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Stroke Update: 뇌졸중 예방을 위한 적절한 혈압 조절

Stroke Update: Optimal Blood Pressure Management for Stroke Prevention

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초록

Hypertension is the most important risk factor for stroke. Blood pressure control results in signifi cant reduction in most cardiovascular events, especially stroke. Several recent studies investigated the effects of tight blood pressure control on the development of cardiovascular events including stroke. On the other hand, besides mean blood pressure, which is the conventional target for hypertension management, the importance of blood pressure variability has been issued recently. Optimal target of blood pressure level and blood pressure variability for stroke prevention will be discussed. (Korean J Stroke 2011;13:63-65)

Abstract

Hypertension is the most important risk factor for stroke. Blood pressure control results in signifi cant reduction in most cardiovascular events, especially stroke. Several recent studies investigated the effects of tight blood pressure control on the development of cardiovascular events including stroke. On the other hand, besides mean blood pressure, which is the conventional target for hypertension management, the importance of blood pressure variability has been issued recently. Optimal target of blood pressure level and blood pressure variability for stroke prevention will be discussed. (Korean J Stroke 2011;13:63-65)

참고문헌 (14)

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  2. The ACCORD Study Group, "Effects of intensive bloodpressure control in type 2 diabetes mellitus", N Engl J Med, 362, pp.1575~1585 (2010)
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  7. Chimowitz MI, "Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosi s", N Engl J Med, 352, pp.1305~1316 (2005)
  8. Chaturvedi S, "Risk factor status and vascular events in patients with symptomatic intracranial stenosis", Neurology, 69, pp.2063~2068 (2007)
  9. Turan TN, "Relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis", Circulation, 115, pp.2969~2975 (2007)
  10. Verdecchia P, "Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial", Lancet, 374, pp.525~533 (2009)
  11. Sleight P, "Prognostic value of blood pressure in patients with high vascular risk in the ongoing telmisartan alone and in combination with ramipril global endpoint trial study", J Hypertens, 27, pp.1360~1369 (2009)
  12. Arima H, "Lower target blood pressures are safe and effective for the prevention of recurrent stroke: the PROGRESS trial", Journal of Hypertension, 24, pp.1201~1208 (2006)
  13. "Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendrofl umethiazide as required, in the Anglo-Scandinavian Cardiac Outco mes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial", Lancet, 366, pp.895~906 (2005)
  14. Sandset EC, "The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial", Lancet, 377, pp.741~750 (2011)

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