A Case of Eosinophilic Esophagitis Associated with Herpes Esophagitis in a Pediatric Patient
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Eosinophilic esophagitis is a rare disease in Asian countries, but its incidence is growing rapidly in Western countries. The mainpathophysiology of eosinophilic esophagitis is esophageal epithelial barrier dysfunction; disruption of the esophageal epithelial barriereasily induces antigen sensitization to foods and aeroallergens, which leads to subsequent esophageal inflammation as a result ofeosinophil recruitment. Here we report a case of an 11-year-old Korean boy who suffered from fever, odynophagia, dysphagia, and chestpain. His upper endoscopic findings showed longitudinal ulcers with a volcano-like appearance at the distal esophagus. Polymerasechain reaction test results and biopsy specimens were positive for herpes simplex virus type 1. He was treated with acyclovir and aproton pump inhibitor, but his follow-up endoscopy showed typical patterns of eosinophilic esophagitis, and the biopsy specimens werecompatible with the diagnostic criteria for eosinophilic esophagitis. Therefore, we report a very rare case of eosinophilic esophagitisafter herpes esophagitis in a Korean child with normal immunity.
Abstract
Eosinophilic esophagitis is a rare disease in Asian countries, but its incidence is growing rapidly in Western countries. The mainpathophysiology of eosinophilic esophagitis is esophageal epithelial barrier dysfunction; disruption of the esophageal epithelial barriereasily induces antigen sensitization to foods and aeroallergens, which leads to subsequent esophageal inflammation as a result ofeosinophil recruitment. Here we report a case of an 11-year-old Korean boy who suffered from fever, odynophagia, dysphagia, and chestpain. His upper endoscopic findings showed longitudinal ulcers with a volcano-like appearance at the distal esophagus. Polymerasechain reaction test results and biopsy specimens were positive for herpes simplex virus type 1. He was treated with acyclovir and aproton pump inhibitor, but his follow-up endoscopy showed typical patterns of eosinophilic esophagitis, and the biopsy specimens werecompatible with the diagnostic criteria for eosinophilic esophagitis. Therefore, we report a very rare case of eosinophilic esophagitisafter herpes esophagitis in a Korean child with normal immunity.
참고문헌 (18)
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