalbavancin, a long-acting lipoglycopeptide for the treatment of multidrug-resistant Gram-positive bacteria", Expert Rev Anti Infect Ther, 5, pp.557~571 (2007)
- Kim A, "Review of dalbavancin, a novel semisynthetic lipoglycopeptide", Expert Opin Investig Drugs, 16, pp.717~733 (2007)
- Scheinfeld N, "Dalbavancin: a review", Drugs Today, 43, pp.305~316 (2007)
- Cavaleri M, "Pharmacokinetics and excretion of dalbavancin in the rat", J Antimicrob Chemother, 55, pp.ii31~ii35 (2005)
- Leighton A, "Tolerability, pharmacokinetics, and serum bactericidal activity of intravenous dalbavancin in healthy volunteers", Antimicrob Agents Chemother, 48, pp.940~945 (2004)
- Jauregui LE, "Randomized, double-blind comparison of onceweekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections", Clin Infect Dis, 41, pp.1407~1415 (2005)
- Seltzer E, "l. Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections", Clin Infect Dis, 37, pp.1298~1303 (2003)
- Goldstein BP, "Microbiologic characterization of isolates from a dalbavancin clinical trial for catheter-related bloodstream infections", Diagn Microbiol Infect Dis, 54, pp.83~87 (2006)
- Ward KE, "Oritavancin - an investigational glycopeptide antibiotic", Expert Opin Investig Drugs, 15, pp.417~429 (2006)
- Mercier RC, "Oritavancin: a new avenue for resistant Gram-positive bacteria", Expert Rev Anti Infect Ther, 3, pp.325~332 (2005)
- Biavasco F, "In vitro antibacterial activity of LY333328, a new semisynthetic glycopeptide", Antimicrob Agents Chemother, 41, pp.2165~2172 (1997)
- Van Bambeke F, "Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages", Antimicrob Agents Chemother, 48, pp.2853~2860 (2004)
- Fetterly GJ, "Pharmacokinetics of oritavancin in plasma and skin blister fluid following administration of a 200-milligram dose for 3 days or a single 800-milligram dose", Antimicrob Agents Chemother, 49, pp.148~152 (2005)
- Anderson DL, "Oritavancin for skin infections", Drugs Today, 44, pp.563~575 (2008)
- Kanafani ZA, "Telavancin: a new lipoglycopeptide with multiple mechanisms of action", Expert Rev Anti Infect Ther, 4, pp.743~749 (2006)
- Laohavaleeson S, "Telavancin: a novel lipoglycopeptide for serious gram-positive infections", Expert Opin Investig Drugs, 16, pp.347~357 (2007)
- Stucki A, "Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters", Antimicrob Agents Chemother, 50, pp.770~773 (2006)
- Shaw JP, "Pharmacokinetics, serum inhibitory and bactericidal activity, and safety of telavancin in healthy subjects", Antimicrob Agents Chemother, 49, pp.195~201 (2005)
- Sun HK, "Tissue penetration of telavancin after intravenous administration in healthy subjects", Antimicrob Agents Chemother, 50, pp.788~790 (2006)
- Pace JL, "In vitro activity of TD-6424 against Staphylococcus aureus", Antimicrob Agents Chemother, 47, pp.3602~3604 (2003)
- Stryjewski ME, "Assessment of Telavancin in Complicated Skin and Skin-Structure Infections Study. Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms", Clin Infect Dis, 46, pp.1683~1693 (2008)
- Fung-Tomc JC, "Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756", Antimicrob Agents Chemother, 44, pp.3351~3356 (2000)
- Jones RN, "Activity of garenoxacin, an investigational des-F(6)-quinolone, tested against pathogens from community-acquired respiratory tract infections, including those with elevated or resistant-level fluoroquinolone MIC values", Diagn Microbiol Infect Dis, 58, pp.9~17 (2007)
- Gajjar DA, "Multiple-dose safety and pharmacokinetics of oral garenoxacin in healthy subjects", Antimicrob Agents Chemother, 47, pp.2256~2263 (2003)
- Van Wart S, "Population pharmacokinetics and pharmacodynamics of garenoxacin in patients with community-acquired respiratory tract infections", Antimicrob Agents Chemother, 48, pp.4766~4777 (2004)
- Krishna G, "Effect of an aluminum- and magnesium-containing antacid on the bioavailability of garenoxacin in healthy volunteers", Pharmacotherapy, 27, pp.963~969 (2007)
- Krishna G, "The effect of omeprazole on the bioavailability and safety of garenoxacin in healthy volunteers", J Clin Pharmacol, 47, pp.628~632 (2007)
- Takagi H, "Clinical studies of garenoxacin", Int J Antimicrob Agents, 32, pp.468~474 (2008)
- Hawser S, "Dihydrofolate reductase inhibitors as antibacterial agents", Biochem Pharmacol, 71, pp.941~948 (2006)
- Schneider P, "Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria", Bioorg Med Chem Lett, 13, pp.4217~4221 (2003)
- Andrews J, "Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg", kg of iclaprim (AR-100) in healthy men, 2007, pp.60, 677~680
- Laue H, "In vitro activity of the novel diaminopyrimidine, iclaprim, in combination with folate inhibitors and other antimicrobials with different mechanisms of action", J Antimicrob Chemother, 60, pp.1391~1394 (2007)
- French GL, "What’s new and not so new on the antimicrobial horizon?", Clin Microbiol Infect, 14, pp.S19~S29 (2008)
- "Doripenem: S 4661", Drugs R D, 4, pp.363~365 (2003)
- Lister PD, "Carbapenems in the USA: focus on doripenem", Expert Rev Anti Infect Ther, 5, pp.793~809 (2007)
- Jones RN, "Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various beta-lactamase resistance mechanisms", Diagn Microbiol Infect Dis, 52, pp.71~74 (2005)
- Fritsche TR, "Antimicrobial activity of doripenem (S-4661): a global surveillance report (2003)", Clin Microbiol Infect, 11, pp.974~984 (2005)
- Zhanel GG, "Comparative review of the carbapenems", Drugs, 67, pp.1027~1052 (2007)
